Computational Model of Aerobic Glycolysis (Homo sapiens)

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ATPAMPO2eHHKGLUT1Applies to PKA and PKL; does not apply to PKMx 12.5_2PGBPGPYRGAPPGKENOATPGPILDHG6PLACCytosolExtracellular environmentPEPPK_3PGHGLUF6PDHAPALDPFKGLUeGAPDHADPFBPPGMTPIATPADPAMP3NADPNADHHATPADPATPADPLACeNADNADHLACTCytosolExtracellular environmentADPPATPO2x 12.5x 12.5x 3OXPHOSO2NADHMASx 2.5ADPPATPx 2.5x 2.5NADOXYTATPATPaseADPHPADPADPAKPYR2StimulationCatalysisConversionPathwayBranch pathway originatingfrom the glycolysisMetaboliteGlycolytic metaboliteEnzymeEnzyme or processNADPHATPChemicals; colour codedfor better visualisationEffector of the reactionpointed atConversion of acatalysing chemicalMetaboliteMetabolite that is fixedin the computer model


Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH.

This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of Shestov et al (2014). A second version, containing the content of the model itself as well as the corresponding supplement and article, can be found here [1]

This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [2]

Referred article: Shestov et al., 2014 [3]

Quality Tags

Ontology Terms

 

Bibliography

  1. Carbonell J, Felíu JE, Marco R, Sols A; ''''; , PubMed Europe PMC
  2. Hüttemann M, Lee I, Samavati L, Yu H, Doan JW; ''Regulation of mitochondrial oxidative phosphorylation through cell signaling''; https://www.sciencedirect.com/science/article/pii/S0167488907002364?via%3Dihub, 2007
  3. Berg JM, Tymoczko JL, Stryer L; ''Biochemistry''; https://www.ncbi.nlm.nih.gov/books/NBK22395/, 2002
  4. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107177view14:26, 17 September 2019MaintBotChEBI identifier normalization
106806view13:28, 17 September 2019MaintBotHMDB identifier normalization
105421view16:35, 7 August 2019DeSlRemoved unnecessary references.
105420view16:34, 7 August 2019DeSlUpdated lit. refs to remove weird characters.
105418view16:31, 7 August 2019DeSlConverted interactions in legend to graphical lines, to avoid unconnected lines warning.
104986view20:40, 27 June 2019KJanssenUpdated legend
104934view00:25, 26 June 2019AlexanderPicoModified title
104637view06:03, 7 June 2019EgonwIf there is no identifier, plz leave the Xref fields empty.
104617view08:09, 4 June 2019KJanssenModified description
104615view08:06, 4 June 2019KJanssen
104613view08:02, 4 June 2019KJanssenUpdated legend
104610view07:52, 4 June 2019KJanssenUpdated legend, minor changes in the pathway.
104607view07:18, 4 June 2019KJanssenModified title
104606view07:16, 4 June 2019KJanssenModified title
104601view16:53, 3 June 2019KJanssenModified description
104599view16:52, 3 June 2019KJanssenModified description
104598view16:51, 3 June 2019KJanssen
104597view16:48, 3 June 2019KJanssenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
AKGeneProduct
ALDGeneProduct226 (Entrez Gene)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPaseGeneProduct
BPGMetaboliteHMDB0001270 (HMDB)
DHAPMetaboliteHMDB0001473 (HMDB)
ENOGeneProduct2023 (Entrez Gene)
EnzymeGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
F6PMetaboliteCHEBI:61527 (ChEBI)
FBPMetaboliteHMDB0001058 (HMDB)
G6PMetaboliteCHEBI:75052 (ChEBI) Glucose-6-Phosphate (2-)
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPMetaboliteHMDB0001112 (HMDB)
GLUMetaboliteHMDB0000122 (HMDB)
GLUTGeneProduct6513 (Entrez Gene)
GLUeMetaboliteHMDB0000122 (HMDB)
GPIGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
HMetaboliteCHEBI:49637 (ChEBI)
HKGeneProduct3098 (Entrez Gene)
LACMetaboliteHMDB0000190 (HMDB)
LACTGeneProduct0 (Entrez Gene)
LACeMetaboliteHMDB0000190 (HMDB)
LDH GeneProduct3939 (Entrez Gene)
MAS
MetaboliteMetabolite
NADMetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
O2MetaboliteCHEBI:26689 (ChEBI)
O2eMetaboliteCHEBI:26689 (ChEBI)
OXPHOS
OXYT
PMetaboliteCHEBI:28659 (ChEBI)
PEPMetaboliteHMDB0000263 (HMDB)
PFKGeneProduct5213 (Entrez Gene) Type your comment here
PGK GeneProduct5230 (Entrez Gene)
PGM GeneProduct5224 (Entrez Gene)
PKGeneProduct5315 (Entrez Gene)
PYRMetaboliteHMDB0000243 (HMDB)
PathwayPathway0 (WikiPathways)
TPIGeneProduct7167 (Entrez Gene)
_2PGMetaboliteHMDB0000362 (HMDB)
_3PGMetaboliteHMDB0000807 (HMDB)

Annotated Interactions

No annotated interactions

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