Cysteine and methionine catabolism (Homo sapiens)

From WikiPathways

Jump to: navigation, search
21Transsulfuration pathwayCysteine sulfinic acidMSSulfite3-Mercaptopyruvic acidgamma-GlutamylcysteineAAT5-MethyltetrahydrofolateMATCystathioninealpha-KBMethionineBetainePyrGCSSORSSHH2SSulfateATPS2O3 (2-)CystineCysteineS-AdenosylmethionineCSEGSSQRHomocysteineGluCSEMPSTTetra-hydrofolate-CH3S-sulfocysteineCDOH2OCO2DimethylglycineSO3 2-MTHypotaurineserineKGTaurineO2BHMTS-AdenosylhomocysteineSAAHGlutathioneB-Sulfinyl pyruvateAATSTCSDH2SAdenosineNH3CSEKGGluCSEGluGlySQRSDOSOOxidative cysteine pathwayNon-Oxidative cysteine pathway


Description

This pathway visualises the conversion of methionine to cysteine, after which it is further metabolised in either an oxidative or non-oxidative manner.

Several of these metabolites are altered in people suffering from MoCD and SO; changes in metabolite concentrations (comparing MoCD cases to controls) are highlighted in blue (see [1] for the pathway on MoCD).

This pathway was inspired by Chapter 12 of the book of Blau (ISBN 978-3-642-40337-8).

Quality Tags

Ontology Terms

 

Bibliography

  1. Miyamoto R, Otsuguro K, Yamaguchi S, Ito S; ''Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons.''; J Neurochem, 2014 PubMed
  2. Nenad Blau, Marinus Duran, K Michael Gibson, Carlo Dionisi-Vici; '''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''; Springer-Verlag Berlin Heidelberg, 2014

History

View all...
CompareRevisionActionTimeUserComment
102835view20:44, 24 January 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
102826view15:47, 24 January 2019DeSlModified description
102812view15:19, 24 January 2019DeSlAnother small layout change
102811view15:18, 24 January 2019DeSlChanged layout
102810view15:17, 24 January 2019DeSlChanged Enzyme nomenclature ID to Uniprot for SO
102799view13:57, 24 January 2019DeSlOntology Term : 'methionine degradation pathway' added !
102798view13:56, 24 January 2019DeSlOntology Term : 'methionine cycle/metabolic pathway' added !
102797view13:56, 24 January 2019DeSlOntology Term : 'cysteine metabolic pathway' added !
102796view13:56, 24 January 2019DeSlOntology Term : 'cysteine and methionine metabolic pathway' added !
102795view13:54, 24 January 2019DeSlModified description
102794view13:52, 24 January 2019DeSlAdded in- and decreased metabolites related to MoCD.
102793view13:48, 24 January 2019DeSlAnnotated RSSH
102791view13:44, 24 January 2019DeSlChanged layout according to lit. ref
102790view13:40, 24 January 2019DeSlAnnotated several proteins (bottom)
102789view13:34, 24 January 2019DeSlLayout update
102788view13:33, 24 January 2019DeSlUpdated other missing reactions
102786view12:02, 24 January 2019DeSlAdded more side metabolites
102785view10:53, 24 January 2019DeSlmore layout changes, added side metabolites to left bottom side of PW.
102784view10:31, 24 January 2019DeSlChanged layout top, annotated side metabolites top
102749view07:16, 23 January 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
102747view13:35, 22 January 2019DeSlAdded several side metabolites, and lit. ref.
102741view16:36, 21 January 2019DeSlModified description
102740view16:34, 21 January 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
-CH3MetaboliteCHEBI:32875 (ChEBI)
3-Mercaptopyruvic acidMetaboliteCHEBI:16208 (ChEBI)
5-Methyl tetrahydrofolateMetaboliteCHEBI:15641 (ChEBI)
AATProteinA0A140VK69 (Uniprot-TrEMBL) AKA Aspartate aminotransferase
ATPMetaboliteCHEBI:15422 (ChEBI)
AdenosineMetaboliteCHEBI:16335 (ChEBI)
B-Sulfinyl pyruvateMetaboliteHMDB02332 (HMDB)
BHMTProteinE5RJH0 (Uniprot-TrEMBL) AKA Betaine--homocysteine S-methyltransferase 1
BetaineMetaboliteCHEBI:17750 (ChEBI)
CDOProteinQ16878 (Uniprot-TrEMBL) Cysteine dioxygenase type 1
CO2MetaboliteCHEBI:16526 (ChEBI)
CSDProteinF8WCW3 (Uniprot-TrEMBL) AKA Cysteine sulfinic acid decarboxylase
CSEProteinP32929 (Uniprot-TrEMBL) Cystathionine gamma-lyase
CSEProteinP35520 (Uniprot-TrEMBL) aka Cystathionine beta-synthase
CystathionineMetaboliteCHEBI:17482 (ChEBI)
Cysteine sulfinic acid MetaboliteCHEBI:61085 (ChEBI)
CysteineMetaboliteCHEBI:15356 (ChEBI)
CystineMetaboliteCHEBI:17376 (ChEBI)
DimethylglycineMetaboliteHMDB00092 (HMDB)
GCSProteinQ14TF0 (Uniprot-TrEMBL) AKA Glutamate-cysteine ligase
GSProteinP48637 (Uniprot-TrEMBL) AKA Glutathione synthetase
GluMetaboliteCHEBI:28300 (ChEBI) AKA glutamine
GlutathioneMetaboliteCHEBI:16856 (ChEBI)
GlyMetaboliteCHEBI:15428 (ChEBI) AKA glycine
H2OMetaboliteCHEBI:15377 (ChEBI)
H2SMetaboliteCHEBI:16136 (ChEBI) aka Hydrogen sulfide
HomocysteineMetaboliteCHEBI:17230 (ChEBI)
HypotaurineMetaboliteCHEBI:16668 (ChEBI)
KGMetaboliteCHEBI:16810 (ChEBI) aka a-ketoglutarate (a-KG)
MATGeneProduct2.5.1.6 (BRENDA) aka Methionine adenosyltransferase
MPSTProteinP25325 (Uniprot-TrEMBL) AKA 3-mercaptopyruvate sulfurtransferase
MSProteinQ99707 (Uniprot-TrEMBL) AKA Methionine synthase
MTGeneProduct2.1.1 (BRENDA) AKA Methyltransferase
MethionineMetaboliteCHEBI:16643 (ChEBI)
NH3MetaboliteCHEBI:16134 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PyrMetaboliteCHEBI:32816 (ChEBI) AKA Pyruvic acid
RSSHMetaboliteCHEBI:30605 (ChEBI) AKA persulfurated thiol-containing compound (RSSH)
S-AdenosylhomocysteineMetaboliteCHEBI:16680 (ChEBI)
S-AdenosylmethionineMetaboliteCHEBI:67040 (ChEBI)
S-sulfocysteineMetaboliteCHEBI:27891 (ChEBI)
S2O3 (2-)MetaboliteQ410739 (Wikidata) AKA thiosulfate ion
SAAHProteinA0A024R0A8 (Uniprot-TrEMBL) Adenosylhomocysteinase
SDOProteinO95571 (Uniprot-TrEMBL) AKA sulfur dioxygenase
SOGeneProduct1.8.3.1 (BRENDA) AKA Sulfite oxidase
SO3 2-MetaboliteQ413363 (Wikidata) AKA sulfite ion.
SOGeneProductP51687 (Uniprot-TrEMBL) AKA Sulfite oxidase
SQRProteinQ9Y6N5 (Uniprot-TrEMBL)
STProteinAKA sulfur transferase
SulfateMetaboliteHMDB01448 (HMDB)
SulfiteMetaboliteCHEBI:26823 (ChEBI)
TaurineMetaboliteCHEBI:15891 (ChEBI)
Tetra- hydrofolateMetaboliteCHEBI:20506 (ChEBI)
alpha-KBMetabolite
gamma-GlutamylcysteineMetaboliteCHEBI:17515 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)

Annotated Interactions

No annotated interactions

Personal tools