Amino Acid Metabolism Pathway Excerpt (Histidine catabolism extension) (Homo sapiens)

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rs74877811TCA cycleglutamate metabolismAconitateGLUD1OxaloacetateHALisocitrateCitrateHistidinePyruvateAlanineGPT2OxaloacetateSuccinyl-CoAFTCDSuccinateFumarateGlutamateMalate2-oxo-glutarateUROC1AMDHD1UCA4I-5PROANF-Glu


This pathway was created based on findings from the bachelor thesis project by Kristin Koppelmaa which investigated vitamin D GWAS results.

Thesis DOI:

This pathway shows an excerpt of the WikiPathways amino acid metabolism (WP3925) pathway containing the segment between the metabolites histidine and glutamate that was extended. The proteins added to the conversion were AMDHD1 and UROC1. Although the HAL and FTCD proteins were included in the amino acid metabolism pathway previously, the lead SNP rs7487782 which exists in both HAL and AMDHD1, was added to the pathway and linked to these two genes. This variant was mapped to these genes during the analysis of a dataset originating from PMID: 29343764.

Quality Tags

Ontology Terms



  1. Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP; ''''; , PubMed Europe PMC


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107181view14:26, 17 September 2019MaintBotChEBI identifier normalization
106809view13:28, 17 September 2019MaintBotHMDB identifier normalization
105101view11:44, 7 July 2019KrizzukasModified description
105092view16:02, 5 July 2019KrizzukasModified title
105080view12:09, 5 July 2019DeSlModified description
105079view12:09, 5 July 2019DeSlModified description
105078view12:08, 5 July 2019DeSlOntology Term : 'histidine degradation pathway' added !
105077view12:06, 5 July 2019DeSlUpdated lit. ref, connected SNP for layout, changed arrows to MIM-conversion if direction was given.
105076view12:03, 5 July 2019DeSlConnected GTP2 to fix unconnected lines.
105069view07:40, 4 July 2019EgonwUpdated the data source.
105063view13:49, 3 July 2019KrizzukasModified description
105062view13:47, 3 July 2019KrizzukasModified description
105061view13:42, 3 July 2019KrizzukasModified title
105060view13:40, 3 July 2019KrizzukasNew pathway

External references


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NameTypeDatabase referenceComment
2-oxo-glutarateMetaboliteCHEBI:16810 (ChEBI)
4I-5PROAMetaboliteCHEBI:27384 (ChEBI) trans-urocanic acid
AMDHD1GeneProductQ96NU7 (Uniprot-TrEMBL)
AconitateMetaboliteHMDB0000072 (HMDB)
AlanineMetaboliteHMDB0000161 (HMDB)
CitrateMetaboliteHMDB0000094 (HMDB)
FTCDGeneProductENSG00000160282 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962
FumarateMetaboliteHMDB0000134 (HMDB)
GLUD1GeneProductENSG00000148672 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753
GPT2GeneProductENSG00000166123 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391
GlutamateMetaboliteHMDB0000148 (HMDB)
HALGeneProductENSG00000084110 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010
HistidineMetaboliteHMDB0000177 (HMDB)
MalateMetaboliteHMDB0000156 (HMDB)
NF-GluMetaboliteCHEBI:18327 (ChEBI) trans-urocanic acid
OxaloacetateMetaboliteHMDB0000223 (HMDB)
PyruvateMetaboliteHMDB0000243 (HMDB)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
UCAMetaboliteCHEBI:30817 (ChEBI) trans-urocanic acid
UROC1GeneProductQ96N76 (Uniprot-TrEMBL) Dimer with NAD+
isocitrateMetaboliteHMDB0000193 (HMDB)

Annotated Interactions

No annotated interactions

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