MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement (Homo sapiens)

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1Ovarian cancer cellEndothelial cellERNucleusCancer-associated fibroblastCancer-associated fibroblastECMMFAP5MYLKMAPK1TJP1JUNITPR1Calcium channelPTK2MYL2Ca2+ITGAVPPVCLPPPITGB3PTK2LPPACTN1CREB1PCREB1CREB1PLPPMAPK3PMAPK1MAPK3PXNLPPACTN1PLCG1PLCG1PPRKCQPRKCQPCa2+Ca2+Ca2+Endothelial cellITGAVITGB3TJP1LPPACTN1Cancer-associated fibroblastCa2+


Description

Proposed signaling pathways by which MFAP5 induces LPP expression and increases the permeability and motility of endothelial cells via cytoskeleton rearrangement.

The activation of the MFAP5-mediated signaling cascade in endothelial cells up-regulates LPP expression and subsequently promotes the motility of endothelial cells and the permeability of the endothelial cell monolayer.

Adapted from supplemental figure 11 from Leung et al.

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Ontology Terms

 

Bibliography

  1. Leung CS, Yeung TL, Yip KP, Wong KK, Ho SY, Mangala LS, Sood AK, Lopez-Berestein G, Sheng J, Wong ST, Birrer MJ, Mok SC; ''Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.''; J Clin Invest, 2018 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
103679view23:30, 27 March 2019KhanspersModified description
103677view22:14, 27 March 2019KhanspersModified title
103676view22:14, 27 March 2019KhanspersOntology Term : 'fibroblast' added !
103675view22:13, 27 March 2019KhanspersOntology Term : 'ovarian cancer' added !
103674view22:12, 27 March 2019KhanspersOntology Term : 'endothelial cell' added !
103673view22:11, 27 March 2019KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTN1GeneProductENSG00000072110 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:22984 (ChEBI)
Calcium channelGeneProduct
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LPPGeneProductENSG00000145012 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
MYL2GeneProductENSG00000111245 (Ensembl)
MYLKGeneProductENSG00000065534 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
PTK2GeneProductENSG00000169398 (Ensembl)
PXNGeneProductENSG00000089159 (Ensembl)
TJP1GeneProductENSG00000104067 (Ensembl)
VCLGeneProductENSG00000035403 (Ensembl)

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