Steroidogenic pathway (Homo sapiens)

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1Capillaries/ExtracellularfluidTheca CellInteractions legend:Transport into or between cell(s).Granulosa CellReceptor?LDLFSHATPFSH siganlling pathwayCholesterolSTARLHAromataseCholesterolPregnenoloneDHEAProgesteroneProgesteroneCholesterolPregnenoloneAndrostenedioneAndrostenedioneTestosteroneTestosteroneEstroneEstradiolMolecular conversion.Conversion is catalysed by protein.CYP11A1HSD3B1CYP17A1CYP17A1HSD3B1HSD17B1CYP11A1HSD3B1HSD17B1CYP19A1CYP19A1Receptor?HSD17B1Receptor?Receptor?Binding interaction.ACReceptor?ACcAMPATPcAMP


Description

This pathway describes the production of female sex steroid hormones, which is known as steroidogenesis. Two cell types are involved: theca and granulosa cells.

The final product for this pathway are estrogens (among others 17-beta-estradiol), which are produced from cholesterol. In the theca cell, this process is controlled by the luteinizing hormone (LH), after which androgen molecules diffuse into the granulosa cells.

When the follicles reach maturity, the follicle-stimulating hormone (FSH) stimulates the granulosa cell to convert androgens to estrogens.

Quality Tags

Ontology Terms

 

Bibliography

  1. Patel S, Zhou C, Rattan S, Flaws JA; ''Effects of Endocrine-Disrupting Chemicals on the Ovary.''; Biol Reprod, 2015 PubMed

History

View all...
CompareRevisionActionTimeUserComment
102314view15:47, 18 December 2018EgonwReplaced a secondary ChEBI ID with primary ID.
102276view23:08, 16 December 2018Andraupdated some IDs
101864view16:12, 14 November 2018DeSlAdded link to FSH signaling PW.
101863view16:09, 14 November 2018DeSlAdded signaling part, changed layout slightly
101862view15:54, 14 November 2018DeSlOntology Term : 'granulosa cell' added !
101861view15:54, 14 November 2018DeSlOntology Term : 'theca cell' added !
101860view15:53, 14 November 2018DeSlOntology Term : 'estradiol biosynthetic pathway' added !
101859view15:52, 14 November 2018DeSlModified description
101858view15:46, 14 November 2018DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACProteinaka adenylate cyclase
ATPMetabolite
AndrostenedioneMetabolite
AndrostenedioneMetaboliteCHEBI:16422 (ChEBI)
AromataseProteinP11511 (Uniprot-TrEMBL)
CYP11A1GeneProductCYP11A1 (HGNC)
CYP11A1GeneProductENSG00000140459 (Ensembl)
CYP17A1GeneProductENSG00000148795 (Ensembl)
CYP19A1GeneProductENSG00000137869 (Ensembl)
CholesterolMetabolite
DHEAMetabolite
EstradiolMetabolite
EstroneMetabolite
FSH

siganlling

pathway
PathwayWP2035 (WikiPathways)
FSHMetaboliteCHEBI:81569 (ChEBI) aka follicle-stimulating hormone
HSD17B1Protein
HSD17B1GeneProductENSG00000108786 (Ensembl)
HSD17B1GeneProductHSD17B1 (HGNC) aka luteinizing hormone
HSD3B1GeneProductENSG00000203857 (Ensembl)
LDLProteinaka low-density lipoproteins
LHProteinaka luteinizing hormone
PregnenoloneMetabolite
ProgesteroneMetabolite
Receptor?Protein
STARProtein
TestosteroneMetabolite
cAMPMetabolite

Annotated Interactions

No annotated interactions

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