Platelet-mediated interactions with vascular and circulating cells (Homo sapiens)

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1MonocyteEndothelial cellPlateletDengue, flu, CMVInflammatory SignalsInfectionActivation, differentiationIgG productionFormation of Heterotypic Aggregates (HAGs)Granule contentreleaseDCs become antigen presenting cellsRecruitment of leukocytesIncreased endothelialpermeabilityIL1BTLR2SELEP-selectinCD40TLR4TLR7Dendritic cellCD40VCAM1ICAM1PF4SerotoninCCL5TGFB1B cellEosinophilCD40LGEndothelial cellNeutrophilT cellNK cellPSGL1P-selectinPSGL1PSGL1CD40-LTLR4IL1BCCL2TGFB2TGFB3


Description

This pathway describes platelet-mediated interactions with vascular or circulating cells. It is adapted from figure 2 in Koupenova et al, in collaboration with Dr. Milka Koupenova.

Platelets interact with endothelial and immune cells in the circulation, and control the response to microbes, inflammatory stimuli, and vessel damage. Through their TLRs or inflammatory signals, platelets can change their surface expression and release their granule content and in that way interact with different immune cells. Platelets form heterotypic aggregates with other immune cells and initiate innate immune responses in the presence of TLR agonists and viruses (encephalomyocarditis virus, coxsackievirus B, dengue, flu and HIV). Platelets can also interact with dendritic cells through P-selectin, and activate them to become antigen-presenting through their CD154. Platelets engage the adaptive immune response by releasing their granule content which leads to IgG production and control of T-cell function. Similarly, platelets are able to activate the endothelium, make it more permeable, and mediate leukocyte trafficking to the inflamed endothelium.

Description is adapted from Koupenova et al.

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Bibliography

  1. Koupenova M, Clancy L, Corkrey HA, Freedman JE; ''Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis.''; Circ Res, 2018 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
102079view19:26, 28 November 2018EgonwReplaced old Uniprot data sources with the new ones.
102059view21:41, 27 November 2018KhanspersModified description
102058view21:26, 27 November 2018Khanspersfinalized endothelial cell
102047view23:34, 26 November 2018Khanspersmoved PSGL1 to endothelial cell
102046view22:54, 26 November 2018Khanspersupdates based on feedback from original author
101971view14:01, 21 November 2018DeSlChanged secondary to primary ChEBI ID for serotonin.
101846view00:18, 13 November 2018KhanspersOntology Term : 'hemostasis pathway' added !
101845view00:18, 13 November 2018KhanspersOntology Term : 'platelet' added !
101844view00:18, 13 November 2018KhanspersOntology Term : 'thrombosis' added !
101843view00:17, 13 November 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCL2GeneProductENSG00000108691 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CD40-LProteinP29965 (Uniprot-TrEMBL)
CD40GeneProductENSG00000101017 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CD40ProteinP25942 (Uniprot-TrEMBL)
ICAM1GeneProductENSG00000090339 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
P-selectinProteinP16109 (Uniprot-TrEMBL)
PF4GeneProductENSG00000163737 (Ensembl)
PSGL1ProteinQ14242 (Uniprot-TrEMBL)
SELEGeneProductENSG00000007908 (Ensembl)
SerotoninMetaboliteCHEBI:28790 (ChEBI)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TLR2ProteinO60603 (Uniprot-TrEMBL)
TLR4ProteinO00206 (Uniprot-TrEMBL)
TLR7ProteinB2R9N9 (Uniprot-TrEMBL)
VCAM1GeneProductENSG00000162692 (Ensembl)

Annotated Interactions

No annotated interactions

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