Canonical NF-KB pathway (Homo sapiens)

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1NucleusNFKB stimuliIKBKGRELRELAIKBKBCHUKNFKBIENFKB1NFKBIAPPPRELARELNFKB1NFKBIANFKBIERELANFKBIARELNFKB1NFKBIE


Description

The canonical NF-KB pathway is induced by the ligand-dependent activation of a variety of receptors. Stimulus-dependent activation of the IKK complex results in the phosphorylation and subsequent proteasomal degradation of IκBα and IκBε (NFKBIA and NFKBIE). This allows the nuclear translocation of transcriptionally active RelA/p50 (RELA, NFKB1) or c-Rel/p50 heterodimers (REL, NFKB1).

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Ontology Terms

 

Bibliography

  1. Grondona P, Bucher P, Schulze-OsthoffK, Hailfinger S, Schmitt A; ''NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.''; Biomedicines, 2018 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
104110view18:17, 4 May 2019AlexanderPicoModified description
104109view18:17, 4 May 2019AlexanderPicoModified title
104068view11:13, 1 May 2019Mkutmonunified to ensembl ids
104067view11:12, 1 May 2019Mkutmonunified to ensembl ids
103695view16:35, 28 March 2019MkutmonModified description
103694view16:35, 28 March 2019MkutmonModified description
103692view16:34, 28 March 2019MkutmonModified description
103691view16:34, 28 March 2019MkutmonOntology Term : 'nuclear factor kappa B signaling pathway' added !
103690view16:32, 28 March 2019MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CHUKGeneProductENSG00000213341 (Ensembl) IKKa
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl) IKKy
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIEGeneProductENSG00000146232 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl) RelA
RELGeneProductENSG00000162924 (Ensembl) c-Rel

Annotated Interactions

No annotated interactions

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