Interactions between immune cells and microRNAs in tumor microenvironment (Homo sapiens)

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1EVEVAPCEVLegendT cellEVMacrophageLymphocyteCancer cellRegulatoryT cellIFN-a/b SignalingLymphocytes conversion to regulatory T cells in immunosuppressive microenvironmentLPSTRAMHCMIR155IL2RASOCS1MRX34TLR4TGFBR2CTLA4CD80CD86MIR138-1MIR138-2PDCD1MIR212MIR203AMIR203BMRG-106(cobomarsen)MIR34AMIR138-1MIR138-2CD274MIR200AMIR200BMIR200CMIR155MIR21PIAS3STAT3CCL5CXCL10CCL2TGFB1TGFB2TGFB3IL2RBIL2RGTRBCCL5CXCL10MIR24-1MIR24-2MIR214CCL2Th1 cellMIRLET7DNKMIR210MIR23AEVMIR21MIR29AIRAK4TRAF6MIR21STAT3MIR24-2MIR23AMIR27ASTAT6MIR146ATLR7TLR8NFKB1NFKB2IL4IL4REVExtracellular vesicle


Description

The interplay between immune cells and microRNAs in the tumor microenvironment (TME). MRX34 and MRG‐106 (cobomarsen) are miRNA therapeutic agents. Adapted from figure 1 in Cortez et al.

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Ontology Terms

 

Bibliography

  1. Cortez MA, Anfossi S, Ramapriyan R, Menon H, Atalar SC, Aliru M, Welsh J, Calin GA; ''Role of miRNAs in immune responses and immunotherapy in cancer.''; Genes Chromosomes Cancer, 2019 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
104316view20:00, 16 May 2019Khanspersconnected interaction
103720view12:55, 29 March 2019DeSlReplaces secondary ChEBI with primary ID.
103696view19:54, 28 March 2019KhanspersChanged layout to accomodate legend
103678view23:10, 27 March 2019Khanspersadded legend
103672view00:02, 27 March 2019KhanspersModified description
103671view00:00, 27 March 2019KhanspersOntology Term : 'antigen processing and presentation pathway' added !
103670view23:59, 26 March 2019KhanspersOntology Term : 'natural T-regulatory cell' added !
103669view23:59, 26 March 2019KhanspersOntology Term : 'lymphocyte' added !
103668view23:59, 26 March 2019KhanspersOntology Term : 'T cell' added !
103667view23:59, 26 March 2019KhanspersOntology Term : 'macrophage' added !
103666view23:58, 26 March 2019KhanspersOntology Term : 'natural killer cell' added !
103665view23:58, 26 March 2019KhanspersOntology Term : 'immune response pathway' added !
103664view23:57, 26 March 2019KhanspersOntology Term : 'cancer' added !
103663view21:38, 26 March 2019KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCL2GeneProductENSG00000108691 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CD274GeneProductENSG00000120217 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CTLA4GeneProductENSG00000163599 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
IL2RAGeneProductENSG00000134460 (Ensembl)
IL2RBGeneProductENSG00000100385 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL4RGeneProductENSG00000077238 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
LPSMetaboliteCHEBI:52603 (ChEBI)
MHCGeneProduct
MIR138-1GeneProductENSG00000207954 (Ensembl)
MIR138-2GeneProductENSG00000207649 (Ensembl)
MIR146AGeneProductENSG00000283733 (Ensembl)
MIR155RnaENSG00000283904 (Ensembl)
MIR200AGeneProductMIR200A (HGNC)
MIR200BGeneProductENSG00000207730 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR203AGeneProductENSG00000207568 (Ensembl)
MIR203BGeneProductENSG00000283165 (Ensembl)
MIR210GeneProductENSG00000199038 (Ensembl)
MIR212GeneProductENSG00000267195 (Ensembl)
MIR214GeneProductENSG00000283844 (Ensembl)
MIR21GeneProductENSG00000284190 (Ensembl)
MIR23AGeneProductENSG00000207980 (Ensembl)
MIR24-1GeneProductENSG00000284459 (Ensembl)
MIR24-2GeneProductENSG00000284387 (Ensembl)
MIR27AGeneProductENSG00000207808 (Ensembl)
MIR29AGeneProductENSG00000284032 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIRLET7DGeneProductENSG00000199133 (Ensembl)
MRG-106 (cobomarsen)Metabolite
MRX34Metabolite
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
PDCD1GeneProductENSG00000188389 (Ensembl)
PIAS3GeneProductENSG00000131788 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TRAGeneProduct6955 (Entrez Gene)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRBGeneProduct6957 (Entrez Gene)

Annotated Interactions

No annotated interactions

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