MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement (Homo sapiens)

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1Ovarian cancer cellCancer-associated fibroblastERNucleusEndothelial cellCancer-associated fibroblastECMPTK2Calcium channelITPR1MYL2MFAP5ITGAVCa2+MAPK1MYLKTJP1JUNPPPPPVCLITGB3PTK2LPPACTN1CREB1CREB1PCREB1PLPPMAPK3PMAPK1MAPK3PXNLPPACTN1PLCG1PPLCG1PRKCQPPRKCQCa2+Ca2+Ca2+Endothelial cellITGAVITGB3TJP1LPPACTN1Cancer-associated fibroblastCa2+


Proposed signaling pathways by which MFAP5 induces LPP expression and increases the permeability and motility of endothelial cells via cytoskeleton rearrangement.

The activation of the MFAP5-mediated signaling cascade in endothelial cells up-regulates LPP expression and subsequently promotes the motility of endothelial cells and the permeability of the endothelial cell monolayer.

Adapted from supplemental figure 11 from Leung et al.

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Ontology Terms



  1. Leung CS, Yeung TL, Yip KP, Wong KK, Ho SY, Mangala LS, Sood AK, Lopez-Berestein G, Sheng J, Wong ST, Birrer MJ, Mok SC; ''Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.''; J Clin Invest, 2018 PubMed Europe PMC Scholia


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108134view10:31, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
103679view23:30, 27 March 2019KhanspersModified description
103677view22:14, 27 March 2019KhanspersModified title
103676view22:14, 27 March 2019KhanspersOntology Term : 'fibroblast' added !
103675view22:13, 27 March 2019KhanspersOntology Term : 'ovarian cancer' added !
103674view22:12, 27 March 2019KhanspersOntology Term : 'endothelial cell' added !
103673view22:11, 27 March 2019KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ACTN1GeneProductENSG00000072110 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:22984 (ChEBI)
Calcium channelGeneProduct
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LPPGeneProductENSG00000145012 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
MYL2GeneProductENSG00000111245 (Ensembl)
MYLKGeneProductENSG00000065534 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
PTK2GeneProductENSG00000169398 (Ensembl)
PXNGeneProductENSG00000089159 (Ensembl)
TJP1GeneProductENSG00000104067 (Ensembl)
VCLGeneProductENSG00000035403 (Ensembl)

Annotated Interactions

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