Resistin as a regulator of inflammation (Homo sapiens)

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1, 2IP3NucleusMAPK CascadeCa2+Unknown receptorCytosolDNAEndoplasmic reticulumCalcium channelIL6AKT3PLCD3TNFAKT1p38NFkBIL12AIkBAPLCB3PI3KAERK1PLCG2IkKBIkKGIL8IL12BPLCD1PI3KGITP3RPI3KBPLCB1IkKAAKT2PLCB4PLCD4PLCB2RETNPLCG1ERK2RELAPI3KDPLCE1NFkBIkBARELANFkBRELAPCa2+Ca2+


Description

Resistin induced intracellular signaling pathways. No receptor for resistin has yet been identified. Resistin induces NF-kB activity. Resistin increases the cytosolic Ca concentration via both PLC activation, leading to the release of Ca from intracellular pools, such as the endoplasmic reticulum, and Ca influx from the extracellular environment. Activation of the abovementioned signaling pathways via resistin suggests that it has proinflammatory potential.

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Bibliography

  1. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed
  2. Filková M, Haluzík M, Gay S, Senolt L; ''The role of resistin as a regulator of inflammation: Implications for various human pathologies.''; Clin Immunol, 2009 PubMed

History

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CompareRevisionActionTimeUserComment
102529view01:29, 4 January 2019Khanspersconnected interactions
102273view22:31, 16 December 2018AndraOntology Term : 'disease by infectious agent' added !
102272view22:30, 16 December 2018AndraOntology Term : 'altered regulatory pathway' added !
102271view22:28, 16 December 2018Andraconnected lines
102251view09:55, 13 December 2018LaurentModified description
102250view09:55, 13 December 2018LaurentModified description
102249view09:54, 13 December 2018LaurentNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
IL12AGeneProduct3592 (Entrez Gene)
IL12BGeneProduct3593 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
ITP3RGeneProduct3708 (Entrez Gene)
IkBAGeneProduct4792 (Entrez Gene)
IkKAGeneProduct1147 (Entrez Gene)
IkKBGeneProduct3551 (Entrez Gene)
IkKGGeneProduct8517 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
PI3KAGeneProduct5290 (Entrez Gene)
PI3KBGeneProduct5291 (Entrez Gene)
PI3KDGeneProduct5293 (Entrez Gene)
PI3KGGeneProduct5294 (Entrez Gene)
PLCB1GeneProduct23236 (Entrez Gene)
PLCB2GeneProduct5330 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
PLCB4GeneProduct5332 (Entrez Gene)
PLCD1GeneProduct5333 (Entrez Gene)
PLCD3GeneProduct113026 (Entrez Gene)
PLCD4GeneProduct84812 (Entrez Gene)
PLCE1GeneProduct51196 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLCG2GeneProduct5336 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RETNGeneProduct56729 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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