MAPK Cascade (Rattus norvegicus)

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1, 2p38 MAPK PathwayGb and GgStress Activated PathwaysGiGrowth and MitogenesisActivatedRap1GAPComplexNucleusGqLOC100912399ArafMap3k3Elk1RapGAPIIMapk12RrasMap2k4Map2k1BrafNrasMap3k12Mapk10Mapk3Mapk14Map2Raf1Map2k4MbpMap2k6Plcb3HrasMapk1Map2k7Map2k3Map3k2KrasSipa1GDPJunApoptosisRasa3Map2k2GTP


Description

The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP422 (r95146) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC
  2. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95772view14:24, 19 January 2018MkutmonHomology conversion update
71797view20:33, 17 October 2013MaintBotAutomated update of data sources
71304view16:59, 17 October 2013MaintBotAutomated update of data sources
69419view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67439view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
62850view05:06, 3 May 2013MaintBotUpdated UniProt data source
41742view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
35462view11:54, 12 February 2010MichielAdded ref
34115view19:25, 9 December 2009MaintBotAutomatic update of empty xrefs
32434view17:14, 15 August 2009MaintBotFixed text labels
32103view13:46, 14 August 2009MaintBotFixed group labels
31455view21:12, 13 August 2009MaintBotFixed text labels
30956view00:44, 30 July 2009MaintBotConverted from Homo sapiens
21618view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:MAPK Cascade]] moved to [[Pathway:WP446]]: Moved to stable identifier
8246view13:46, 7 January 2008MaintBot[[Pathway:Rat:MAPK Cascade]] moved to [[Pathway:Rattus norvegicus:MAPK Cascade]]: Renaming species
7743view16:14, 18 December 2007MaintBotfixed category names
7276view12:41, 4 November 2007MaintBotAdded categories to GPML
19507view22:20, 22 May 2007I.Reyesgpml file for [[Rat:MAPK_Cascade]]
6573view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:MAPK_Cascade]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
ArafGeneProductENSRNOG00000010838 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:369
BrafGeneProductENSRNOG00000010957 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:673
Elk1GeneProductENSRNOG00000010171 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2002
GDPMetabolite146-91-8 (CAS)
GTPMetabolite2564-35-4 (CAS)
HrasGeneProductENSRNOG00000016611 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3265
JunGeneProductENSRNOG00000026293 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3725
KrasGeneProductENSRNOG00000009338 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3845
LOC100912399GeneProductENSRNOG00000013177 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4214
Map2GeneProductENSRNOG00000011841 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4133
Map2k1GeneProductENSRNOG00000010176 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5604
Map2k2GeneProductENSRNOG00000020005 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5605
Map2k3GeneProductENSRNOG00000049132 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5606
Map2k4GeneProductENSRNOG00000003834 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6416
Map2k6GeneProductENSRNOG00000004437 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5608
Map2k7GeneProductENSRNOG00000001047 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5609
Map3k12GeneProductENSRNOG00000015134 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7786
Map3k2GeneProductENSRNOG00000014089 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10746
Map3k3GeneProductENSRNOG00000061424 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4215
Mapk10GeneProductENSRNOG00000002079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5602
Mapk12GeneProductENSRNOG00000031233 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6300
Mapk14GeneProductENSRNOG00000000513 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1432
Mapk1GeneProductENSRNOG00000001849 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5594
Mapk3GeneProductENSRNOG00000053583 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5595
MbpGeneProductENSRNOG00000016516 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4155
NrasGeneProductENSRNOG00000023079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4893
Plcb3GeneProductENSRNOG00000021150 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5331
Raf1GeneProductENSRNOG00000010153 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5894
RapGAPIIGeneProduct
Rasa3GeneProductENSRNOG00000017671 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22821
RrasGeneProductENSRNOG00000037247 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6237
Sipa1GeneProductENSRNOG00000020726 (Ensembl)
  • not confirmed SwissProt ID - mu: SPA1 MOUSE
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6494

Annotated Interactions

No annotated interactions
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