Tryptophan metabolism (Homo sapiens)

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1Indole-3-acetaldoximeIndolepyruvate3-Hydroxy-L-kynurenine3-(2-Aminoethyl)-1H-indol-5-ol5-Hydroxyindolepyruvate6-Hydroxyindolelactate2-AminomuconateGlucobrassicinAnthranilateOxaloacetateIndole-3-acetateCinnavalininateIndole-3-ethanol4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate7,8-Dihydro-7,8-dihydroxykynurenate5-MethoxyindoleacetateIsophenoxazine3-IndoleglycolaldehydeFormyl-N-acetyl-5-methoxykynurenamine5-(2'-Formylethyl)-4,6-dihydroxypicolinate4,8-Dihydroxyquinoline8-Methoxykynurenate3-Methylindolepyruvate4-(2-Aminophenyl)-2,4-dioxobutanoateBenzoate degradation via hydroxylation2-Oxoadipate2-Formaminobenzoylacetate2-Aminomuconate2-Amino-3-carboxymuconateKynurenateN-formylanthranilate3-Hydroxyanthranilate5-HydroxyindoleacetylglycineL-Tryptophanyl-tRNA3-MethyldioxyindoleIndolelactate5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate2-Oxoglutarate3-Hydroxykynurenamine2,3-Dihydroxyindole5-Hydroxyindoleacetate6-HydroxykynurenateQuinolinate2-Formylaminobenzaldehyde3-MethoxyanthranilateFormyl-5-hydroxykynurenamineC011447,8-DihydroxykynurenateAnthranilate5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinIndole-3-acetaldehyde(Z)-5-Oxohex-2-enedioate5-hydroxykynurenamineN-acetylindoxylTryptamineASMTN-MethyltryptamineDDC3-Indoleacetonitrile4.1.1.-MAOBN-Methylserotonin3.5.1.91.14.99.2CYP1B1Melatonin2.1.1.472.6.1.271.13.12.3MAOBGlutaryl-CoAHRMT1L22-AminophenolALDH1A22.6.1.27ALDH3A2CYP2E11.13.11.-Crotonoyl-CoAWARSALDH1A11.1.1.1103.2.1.147MAOB4.1.1.43ALDH9A1AANAT1.3.1.181.10.3.4CYP19A12.6.1.27ASMTCYP4F12Acetyl-CoANicotinate and nicotinamide metabolismALDH2GCDH5-Hydroxy-L-tryptophanALDH9A1ALDH1A11.4.3.2AOX15-Hydroxyindoleacetaldehyde1.2.1.-CYP2A131.1.1.190ABP1Phenylalanine, Tyrosine and Tryptophan metabolismL-Kynurenine4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate3.5.1.4CYP2C18N-AcetylserotoninCyp2c12HRMT1L2CYP2J2CYP2F11.2.3.71.14.16.3DHCR24Cyp2d2TPH1L-TryptophanAADAT1.14.13.9Indole4.1.99.1ALDH1A2CATALDH2Benzoate degradation via hydroxylationTDO2MAOBCYP1A1Cyp2c395-(2'-Carboxyethyl)-4,6-DihydroxypicolinateCYP7B11.13.11.171.14.16.-HADHSC3.5.99.51.2.1.32Indole-3-acetamideCYP1A24,6-DihydroxyquinolineN-AcetylisatinXanthurenic acidGlycolysis/GluconeogenesisKYNU3.5.5.1AFMIDAcetoacetyl-CoA1.7.3.2ECHS1INDOAldh1a4CYP3A44.2.1.84FormylkynurenineOGDHDDCKYNU1.5.1.-ACAT13.5.1.49Cyp2a1AADAT1.13.99.31.1.1.191Aldh1a4HAAO5-Methoxytryptamine6-Hydroxymelatonin5-HydroxykynurenineHADH2ACMSD1.13.11.105-Hydroxy-N-formylkynurenineALDH3A2KYNUGCDHINDO2.1.1.49INDOCyp2b15INMTDDCHRMT1L2Cyp2a21.13.11.236.3.2.-


Description

This pathway describes the metabolism of tryptophan, an essential amino acid.

Converted from rat to human using ortholog information. Originally adapted from: KEGG.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+rno00380,

History

View all...
CompareRevisionActionTimeUserComment
106518view23:30, 5 September 2019Khanspersadded reference
106203view12:09, 16 August 2019MaintBotHMDB identifier normalization
105847view23:14, 15 August 2019KhanspersModified description
104898view15:43, 23 June 2019EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
104829view14:28, 19 June 2019Fehrhartadded some more metabolite IDs
104828view14:20, 19 June 2019Fehrhartadded metabolite IDs
104821view12:57, 19 June 2019FehrhartModified description
103977view02:10, 20 April 2019AlexanderPicoFixed EC6.3.2.-
102311view21:09, 17 December 2018KhanspersModified description
102310view21:08, 17 December 2018Khanspersremoved GenMAPP comment
94086view12:40, 18 August 2017DeSlModified description
93713view12:41, 11 August 2017DeSlModified description
85055view10:47, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
79226view18:51, 15 March 2015EgonwAdded a number of missing metabolite Chemspider identifiers (based on IUPAC names).
77387view12:04, 4 September 2014EgonwAdded a number of missing metabolite Chemspider identifiers (based on IUPAC names).
77384view13:24, 3 September 2014EgonwReplace a bunch of Labels for metabolites with Metabolite DataNodes.
71269view22:00, 16 October 2013MaintBotAutomated update of data sources
69003view17:45, 8 July 2013MaintBotUpdated to 2013 gpml schema
61696view23:21, 16 April 2013MaintBotspecified data source Enzyme Nomenclature for EC numbers
61691view22:33, 16 April 2013MaintBotremoved data source without identifer
45056view19:46, 6 October 2011KhanspersOntology Term : 'tryptophan metabolic pathway' added !
43616view14:09, 8 July 2011AdrienDefayadd database identifier for Gycolysis
41177view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38843view17:41, 24 September 2010Khanspers
38697view19:07, 23 September 2010KhanspersAdded pathway links and changed arrows
38695view19:00, 23 September 2010KhanspersPeriodical save, work in progress
38694view18:50, 23 September 2010KhanspersPeriodical save, work in progress
34449view18:21, 10 December 2009MaintBotAutomatic update of empty xrefs
33850view00:49, 9 December 2009KhanspersAdded metabolites and connectors
33849view00:47, 9 December 2009KhanspersPeriodical save, work in progress
33848view00:35, 9 December 2009KhanspersPeriodical save, work in progress
33820view00:24, 9 December 2009KhanspersPeriodical save, work in progress
32439view17:17, 15 August 2009MaintBotFixed text labels
32112view13:48, 14 August 2009MaintBotFixed group labels
30270view20:18, 25 July 2009AlexanderPicostill fixing unsupported characters
30269view20:16, 25 July 2009AlexanderPicofixed unsupported characters in TextLabels
30268view20:13, 25 July 2009AlexanderPico
30267view20:11, 25 July 2009AlexanderPicofixed unsupported characters in TextLabels
21658view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Tryptophane Metabolism KEGG]] moved to [[Pathway:WP465]]: Moved to stable identifier
14841view08:35, 24 May 2008AlexanderPicoConnected!
14839view08:27, 24 May 2008AlexanderPicoPeriodical save, work in progress
14835view08:16, 24 May 2008AlexanderPicoPeriodical save, work in progress
14833view08:06, 24 May 2008AlexanderPicoPeriodical save, work in progress
14830view07:56, 24 May 2008AlexanderPicoPeriodical save, work in progress
14828view07:46, 24 May 2008AlexanderPicoPeriodical save, work in progress
13127view11:18, 17 May 2008MaintBotautomated metabolite conversion
8464view13:46, 7 January 2008MaintBot[[Pathway:Human:Tryptophane Metabolism KEGG]] moved to [[Pathway:Homo sapiens:Tryptophane Metabolism KEGG]]: Renaming species
7848view16:22, 18 December 2007MaintBotfixed category names
7407view12:42, 4 November 2007MaintBotAdded categories to GPML
6402view22:18, 22 May 2007L.M.Ferrantegpml file for [[Human:Tryptophane_Metabolism_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Z)-5-Oxohex-2-enedioateMetabolite(Z)-5-Oxohex-2-enedioate
1.1.1.110GeneProduct1.1.1.110 (Enzyme Nomenclature)
1.1.1.190GeneProduct1.1.1.190 (Enzyme Nomenclature)
1.1.1.191GeneProduct1.1.1.191 (Enzyme Nomenclature)
1.10.3.4GeneProduct1.10.3.4 (Enzyme Nomenclature)
1.13.11.-GeneProduct1.13.11.- (Enzyme Nomenclature)
1.13.11.10GeneProduct1.13.11.10 (Enzyme Nomenclature)
1.13.11.17GeneProduct1.13.11.17 (Enzyme Nomenclature)
1.13.11.23GeneProduct1.13.11.23 (Enzyme Nomenclature)
1.13.12.3GeneProduct1.13.12.3 (Enzyme Nomenclature)
1.13.99.3GeneProduct1.13.99.3 (Enzyme Nomenclature)
1.14.13.9GeneProduct1.14.13.9 (Enzyme Nomenclature)
1.14.16.-GeneProduct1.14.16.- (Enzyme Nomenclature)
1.14.16.3GeneProduct1.14.16.3 (Enzyme Nomenclature)
1.14.99.2GeneProduct1.14.99.2 (Enzyme Nomenclature)
1.2.1.-GeneProduct1.2.1.- (Enzyme Nomenclature)
1.2.1.32GeneProduct1.2.1.32 (Enzyme Nomenclature)
1.2.3.7GeneProduct1.2.3.7 (Enzyme Nomenclature)
1.3.1.18GeneProduct1.3.1.18 (Enzyme Nomenclature)
1.4.3.2GeneProduct1.4.3.2 (Enzyme Nomenclature)
1.5.1.-GeneProduct1.5.1.- (Enzyme Nomenclature)
1.7.3.2GeneProduct1.7.3.2 (Enzyme Nomenclature)
2,3-DihydroxyindoleMetabolite20546 (Chemspider)
2-Amino-3-carboxymuconateMetabolite2-Amino-3-carboxymuconate
2-AminomuconateMetabolite2-Aminomuconate
2-AminophenolMetabolite95-55-6 (CAS) 2-Aminophenol
2-Formamino benzoylacetateMetabolite2-Formaminobenzoylacetate
2-FormylaminobenzaldehydeMetabolite389 (Chemspider)
2-OxoadipateMetabolite19951093 (Chemspider) 2-Oxoadipate
2-OxoglutarateMetabolite144236 (Chemspider) 2-Oxoglutarate
2.1.1.47GeneProduct2.1.1.47 (Enzyme Nomenclature)
2.1.1.49GeneProduct2.1.1.49 (Enzyme Nomenclature)
2.6.1.27GeneProduct2.6.1.27 (Enzyme Nomenclature)
3-(2-Aminoethyl) -1H-indol-5-olMetabolite5013 (Chemspider) 3-(2-Aminoethyl)-1H-indol-5-ol
3-Hydroxy- L-kynurenineMetabolite3-Hydroxy-L-kynurenine
3-HydroxyanthranilateMetabolite7822291 (Chemspider) 3-Hydroxyanthranilate
3-HydroxykynurenamineMetaboliteHMDB0060281 (HMDB) 3-Hydroxykynurenamine
3-IndoleacetonitrileMetabolite771-51-7 (CAS) 3-Indoleacetonitrile
3-IndoleglycolaldehydeMetabolite388979 (Chemspider)
3-MethoxyanthranilateMetabolite7827589 (Chemspider) 3-Methoxyanthranilate
3-MethyldioxyindoleMetaboliteCHEBI:28254 (ChEBI)
3-MethylindolepyruvateMetaboliteCHEBI:28549 (ChEBI) 3-Methylindolepyruvate
3.2.1.147GeneProduct3.2.1.147 (Enzyme Nomenclature)
3.5.1.4GeneProduct3.5.1.4 (Enzyme Nomenclature)
3.5.1.49GeneProduct3.5.1.49 (Enzyme Nomenclature)
3.5.1.9GeneProduct3.5.1.9 (Enzyme Nomenclature)
3.5.5.1GeneProduct3.5.5.1 (Enzyme Nomenclature)
3.5.99.5GeneProduct3.5.99.5 (Enzyme Nomenclature)
4,6-DihydroxyquinolineMetaboliteHMDB0004077 (HMDB)
4,8-DihydroxyquinolineMetaboliteCHEBI:28883 (ChEBI) 4,8-Dihydroxyquinoline
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateMetaboliteHMDB0004083 (HMDB)
4-(2-Amino-5-hydroxyphenyl) -2,4-dioxobutanoateMetabolite389617 (Chemspider) 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoateMetabolite19951260 (Chemspider) 4-(2-Aminophenyl)-2,4-dioxobutanoate
4.1.1.-GeneProduct4.1.1.- (Enzyme Nomenclature)
4.1.1.43GeneProduct4.1.1.43 (Enzyme Nomenclature)
4.1.99.1GeneProduct4.1.99.1 (Enzyme Nomenclature)
4.2.1.84GeneProduct4.2.1.84 (Enzyme Nomenclature)
5-(2'-Carboxyethyl)-4,6-DihydroxypicolinateMetaboliteHMDB0006794 (HMDB)
5-(2'-Formylethyl)-4,6-dihydroxypicolinateMetabolite30791294 (Chemspider) 5-(2'-Formylethyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinMetabolite5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateMetabolite30791292 (Chemspider) 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
5-Hydroxy-L-tryptophanMetaboliteHMDB0000472 (HMDB)
5-Hydroxy-N-formylkynurenineMetaboliteHMDB0004086 (HMDB)
5-HydroxyindoleacetaldehydeMetaboliteHMDB0004073 (HMDB)
5-HydroxyindoleacetateMetabolite10637170 (Chemspider) 5-Hydroxyindoleacetate
5-HydroxyindoleacetylglycineMetabolite
5-HydroxyindolepyruvateMetaboliteCHEBI:27597 (ChEBI)
5-HydroxykynurenineMetabolite484-78-6 (CAS)
5-MethoxyindoleacetateMetabolite14533147 (Chemspider) 5-Methoxyindoleacetate
5-MethoxytryptamineMetabolite608-07-1 (CAS)
5-hydroxykynurenamineMetaboliteCHEBI:62214 (ChEBI) 5-Hydroxykynurenamine
6-HydroxyindolelactateMetaboliteCHEBI:27524 (ChEBI) 6-Hydroxyindolelactate
6-HydroxykynurenateMetabolite6-Hydroxykynurenate
6-HydroxymelatoninMetabolite2208-41-5 (CAS)
6.3.2.-GeneProduct6.3.2.- (Enzyme Nomenclature)
7,8-Dihydro-7,8-dihydroxykynurenateMetabolite7,8-Dihydro-7,8-dihydroxykynurenate
7,8-DihydroxykynurenateMetabolite7,8-Dihydroxykynurenate
8-MethoxykynurenateMetabolite8-Methoxykynurenate
AADATGeneProduct51166 (Entrez Gene)
AANATGeneProduct15 (Entrez Gene)
ABP1GeneProduct26 (Entrez Gene)
ACAT1GeneProduct38 (Entrez Gene)
ACMSDGeneProduct130013 (Entrez Gene)
AFMIDGeneProduct125061 (Entrez Gene)
ALDH1A1GeneProduct216 (Entrez Gene)
ALDH1A2GeneProduct8854 (Entrez Gene)
ALDH2GeneProduct217 (Entrez Gene)
ALDH3A2GeneProduct224 (Entrez Gene)
ALDH9A1GeneProduct223 (Entrez Gene)
AOX1GeneProduct316 (Entrez Gene)
ASMTGeneProduct438 (Entrez Gene)
Acetoacetyl-CoAMetaboliteC00332 (KEGG Compound)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
Aldh1a4GeneProduct
AnthranilateMetabolite4573598 (Chemspider) Anthranilate
Benzoate degradation via hydroxylationPathway
C01144Metabolite(S)-3-Hydroxybutanoyl-CoA
CATGeneProduct847 (Entrez Gene)
CYP19A1GeneProduct1588 (Entrez Gene)
CYP1A1GeneProduct1543 (Entrez Gene)
CYP1A2GeneProduct1544 (Entrez Gene)
CYP1B1GeneProduct1545 (Entrez Gene)
CYP2A13GeneProduct1553 (Entrez Gene)
CYP2C18GeneProduct1562 (Entrez Gene)
CYP2E1GeneProduct1571 (Entrez Gene)
CYP2F1GeneProduct1572 (Entrez Gene)
CYP2J2GeneProduct1573 (Entrez Gene)
CYP3A4GeneProduct1576 (Entrez Gene)
CYP4F12GeneProduct66002 (Entrez Gene)
CYP7B1GeneProduct9420 (Entrez Gene)
CinnavalininateMetaboliteCinnavalininate
Crotonoyl-CoAMetaboliteC00877 (KEGG Compound)
Cyp2a1GeneProduct
Cyp2a2GeneProduct
Cyp2b15GeneProduct
Cyp2c12GeneProduct
Cyp2c39GeneProduct
Cyp2d2GeneProduct
DDCGeneProduct1644 (Entrez Gene)
DHCR24GeneProduct1718 (Entrez Gene) predicted
ECHS1GeneProduct1892 (Entrez Gene)
Formyl-5-hydroxykynurenamineMetaboliteHMDB0012948 (HMDB)
Formyl-N-acetyl-5- methoxykynurenamineMetaboliteFormyl-N-acetyl-5-methoxykynurenamine
FormylkynurenineMetabolite1022-31-7 (CAS) Formylkynurenine
GCDHGeneProduct2639 (Entrez Gene) predicted
GlucobrassicinMetaboliteGlucobrassicin
Glutaryl-CoAMetaboliteC00527 (KEGG Compound)
Glycolysis/GluconeogenesisPathwayWP534 (WikiPathways)
HAAOGeneProduct23498 (Entrez Gene)
HADH2GeneProduct3028 (Entrez Gene)
HADHSCGeneProduct3033 (Entrez Gene)
HRMT1L2GeneProduct3276 (Entrez Gene)
INDOGeneProduct3620 (Entrez Gene)
INMTGeneProduct11185 (Entrez Gene)
Indole-3-acetaldehydeMetabolite778 (Chemspider) Indole-3-acetaldehyde
Indole-3-acetaldoximeMetabolite388896 (Chemspider) Indole-3-acetaldoxime
Indole-3-acetamideMetabolite879-37-8 (CAS) Indole-3-acetamide
Indole-3-acetateMetabolite779 (Chemspider) Indole-3-acetate
Indole-3-ethanolMetabolite10235 (Chemspider)
IndoleMetabolite120-72-9 (CAS)
IndolelactateMetabolite28571995 (Chemspider) Indolelactate
IndolepyruvateMetabolite24775813 (Chemspider) Indolepyruvate
IsophenoxazineMetaboliteIsophenoxazine
KYNUGeneProduct8942 (Entrez Gene)
KynurenateMetaboliteCHEBI:18344 (ChEBI) 4-Hydroxy-2-quinolinecarboxylic
L-KynurenineMetabolite343-65-7 (CAS) L-Kynurenine
L-TryptophanMetabolite73-22-3 (CAS)
L-Tryptophanyl-tRNAMetabolite
MAOBGeneProduct4129 (Entrez Gene)
MelatoninMetaboliteHMDB0001389 (HMDB)
N-AcetylisatinMetabolite574-17-4 (CAS) N-Acetylisatin
N-AcetylserotoninMetabolite1210-83-9 (CAS) N-Acetylserotonin
N-MethylserotoninMetaboliteHMDB0004369 (HMDB)
N-MethyltryptamineMetaboliteCHEBI:28136 (ChEBI)
N-acetylindoxylMetaboliteCHEBI:15363 (ChEBI) N-Acetylindoxyl
N-formylanthranilateMetaboliteQ27103061 (Wikidata) Formylanthranilate
Nicotinate and nicotinamide metabolismPathway
OGDHGeneProduct4967 (Entrez Gene)
OxaloacetateMetabolite2509917 (Chemspider) Oxaloacetate
Phenylalanine, Tyrosine and Tryptophan metabolismPathway
QuinolinateMetabolite2777129 (Chemspider)
TDO2GeneProduct6999 (Entrez Gene)
TPH1GeneProduct7166 (Entrez Gene)
TryptamineMetabolite61-54-1 (CAS)
WARSGeneProduct7453 (Entrez Gene)
Xanthurenic acidMetaboliteHMDB0000881 (HMDB)

Annotated Interactions

No annotated interactions

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