Metabolism of alpha-linolenic acid (Homo sapiens)

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1Metabolite conversionElongaseFADS2Linoleic acidgamma-Linolenic acid12-HPEPEArachidonic acid 5-hydroperoxideArachidonic acid12-HETEDihomo-gamma-linolenic acid15-HETE15-HEPEFADS112-HEPE12-HPETEalpha-Linolenic acideicosapentaenoic aciddocosahexaenoic acidsElongaseFADS2FADS2FADS1LeukotrienesProstanoidsLXA4LXB4Prostaglandin G/H synthase 25-lipoxygenasePGH25-HPETE12-lipoxygenasePGG2Arachidonic acid5-HETE15-lipoxygenaseLTA412-lipoxygenaseCatalysisConversion mediated by a complexor a group of protiens


Metabolism of alpha-linolenic acid and linoleic acid to their respective acids. Both of these processes are catalyzed primarily by FADS1 and FADS2. The conversion of arachidonic acid to prostanoids is catalysed by prostaglandin G/H synthase 2 and the conversion of arachidonic acid to lipoxins is catalysed by different types of lipoxygenases.

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Ontology Terms



  1. Glen D. Lawrence; ''The Fats of Life: Essential Fatty Acids in Health and Disease''; 978-0-8135-4677-3, 2010


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119267view07:55, 23 June 2021FinterlyAdded ISBN for book citation
106804view13:28, 17 September 2019MaintBotHMDB identifier normalization
105271view21:19, 25 July 2019Khanspersconverted legend interactions to graphical lines
105095view19:05, 5 July 2019AlexanderPicoModified title
104813view11:26, 19 June 2019ChrisAdded legend
104629view05:41, 7 June 2019EgonwReplaced a secondary ChEBI ID with primary ID.
104623view10:29, 5 June 2019ChrisAdded new datanodes and changed protein annotations
104619view08:38, 5 June 2019ChrisAdded new datanodes and changes protein annotations
104585view10:48, 3 June 2019ChrisModified description
104584view10:39, 3 June 2019ChrisModified title
104583view10:25, 3 June 2019Chris- Added another pathway - Added pathway ontology eicosanoids
104582view10:11, 3 June 2019ChrisOntology Term : 'eicosanoid metabolic pathway' added !
104520view13:29, 29 May 2019ChrisOntology Term : 'alpha-linoleic acid metabolic pathway' added !
104519view13:19, 29 May 2019ChrisModified description
104518view13:17, 29 May 2019ChrisModified title
104510view12:52, 29 May 2019Chris-Combined two pathways -Changed annotations
104373view10:23, 22 May 2019DeSlOntology Term : 'PW:0001158' removed !
104372view10:23, 22 May 2019DeSlOntology Term : 'linoleic acid metabolic pathway' added !
104371view10:23, 22 May 2019DeSlOntology Term : 'PW:0000001' removed !
104370view10:23, 22 May 2019DeSlOntology Term : 'alpha-linoleic acid metabolic pathway' added !
104272view05:52, 15 May 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
104120view10:31, 6 May 2019ChrisOntology Term : 'Pathway Ontology' added !
104119view10:30, 6 May 2019ChrisModified title
104118view10:27, 6 May 2019ChrisNew pathway

External references


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NameTypeDatabase referenceComment
12-HEPEMetaboliteHMDB0010202 (HMDB)
12-HETEMetaboliteCHEBI:19138 (ChEBI)
12-HPEPEMetaboliteQ27148022 (Wikidata)
12-HPETE MetaboliteCHEBI:34145 (ChEBI)
12-lipoxygenaseProteinP18054 (Uniprot-TrEMBL)
15-HEPEMetaboliteHMDB0010209 (HMDB)
15-HETE MetaboliteCHEBI:63989 (ChEBI)
15-lipoxygenaseProteinP16050 (Uniprot-TrEMBL)
5-HETEMetaboliteCHEBI:65341 (ChEBI)
5-HPETEMetaboliteCHEBI:91268 (ChEBI)
5-lipoxygenaseProteinP09917 (Uniprot-TrEMBL)
Arachidonic acid 5-hydroperoxideMetaboliteCHEBI:91268 (ChEBI)
Arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
Dihomo-gamma-linolenic acidMetaboliteQ415398 (Wikidata)
FADS1ProteinO60427 (Uniprot-TrEMBL)
FADS2ProteinO95864 (Uniprot-TrEMBL)
LTA4MetaboliteCHEBI:15651 (ChEBI)
LXA4MetaboliteQ27082450 (Wikidata)
LXB4MetaboliteCHEBI:6499 (ChEBI)
Linoleic acidMetaboliteCHEBI:17351 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
Prostaglandin G/H synthase 2ProteinP35354 (Uniprot-TrEMBL)
alpha-Linolenic acidMetaboliteCHEBI:27432 (ChEBI)
docosahexaenoic acidsMetaboliteCHEBI:36005 (ChEBI)
eicosapentaenoic acidMetaboliteCHEBI:36006 (ChEBI)
gamma-Linolenic acidMetaboliteCHEBI:28661 (ChEBI)

Annotated Interactions

No annotated interactions

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