ACE Inhibitor Pathway (Danio rerio)

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1Cell MembranerenAngiotensin IIagtr2Bradykininbdkrb2Angiotensin Inos3AldosteroneagtACE Inhibitoragtr1ace2kng1ace2


The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (

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Ontology Terms



  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC


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106087view11:59, 16 August 2019MaintBotHMDB identifier normalization
85436view09:40, 15 May 2016Egonw
85433view09:37, 15 May 2016EgonwQuick edit to datanode annotation or property
77438view20:25, 8 September 2014MaintBotremoved old homology label
77432view12:13, 8 September 2014Mkutmonupdated some gene labels
71512view19:21, 17 October 2013MaintBotAutomated update of data sources
68641view04:55, 6 July 2013MaintBotUpdated to 2013 gpml schema
67019view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57055view15:54, 20 January 2013EgonwUsed "PubChem-compound"
48313view04:38, 18 May 2012KhanspersUpdating PubChem xrefs
46426view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40809view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35054view10:34, 11 February 2010Thomasconnected lines
35053view10:32, 11 February 2010Thomasfixed annotations, added literature reference
35045view09:35, 11 February 2010Thomas
35037view09:28, 11 February 2010ThomasModified description
21664view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP468]]: Moved to stable identifier
12064view08:46, 15 May 2008MaintBotAdded to category $category
12062view08:46, 15 May 2008C.F.ThornUploaded new pathway

External references


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NameTypeDatabase referenceComment
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
AldosteroneMetaboliteC01780 (KEGG Compound)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
BradykininMetaboliteHMDB0004246 (HMDB)
ace2GeneProduct492331 (Entrez Gene)
agtGeneProduct322485 (Entrez Gene)
agtr1GeneProduct561935 (Entrez Gene)
agtr2GeneProduct503772 (Entrez Gene)
bdkrb2GeneProduct368199 (Entrez Gene)
kng1GeneProduct449808 (Entrez Gene)
renGeneProduct405786 (Entrez Gene)

Annotated Interactions

No annotated interactions

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