Overview of interferons-mediated signaling pathway (Homo sapiens)

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Interferons (IFNs) can be devided in three classes, Type I, II and III. Type I IFNs are created when the cell surface or specific receptors recognize microbial products; these are structural homologues of one another which bind the same receptor. Binding to this receptor leads to an activation of kinases which regulate the phosphorylation and therefore activation of some STAT proteins (see PW for details).

There is only 1 Type II interferon, INF-gamma, consisting of two subunits (R1 and R2), which associate with Jak 1 and 2, respectively. Activation of Jak1 and Jak2 leads to phosphorylation of STAT1, which ultimately binds to IFN-gamma-activated sequence (GAS) elements, regulating the transcription of genes.

Type III interferons are considered a protein family of 4, which bind to a different receptor compared to Type I interferons, however they trigger the same STAT1+2 phosphorylation reactions as TypeI IFNs.

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Ontology Terms



  1. Mesev EV, LeDesma RA, Ploss A; ''Decoding type I and III interferon signalling during viral infection.''; Nat Microbiol, 2019 PubMed Europe PMC Scholia
  2. Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I; ''Direct effects of type I interferons on cells of the immune system.''; Clin Cancer Res, 2011 PubMed Europe PMC Scholia
  3. Platanias LC; ''Mechanisms of type-I- and type-II-interferon-mediated signalling.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia


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107928view21:17, 11 November 2019Khanspersconnected interaction
107748view16:34, 31 October 2019DeSlModified description
107747view16:33, 31 October 2019DeSlAdded lit. refs for type I, II and III (on the groups).
107746view16:26, 31 October 2019DeSlOntology Term : 'type II interferon signaling pathway' added !
107745view16:26, 31 October 2019DeSlOntology Term : 'type I interferon signaling pathway' added !
107744view16:25, 31 October 2019DeSlModified description
107743view16:24, 31 October 2019DeSlModified description
107742view16:22, 31 October 2019DeSlModified description
107737view13:45, 31 October 2019DeSlModified description
107736view13:42, 31 October 2019DeSlModified description
107735view13:40, 31 October 2019DeSlLayout
107734view13:38, 31 October 2019DeSlConverted lines to graphical lines where needed.
107733view13:36, 31 October 2019DeSlUpdated colour of phosphorylation (so it will not interfere with data)
103729view20:38, 31 March 2019AndraOntology Term : 'signaling pathway' added !
103635view16:45, 22 March 2019AzkalatyGraphical update
103634view16:41, 22 March 2019AzkalatyGraphical changes
103633view16:38, 22 March 2019AzkalatyGraphical update
103632view16:35, 22 March 2019AzkalatyModified title
103631view16:34, 22 March 2019AzkalatyUpdated organization
103629view11:53, 22 March 2019AzkalatyAdded new molecules
103617view16:14, 21 March 2019AzkalatyModified title
103616view16:14, 21 March 2019AzkalatyModified title
103615view15:57, 21 March 2019AzkalatyNew pathway

External references


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NameTypeDatabase referenceComment
IFNA10GeneProduct3446 (Entrez Gene)
IFNA13GeneProduct3447 (Entrez Gene)
IFNA1GeneProduct3439 (Entrez Gene)
IFNA14GeneProduct3448 (Entrez Gene)
IFNA16GeneProduct3449 (Entrez Gene)
IFNA17GeneProduct3451 (Entrez Gene)
IFNA21GeneProduct3452 (Entrez Gene)
IFNA2GeneProduct3440 (Entrez Gene)
IFNA4GeneProduct3441 (Entrez Gene)
IFNA5GeneProduct3442 (Entrez Gene)
IFNA6GeneProduct3443 (Entrez Gene)
IFNA7GeneProduct3444 (Entrez Gene)
IFNA8GeneProduct3445 (Entrez Gene)
IFNAR1GeneProduct3454 (Entrez Gene)
IFNAR2GeneProduct3455 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IFNEGeneProduct338376 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IFNGR1GeneProduct3459 (Entrez Gene)
IFNGR2GeneProduct3460 (Entrez Gene)
IFNKGeneProduct56832 (Entrez Gene)
IFNL1GeneProduct282618 (Entrez Gene)
IFNL2GeneProduct282616 (Entrez Gene)
IFNL3GeneProduct282617 (Entrez Gene)
IFNL4GeneProduct101180976 (Entrez Gene)
IFNLR1GeneProduct163702 (Entrez Gene)
IFNW1GeneProduct3467 (Entrez Gene)
IL10RBGeneProduct3588 (Entrez Gene)
IRF9GeneProduct10379 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)

Annotated Interactions

No annotated interactions

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