Activation of kainate receptors upon glutamate binding (Homo sapiens)

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511412, 36cytosolCl- Cl- Cl- GNB4 GNGT1 GNB2 DLG4 GNB1 GNG8 Edited KainatereceptorsEdited GRIK2 (GluR6) GNB4 GRIK3 GNG13 PLCB3 PLCB1 GNGT2 GNB3 GNG12 GNB5 Ca2+GRIK2 GNGT1 Cl- GNG3 GNG7 L-Glu L-Glu GNG2 Edited GRIK 1 (GluR5) L-GluGRIK4 GRIK4 Kainate ReceptorsCl- L-Glu Edited GRIK2 (GluR6) GRIK 3 homomerGNG4 GNG8 Ca2+GNGT2 GNB1 PLCB3 GRIK3 GNB5 GNG5 GNG12 GRIK5 CALM1 DLG4 GRIK3 NCALD GRIK5 GNG2 GRIK3 homomerglutamate complexNa+DLG3 PLCB2 PLCB1 Cl- GNG4 Kainatereceptor-glutamate-Gprotein complexG-proteinbeta-gamma:PLC beta1/2/3GNB3 GRIK1 GNG13 DLG3 Edited GRIK 1 (GluR5) Na+GNG7 CALM1 Kainatereceptor-glutamatecomplexGNG10 Cl- GNG11 Edited KainateReceptor-glutamatecomplexNCALD GNG3 GRIK3 PLCB2 GRIK1 GNG11 GNG10 L-Glu DLG1 GRIK2 GRIK3 GNG5 GNB2 DLG1


Description

Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons.
Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons.
Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 451326
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Mahajan, SS

Quality Tags

Ontology Terms

 

Bibliography

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  1. Gill MB, Vivithanaporn P, Swanson GT.; ''Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.''; PubMed Europe PMC
  2. Bardoul M, Levallois C, König N.; ''Functional AMPA/kainate receptors in human embryonic and foetal central nervous system.''; PubMed Europe PMC
  3. Carver JM, Mansson PE, Cortes-Burgos L, Shu J, Zhou LM, Howe JR, Giordano T.; ''Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors.''; PubMed Europe PMC
  4. Perrais D, Coussen F, Mulle C.; ''Atypical functional properties of GluK3-containing kainate receptors.''; PubMed Europe PMC
  5. Jane DE, Lodge D, Collingridge GL.; ''Kainate receptors: pharmacology, function and therapeutic potential.''; PubMed Europe PMC
  6. Wilding TJ, Zhou Y, Huettner JE.; ''Q/R site editing controls kainate receptor inhibition by membrane fatty acids.''; PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
102017view15:16, 26 November 2018Marvin M2Ontology Term : 'neuron-to-neuron signaling pathway via the chemical synapse' added !
101670view13:49, 1 November 2018DeSlOntology Term : 'signaling pathway' added !
101669view13:49, 1 November 2018DeSlOntology Term : 'neuron' added !
101657view11:51, 1 November 2018ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CALM1 ProteinP0DP23 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl- MetaboliteCHEBI:17996 (ChEBI)
DLG1 ProteinQ12959 (Uniprot-TrEMBL)
DLG3 ProteinQ92796 (Uniprot-TrEMBL)
DLG4 ProteinP78352 (Uniprot-TrEMBL)
Edited GRIK 1 (GluR5) ProteinP39086 (Uniprot-TrEMBL) Glutamine at position 636 is replaced by arginine in an editing step which occurs posttranscriptionally.
Edited GRIK2 (GluR6) ProteinQ13002 (Uniprot-TrEMBL) GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.
Edited Kainate

Receptor-glutamate

complex
ComplexR-HSA-451304 (Reactome)
Edited Kainate receptorsComplexR-HSA-451279 (Reactome) Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.
G-protein

beta-gamma:PLC beta

1/2/3
ComplexR-HSA-398037 (Reactome)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GRIK 3 homomerComplexR-HSA-450196 (Reactome)
GRIK1 ProteinP39086 (Uniprot-TrEMBL)
GRIK2 ProteinQ13002 (Uniprot-TrEMBL)
GRIK3 ProteinQ13003 (Uniprot-TrEMBL)
GRIK3 homomer glutamate complexComplexR-HSA-500705 (Reactome)
GRIK4 ProteinQ16099 (Uniprot-TrEMBL)
GRIK5 ProteinQ16478 (Uniprot-TrEMBL)
Kainate

receptor-glutamate

complex
ComplexR-HSA-451281 (Reactome)
Kainate receptor-glutamate-Gprotein complexComplexR-HSA-500703 (Reactome)
Kainate ReceptorsComplexR-HSA-450885 (Reactome) Kainate receptors are formed by the assembly of four subunits. GluR5-7 (GRIK, glutamate receptor, ionotropic Kainate 1-3) form functional homomers whereas, KA1 and KA2 or GRIK4,5 form functional heteromers with GRIK1/2/3. Kainate receptor subunits bind Cl- ion in the anion binding site in the ligand binding domain. The dimer is stabilized by the presence of one Cl- ion which binds within the dimer interface.
L-Glu MetaboliteCHEBI:29985 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
NCALD ProteinP61601 (Uniprot-TrEMBL)
Na+MetaboliteCHEBI:29101 (ChEBI)
PLCB1 ProteinQ9NQ66 (Uniprot-TrEMBL)
PLCB2 ProteinQ00722 (Uniprot-TrEMBL)
PLCB3 ProteinQ01970 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
Ca2+ArrowR-HSA-451311 (Reactome)
Ca2+R-HSA-451311 (Reactome)
Edited Kainate

Receptor-glutamate

complex
ArrowR-HSA-451309 (Reactome)
Edited Kainate

Receptor-glutamate

complex
mim-catalysisR-HSA-451310 (Reactome)
Edited Kainate receptorsR-HSA-451309 (Reactome)
G-protein

beta-gamma:PLC beta

1/2/3
R-HSA-500717 (Reactome)
GRIK 3 homomerR-HSA-500708 (Reactome)
GRIK3 homomer glutamate complexArrowR-HSA-500708 (Reactome)
GRIK3 homomer glutamate complexR-HSA-500717 (Reactome)
GRIK3 homomer glutamate complexmim-catalysisR-HSA-500717 (Reactome)
Kainate

receptor-glutamate

complex
ArrowR-HSA-451283 (Reactome)
Kainate

receptor-glutamate

complex
mim-catalysisR-HSA-451311 (Reactome)
Kainate receptor-glutamate-Gprotein complexArrowR-HSA-500717 (Reactome)
Kainate ReceptorsR-HSA-451283 (Reactome)
L-GluR-HSA-451283 (Reactome)
L-GluR-HSA-451309 (Reactome)
L-GluR-HSA-500708 (Reactome)
Na+ArrowR-HSA-451310 (Reactome)
Na+R-HSA-451310 (Reactome)
R-HSA-451283 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-451309 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-451310 (Reactome) The activation of Kainate receptors by glutamate in the postsynaptic neuron leads to influx of Na+ ions resulting in depolarization of the postsynaptic membrane.
R-HSA-451311 (Reactome) Kainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.
These channels permit Ca2+ upon activation by glutamate or other agonists.
R-HSA-500708 (Reactome) Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
R-HSA-500717 (Reactome) Kainate receptor activation activates G protein coupled receptors involving the release of Ca2+ from the intracellular stores. This activity of Kainate receptors is independent of ionic influx and regulates both glutamate release by the pyramidal neurons and gama-aminobutyric acid release by the internuerons.
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