Eicosanoid metabolism via Cyclo Oxygenases (COX) (Homo sapiens)

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3412412111PLA2G5PTGISPPARDGlycerophospholipids11Arachidonic acid2, 4PLA2G6PLA2G4APLA2G4BPTGS1PTGS2PGG2PGH2PGE211PTGESPGF2a1PGD2PGJ22delta-12-PGJ215-deoxy-delta-12-PGD222PTGDS111-HETE4PGI216-keto-PGF1alpha6-keto-PGE1PGA2PGB215-deoxy-PGA2AKR1B1Dinor-PGE2Tetranor-PGE2Dinor-PGF2aTetranor-PGF2aDinor-PGD2Tetranor-PGD220-hydroxy-PGE220-hydroxy-PGF2a420-hydroxy-PGD215-deoxy-delta-12-PGJ2TXA21TXB211-dehydro-TXB212S-HHTrETBXAS12Txdh15-keto-PGE215-keto-PGF2a115-keto-PGD213,14-dihydro-15-keto-PGE213,14-dihydro-15-keto-PGF2a13,14-dihydro-15-keto-PGD2PTGR1PTGR2HPGDCYP4A11CYP4A22CYP4A22CYP4F12CYP4F2HPGDACOX11ACOX2ACOX3ACAA1EHHADHPTGIR11PPAR gamma1PRXL2B1PTGFR1111PPAR gamma1PTGDR11PTGDR2111TBXA2R11PTGS1415(S)-HETE15(R)-HETE4AAS444PTGS14AAS444


Description

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [2]).

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[3], lipooxygenases(LOX)[4], or cytochrome P450 monooxygenases (CYP)[5]. This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes.

Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4347_106328.gpml] with a 87.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC
  2. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC
  3. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC
  4. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoicacids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
107596view15:13, 23 October 2019DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-HETEMetaboliteLMFA03060085 (LIPID MAPS)
11-dehydro-TXB2MetaboliteLMFA03030004 (LIPID MAPS)
12S-HHTrEMetaboliteLMFA03050002 (LIPID MAPS)
13,14-dihydro- 15-keto-PGD2MetaboliteLMFA03010022 (LIPID MAPS)
13,14-dihydro- 15-keto-PGE2MetaboliteLMFA03010031 (LIPID MAPS)
13,14-dihydro- 15-keto-PGF2aMetaboliteLMFA03010027 (LIPID MAPS)
15(R)-HETEMetaboliteLMFA03060030 (LIPID MAPS)
15(S)-HETEMetaboliteLMFA03060001 (LIPID MAPS)
15-deoxy-PGA2MetaboliteLMFA03010172 (LIPID MAPS)
15-deoxy-delta-12-PGD2MetaboliteLMFA03010021 (LIPID MAPS)
15-deoxy-delta-12-PGJ2MetaboliteLMFA03010021 (LIPID MAPS)
15-keto-PGD2MetaboliteLMFA03010022 (LIPID MAPS)
15-keto-PGE2MetaboliteLMFA03010030 (LIPID MAPS)
15-keto-PGF2aMetaboliteLMFA03010026 (LIPID MAPS)
20-hydroxy-PGD2MetaboliteLMFA03010216 (LIPID MAPS)
20-hydroxy-PGE2MetaboliteLMFA03010014 (LIPID MAPS)
20-hydroxy-PGF2aMetaboliteLMFA03010029 (LIPID MAPS)
6-keto-PGE1MetaboliteLMFA03010012 (LIPID MAPS)
6-keto-PGF1alphaMetaboliteLMFA03010001 (LIPID MAPS)
AASProtein
ACAA1ProteinENSG00000060971 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
ACOX1ProteinENSG00000161533 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX2ProteinENSG00000168306 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
ACOX3ProteinENSG00000087008 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
AKR1B1ProteinENSG00000085662 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11677
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
CYP4A11ProteinENSG00000187048 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
CYP4A22ProteinENSG00000162365 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12ProteinENSG00000186204 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2ProteinENSG00000186115 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
Dinor-PGD2MetaboliteLMFA03010214 (LIPID MAPS)
Dinor-PGE2MetaboliteLMFA03010210 (LIPID MAPS)
Dinor-PGF2aMetaboliteLMFA03010212 (LIPID MAPS)
EHHADHProteinENSG00000113790 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
GlycerophospholipidsCHEBI:37739 (ChEBI)
HPGDGeneProductENSG00000164120 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15446
PGA2MetaboliteLMFA03010035 (LIPID MAPS)
PGB2MetaboliteLMFA03010018 (LIPID MAPS)
PGD2MetaboliteLMFA03010004 (LIPID MAPS)
PGE2MetaboliteLMFA03010003 (LIPID MAPS)
PGF2aMetaboliteLMFA03010002 (LIPID MAPS)
PGG2MetaboliteLMFA03010009 (LIPID MAPS)
PGH2MetaboliteLMFA03010010 (LIPID MAPS)
PGI2MetaboliteLMFA03010087 (LIPID MAPS)
PGJ2MetaboliteLMFA03010019 (LIPID MAPS)
PLA2G4AProteinENSG00000116711 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18783
PLA2G4BProteinENSG00000243708 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:211429
PLA2G5ProteinENSG00000127472 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18784
PLA2G6ProteinENSG00000184381 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53357
PPAR gammaProteinAKA Peroxisome proliferator-activated receptor gamma
PPARDProteinENSG00000112033 (Ensembl)
  • AKA Peroxisome proliferator-activated receptor delta
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35396
PRXL2BProteinENSG00000157870 (Ensembl)
  • AKA Prxl2b
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9DB60
PTGDR2ProteinENSG00000183134 (Ensembl)
  • AKA Prostaglandin D2 receptor 2 (DP2 or CRTH2) [https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9Z2J6
PTGDRProteinENSG00000168229 (Ensembl)
  • AKA Prostaglandin D2 receptor 1 (DP1) [https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P70263
PTGDSProteinENSG00000107317 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19215
PTGESProteinENSG00000148344 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64292
PTGFRProteinENSG00000122420 (Ensembl)
  • AKA Prostaglandin F receptor (FP) [https://en.wikipedia.org/wiki/Prostaglandin_F_receptor]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43117
PTGIRProteinENSG00000160013 (Ensembl)
  • AKA Prostacyclin receptor, prostaglandin I2 receptor or just IP [https://en.wikipedia.org/wiki/Prostacyclin_receptor]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P43252
PTGISGeneProductENSG00000124212 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19223
PTGR1ProteinENSG00000106853 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67103
PTGR2ProteinENSG00000140043 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:77219
PTGS1ProteinENSG00000095303 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P22437
PTGS2ProteinENSG00000073756 (Ensembl)
  • AKA COX-2
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19225
TBXA2RProteinENSG00000006638 (Ensembl)
  • AKA thromboxane receptor (TP) also known as the prostanoid TP receptor [https://en.wikipedia.org/wiki/Thromboxane_receptor]
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P30987
TBXAS1GeneProductENSG00000059377 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21391
TXA2MetaboliteLMFA03030001 (LIPID MAPS)
TXB2MetaboliteLMFA03030002 (LIPID MAPS)
Tetranor-PGD2MetaboliteLMFA03010215 (LIPID MAPS)
Tetranor-PGE2MetaboliteLMFA03010211 (LIPID MAPS)
Tetranor-PGF2aMetaboliteLMFA03010213 (LIPID MAPS)
TxdhGeneProduct
delta-12-PGJ2MetaboliteLMFA03010020 (LIPID MAPS)

Annotated Interactions

No annotated interactions
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