p75 NTR receptor-mediated signalling (Homo sapiens)

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1, 33, 3941, 482726234, 139, 3714438, 17161915, 35, 4258, 2434622407, 38, 472184710, 4220324728114732624168314247endosomenucleoplasmcytosolMCF2L ABR UBC(381-456) UbRHOA ARHGDIA NGFR RHOA:GDPNGFligand:p75NTR:IRAK1:MYD88K63polyUb-TRAF6 NGFR SQSTM1 UBC(153-228) GTP NGFR:RTN4RPRKCIARHGEF38 FGD2 ADPNGF(19-241) NGFR RPS27A(1-76) MAG KALRN NGFR RTN4 UBC(229-304) UBB(1-76) RHOA:GDP:ARHGDIAARHGEF35 NGFR p-S,T-IRAK1 ARHGEF5 ARHGEF37 UBC(229-304) MAPK8SQSTM1ARHGEF26 RTN4R multimer SQSTM1 SOS2 RTN4R multimerUBC(77-152) NGFligand:p75NTR:Phospho-IRAK1:TRAF6:p62UBC(305-380) UBC(77-152) PSEN1(299-467) UBC(229-304) NFKB1(1-433) p-S,T-IRAK1-1 SQSTM1 UBC(305-380) YWHAE PLEKHG5 APH1A RTN4 RELA LINGO1 UBB(153-228) MAG NGFR NGFRAP1 Active N-SMase:Mg2+NGF NGF NGF UBB(1-76) UbiquitinatedNRIF:Sequestosomep-S128-BADNFKB1(1-433) GTP UBC(77-152) MAG NFKB1(1-433) TIAM2 MYD88 dimerp75NTR:sortilincomplexARHGEF2 UBA52(1-76) NGFR RIPK2TRAF6 ARHGEF4 NFKB1(1-433) MAGED1NGFligand:p75NTR:NRIFUBC(533-608) pro-beta-NGFhomodimerARHGEF11 TRAF6 homotrimerGDP NGFligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6TRIO NGFR ARHGEF10L SORCS3(?-?) ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMGAKAP13 RELA UBC(77-152) UBC(457-532) NGF UBC(609-684) UBA52(1-76) UBA52(1-76) p-T,Y-MAPK8UBC(457-532) TIAM1 NGFR ATPPRDM4 IKBKB TRAF6 UBC(1-76) RASGRF2 GDP UBC(381-456) IKBKB dimerARHGDIA N-acylsphingosineNGF ITGB3BPNGFR UBC(1-76) ATPNGFR ATPPSENEN SOS1 Mg2+ UBC(229-304) UBC(305-380) LINGO1 NGFR:RTN4R:LINGO1Procaspases 2, 3ADPUBC(533-608) MYD88 NGFligand:p75NTR:NRAGE:CHE1UBC(609-684) ATPRTN4R multimer LINGO1 NGF NGFR Mg2+ NGF:p75NTR:NRAGEPSEN1(1-298) BCL2L11SQSTM1 UBC(381-456) TRAF6 TRAF6 SMPD2 UBB(153-228) NGFR MCF2NGFR RPS27A(1-76) mature NGFhomodimer:p75NTRUBB(77-152) p-S,T-IRAK1 FGD1 HDAC2 UBC(1-76) NGF MYD88 RPS27A(1-76) RHOA PSEN2(298-448) K63 linkedpolyubiquitin chainNGF NGEF RIPK2 NGFligand:p75NTR:Phospho-IRAK1:TRAF6HDAC1 NGFR(29-250)GDP SQSTM1 unknown kinaseCASP3(29-175) NGF SMPD2UBB(77-152) GNA13 NGFR(273-427)mature NGFhomodimer:p75NTRRELA Ubiquitinatedphospho-IkBUBB(153-228) ARHGEF3 UBC(609-684) RHOA NGFR(251-427)MAG NGFRRTN4R multimer UBA52(1-76) UBB(77-152) UBC(305-380) p-S32,S36-NFKBIA UBC(153-228) ADPSORCS3(?-?) UBC(533-608) p-S,T-IRAK1 NGF ARHGDIA NGFR PRDM4RTN4,MAG,OMGNFKB1(1-433):RELAGDP PREX1 ARHGEF7 p-S,T-IRAK1 NGFR NGF NGFR(251-427)NGFR NGFR H2OITGB3BP MYD88 NGFligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCiRPS27A(1-76) GTPUBC(1-76) TRAF6NGF:p75NTR:NADENGF(19-241) OMG ATPARHGEF16 UBB(77-152) Signaling by NTRK1(TRKA)p-S,T-IRAK1 ADPSPHMAATF NF-kB:p75NTRICD:TRAF6NGFRAP1 NGFR p-S32,S36-NFKBIANCSTN SQSTM1NGF PSEN1(299-467) RHOA:GTPUBC(305-380) RTN4 ARHGEF18 NGFR PSEN2(298-448) MAGED1 SQSTM1 CASP2(2-452) UBB(153-228) UbUBB(77-152) ChoPNGFR ARHGEF40 APH1B PLEKHG2 NGF processingPRDM4UBB(77-152) NGFligand:p75NTR:NADE:14-3-3epsilonUBC(153-228) UBB(153-228) UBC(381-456) UBC(153-228) GEFsUBC(381-456) UBC(457-532) UBC(381-456) CASP3(176-277) PSEN2(1-297) UBC(77-152) ARHGEF6 ARHGDIA NGFligand:p75NTR:NRIF:TRAF6ARHGEF17 APH1A OMG HDAC1 ARHGEF10 NFKB1(1-433):RELAUBB(153-228) VAV1 ADPUBC(533-608) GDPGTP SQSTM1 NGF UBB(1-76) GGC-PalmC-RAC1 RTN4 Ubiquitinated NRIFADPUBA52(1-76) NGFR HDAC2 ITGB3BP NGF PRDM4 UBC(305-380) NGF CASP3(1-277) ATPYWHAE IKBKB RAC1:GTPgamma-secretasecomplexRHOA ARHGEF39 UBC(153-228) PSENEN GDP UBC(1-76) TRAF6 RHOA p-S65-BCL2L11RELA NGF RPS27A(1-76) MAPK8NGF RAC1:GDPUBC(305-380) UBA52(1-76) NGFRNFKB1(1-433) mature beta-NGFhomodimerMCF2 ATPUBC(229-304) NFKBIA OMG GDP RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMGUBC(153-228) ARHGEF15 UBC(457-532) ARHGEF12 TRAF6mature NGFhomodimer:p75NTRIRAK1:MYD88IkB(alpha):NF-kBcomplexHistone deacetylaseFGD3 VAV2 ECT2 ITGB3BP NET1 OMG NGF:p75NTR:RIP2ARHGEF1 NCSTN APH1B p-S177,S181-IKBKB NGFR(273-427)UBC(609-684) gamma-secretasecomplexUBB(153-228) ARHGDIA NGFRNGF UBC(153-228) IRAK1 NGFligand:p75NTR:p-IRAK1:MYD88TRAF6 YWHAE dimerRTN4R multimer TRAF6 UBC(457-532) UBA52(1-76) VAV3 UBC(533-608) UBC(457-532) UBB(1-76) RHOA:GDP:ARHGDIA:NGFRARHGEF33 NGF:p75NTR:PRDM4NGFR UBB(1-76) NGFR UBC(609-684) p-S,T-IRAK1 UBC(609-684) PSEN2(1-297) CASP2(170-325) pro-betaNGF:p75NTR:sortilinHDAC3 HDAC3 RTN4R multimer PRDM4:HistonedeacetylaseUBC(77-152) NGFR NGFR:RTN4R:LINGO1:RTN4,MAG,OMGADAM 17metalloprotease (Zncofactor)UBC(381-456) UBC(229-304) UBB(77-152) ARHGEF9 NGFR(273-427) NGFligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62NFKB1(1-433):RELARPS27A(1-76) ITSN1 Active Caspases 2, 3NGFRAP1RELA Mg2+CASP2(348-452) UBC(77-152) UBB(1-76) p-S,T-IRAK1 NGF NGFR FGD4 IRAK1 ADAM17 ITGB3BP GGC-PalmC-RAC1 MAPK8UBC(533-608) p-T,Y-MAPK8NGF BADRHOA UBC(229-304) NGFR(251-272)MYD88 AATFNGF NGFR MAGED1 NGF UBB(1-76) ITGB3BP UBC(533-608) PSEN1(1-298) NGFR NGFligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-betaTRAF6 NGFligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-betaRPS27A(1-76) NGFR UBC(1-76) LINGO1ADPUBC(457-532) MYD88 UbiquitinatedNRIF:SequestosomeUBC(609-684) RHOA:GDP:ARHGDIA:NGFR:NGFTRAF6 ARHGEF19 LINGO1 OBSCN UBC(1-76) p-T,Y-MAPK8PRKCI p-T,Y-MAPK825, 30, 34, 4529, 36441812124436229, 36