Vitamin D-sensitive calcium signaling in depression (Homo sapiens)

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ER12Calcium pumpAntioxidant genesNMDA receptorVDR target genesHyperpolarizationOpenInsP3RdemethylasesDepressionHepatocyteNeuronSkinSunlightRXRAInflammatory cytokinesGGT1ATP2B4ATP2B3ITPR3G6PDKDM1BGSRGPXCHRM1KDM3AGCLCTPH2GRIN2BKDM6BGRIN2DITPR1CalbindinATP2B2Inositol 1,4,5-trisphosphatePVALBKetamineGRIN2CVitamin D pathwayTPH1GRIN1KDM1AITPR2ATP2B1CYP27A1GRM5GRIN2ADiacylglycerolglutamateVDREPLCAcetylcholineKCNQ2PIP2VDRH2O2KCNQ3SLC8A1Na+superoxide25(OH)D3Vitamin D3K+BCL2Ca2+Li+Vitamin D37-DehydrocholesterolCYP27B11,25-(OH)2D3CalbindinNFE2L2CACNA1CPMCAARECa2+Ca2+SLC8A1Ca2+KCNQ2KCNQ3ShutDepolarizationM-currentCACNA1CVDRNFE2L2Ca2+1,25-(OH)2D3VDR1,25-(OH)2D3RXRA


Description

Depression has been linked to (lack of) sunlight exposure and raised intracellular calcium levels. In this pathway, the role of the vitamin D pathway in calcium signaling in depression is shown. Active 1,25-dihydroxy-vitamin D3 is formed from 7-dehydrocholesterol by multiple conversion steps. It associates with RXR and VDR in the nucleus, which stimulates transcription of VDR target genes, resulting in lower intracellular calcium levels. Less sunlight exposure results in lower 1,25-dihydroxyvitamin D3 levels and therefore higher calcium levels.

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Ontology Terms

 

Bibliography

  1. Berridge MJ; ''Vitamin D and Depression: Cellular and Regulatory Mechanisms.''; Pharmacol Rev, 2017 PubMed Europe PMC
  2. Xuan Qin, Xin Wang; ''Role of vitamin D receptor in the regulation of CYP3A gene expression''; Acta Pharmaceutica Sinica B, 2019

History

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CompareRevisionActionTimeUserComment
107487view14:26, 14 October 2019LeonievdvenChanged visual elements, added complexes
107441view12:12, 8 October 2019LeonievdvenAdded groups/complexes and changed labels into properly annotated genes
107319view11:04, 23 September 2019EgonwInsP3R is a metabolite
106811view13:29, 17 September 2019MaintBotHMDB identifier normalization
106613view07:38, 12 September 2019LeonievdvenChanged secondary ChEBI identifiers to primary identifiers
106611view12:43, 11 September 2019Marvin M2Ontology Term : 'mental depression' added !
106610view12:38, 11 September 2019Marvin M2Ontology Term : 'altered calcium/calcium-mediated signaling pathway' added !
106565view15:06, 6 September 2019LeonievdvenModified description
106564view15:05, 6 September 2019LeonievdvenModified title
106563view15:04, 6 September 2019LeonievdvenModified description
106562view15:02, 6 September 2019LeonievdvenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1,25-(OH)2D3MetaboliteHMDB0000876 (HMDB)
25(OH)D3 MetaboliteHMDB0003550 (HMDB)
7-DehydrocholesterolMetaboliteCHEBI:17759 (ChEBI)
ARE
ATP2B1GeneProductENSG00000070961 (Ensembl)
ATP2B2GeneProductENSG00000157087 (Ensembl)
ATP2B3GeneProductENSG00000067842 (Ensembl)
ATP2B4GeneProductENSG00000058668 (Ensembl)
AcetylcholineMetaboliteCHEBI:15355 (ChEBI)
BCL2GeneProductENSG00000171791 (Ensembl)
CACNA1CGeneProductENSG00000151067 (Ensembl)
CHRM1GeneProductENSG00000168539 (Ensembl)
CYP27A1GeneProductENSG00000135929 (Ensembl)
CYP27B1GeneProductENSG00000111012 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CalbindinProteinP05937 (Uniprot-TrEMBL)
DiacylglycerolMetaboliteCHEBI:18035 (ChEBI)
G6PDGeneProductENSG00000160211 (Ensembl)
GCLCGeneProductENSG00000001084 (Ensembl)
GGT1GeneProductENSG00000100031 (Ensembl)
GPXProteinA0A087WT12 (Uniprot-TrEMBL)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductGRIN2A (HGNC)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductGRIN2C (HGNC)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GRM5GeneProductENSG00000168959 (Ensembl) Type your comment here
GSRGeneProductENSG00000104687 (Ensembl)
H2O2MetaboliteCHEBI:16240 (ChEBI)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Inflammatory cytokines Metabolite
Inositol 1,4,5-trisphosphateMetaboliteHMDB0001498 (HMDB)
K+MetaboliteCHEBI:29103 (ChEBI)
KCNQ2GeneProductENSG00000075043 (Ensembl)
KCNQ3GeneProductENSG00000184156 (Ensembl)
KDM1AGeneProductENSG00000004487 (Ensembl)
KDM1BGeneProductENSG00000165097 (Ensembl)
KDM3AGeneProductENSG00000115548 (Ensembl)
KDM6BGeneProductENSG00000132510 (Ensembl)
KetamineMetaboliteHMDB0015352 (HMDB)
Li+MetaboliteCHEBI:49713 (ChEBI)
NFE2L2GeneProductENSG00000116044 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PLCGeneProduct
PMCAComplex
PVALBGeneProductENSG00000100362 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SLC8A1GeneProductENSG00000183023 (Ensembl)
TPH1GeneProductENSG00000129167 (Ensembl)
TPH2GeneProductENSG00000139287 (Ensembl)
VDRE
VDRGeneProductENSG00000111424 (Ensembl)
Vitamin D pathwayPathwayWP2877 (WikiPathways)
Vitamin D3MetaboliteCHEBI:28940 (ChEBI)
glutamateMetaboliteCHEBI:14321 (ChEBI)
superoxideMetaboliteCHEBI:18421 (ChEBI)

Annotated Interactions

No annotated interactions

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