Serine Metabolism (Homo sapiens)

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13-Phosphoglycerate dehydrogenase deficiencyPSAT1PhosphatidylserineNAD+SHMTMg2+Methylene-THF3-PhosphoserineD-serineD-Glyceraldehyde 3-phosphatePHGDHGlycineTYMSPLPDHFRglucosepyruvateH+glycolysisPSPHSR3-PhosphohydroxypyruvateL-serineNADHglutamate2-KetoglutarateH2OPidTMPdUMPDHFTHFglycolysissphingolipidsceramidesPhosphoserine phosphatase deficiencyPhosphoserube aminotransferase deficiency


Description

This pathway shows disorders related to serine metabolism. Disorders resulting from an enzyme defect are highlighted in pink. This pathway was inspired by Chapter 5 (Figure 5.2) of the book of Blau (ISBN 3642403360 (978-3642403361)).

Quality Tags

Ontology Terms

 

Bibliography

  1. Blau N, Duran M, Gibson KM, Dionisi-Vici C; ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''; ISBN 3642403360, 2014

History

View all...
CompareRevisionActionTimeUserComment
107647view07:43, 25 October 2019DeSlUpdated layout
107634view15:35, 24 October 2019DeSlChanged complex for metabolites into group.
107633view15:34, 24 October 2019DeSlChanged complex of metabolites to group.
107632view15:34, 24 October 2019DeSlUpdated layout
107631view15:33, 24 October 2019DeSlUpdated secondary ChEBI IDs.
107540view18:13, 18 October 2019Khanspersadded xrefs
106455view09:50, 30 August 2019DeSlUpdated glycolysis PW ID
106454view09:49, 30 August 2019DeSlOntology Term : 'PSPH deficiency' added !
106453view09:49, 30 August 2019DeSlOntology Term : 'PSAT deficiency' added !
106452view09:47, 30 August 2019DeSlOntology Term : 'PHGDH deficiency' added !
106220view12:23, 16 August 2019AkutmonOntology Term : 'inherited metabolic disorder' added !
106219view12:20, 16 August 2019AkutmonOntology Term : 'serine metabolic pathway' added !
106218view12:17, 16 August 2019Akutmonchanged deaseases to labels
106217view12:14, 16 August 2019AkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-KetoglutarateMetaboliteCHEBI:30915 (ChEBI)
3-PhosphohydroxypyruvateMetaboliteCHEBI:18110 (ChEBI)
3-PhosphoserineMetaboliteCHEBI:37712 (ChEBI)
D-Glyceraldehyde 3-phosphateMetaboliteCHEBI:29052 (ChEBI)
D-serineMetaboliteCHEBI:35247 (ChEBI)
DHFMetabolite
DHFRGeneProductENSG00000228716 (Ensembl)
GlycineMetaboliteCHEBI:15428 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
L-serineMetaboliteCHEBI:17115 (ChEBI)
Methylene-THFMetabolite
Mg2+Metabolite
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
PHGDHGeneProductENSG00000092621 (Ensembl)
PLPMetabolite
PSAT1GeneProductENSG00000135069 (Ensembl)
PSPHGeneProductENSG00000146733 (Ensembl)
PhosphatidylserineMetaboliteCHEBI:18303 (ChEBI)
PiMetabolite
SHMTProtein
SRProtein
THFMetaboliteCHEBI:20506 (ChEBI)
TYMSGeneProductENSG00000176890 (Ensembl)
ceramidesMetaboliteCHEBI:17761 (ChEBI)
dTMPMetaboliteCHEBI:63528 (ChEBI)
dUMPMetaboliteCHEBI:17622 (ChEBI)
glucoseMetaboliteCHEBI:17234 (ChEBI)
glutamateMetaboliteCHEBI:14321 (ChEBI)
glycolysisPathwayWP4361 (WikiPathways)
glycolysisPathwayWP534 (WikiPathways)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
sphingolipidsMetaboliteCHEBI:26739 (ChEBI)

Annotated Interactions

No annotated interactions

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