Selective expression of chemokine receptors during T-cell polarization (Homo sapiens)

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1Th1 cellTh0 cellResevoir of semi naive T cells (Tsn)Dendritic cellMacrophageNK1+CD4+/CD4-8-TcrAB+Tsn cellTh2 cellCCL3CXCR4IFNGIL12BIL12ATGFB2TGFB1IL2IL4CCR7IL5CCL4CD4TGFB3CSF2CD28CD40LGIL12RB1IL12RB2IL18R1IL12RB1IL12RB2IL4RCD28CD40LGIFNGR1IFNGR2IL4IL2CCR3CCR4CXCR3CCR2CCR1CCR5CCR3CCR4CCR2IL12BIL12AIL12BIL12AIL12BIL12AIFNG


Description

Selective expression of chemokine receptors during T-cell polarization.

Pathway based on Biocarta pathway (M4047). https://cgap.nci.nih.gov/Pathways/BioCarta/h_nktPathway

The polarization of T cells into Th1 and Th2 cells is associated with their expression of subsets of chemokine receptors. While not being exposed to antigens, naïve T cells express CXCR4 and CCR7 receptors. TGF-beta van induce semi-naive T cells, that express a subset of CCR4 and CCR7 receptors. Th1 express CXCR3, CCR1, CCR2 and CCR5 receptors, while Th2 express CCR2, CCR3 and CCR5. However these subsets are not absolute as there is overlap between the expression of receptor subsets and thus between Th1 and Th2 cells.

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Ontology Terms

 

Bibliography

  1. de Jong EC, Smits HH, Kapsenberg ML; ''Dendritic cell-mediated T cell polarization.''; Springer Semin Immunopathol, 2005 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
103559view12:14, 14 March 2019Mkutmoncorrected special character in title
102691view15:40, 19 January 2019FehrhartOntology Term : 'chemokine mediated signaling pathway' added !
102690view15:40, 19 January 2019FehrhartOntology Term : 'T cell' added !
102662view12:15, 16 January 2019LaurentModified description
102657view10:16, 16 January 2019LaurentAdded reference
102645view08:53, 16 January 2019LaurentFixed interactions
102620view13:04, 14 January 2019LaurentNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCL3GeneProduct6348 (Entrez Gene)
CCL4GeneProduct6351 (Entrez Gene)
CCR1GeneProduct1230 (Entrez Gene)
CCR2GeneProduct729230 (Entrez Gene)
CCR3GeneProduct1232 (Entrez Gene)
CCR4GeneProduct1233 (Entrez Gene)
CCR5GeneProduct1234 (Entrez Gene)
CCR7GeneProduct1236 (Entrez Gene)
CD28GeneProduct940 (Entrez Gene)
CD40LGGeneProduct959 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CSF2GeneProduct1437 (Entrez Gene)
CXCR3GeneProduct2833 (Entrez Gene)
CXCR4GeneProduct7852 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IFNGR1GeneProduct3459 (Entrez Gene)
IFNGR2GeneProduct3460 (Entrez Gene)
IL12AGeneProduct3592 (Entrez Gene)
IL12BGeneProduct3593 (Entrez Gene)
IL12RB1GeneProduct3594 (Entrez Gene)
IL12RB2GeneProduct3595 (Entrez Gene)
IL18R1GeneProduct8809 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL4RGeneProduct3566 (Entrez Gene)
IL5GeneProduct3567 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)

Annotated Interactions

No annotated interactions

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