Biosynthesis of DHA-derived SPMs (Homo sapiens)

From WikiPathways

Jump to: navigation, search
1, 15, 342343414, 3513, 17, 24, 28, 3110, 26, 303, 5, 213763311625, 368, 20, 2767610, 26, 3010, 26, 3032, 343425, 3615, 393410, 26, 302, 383418, 32, 343317, 28326, 244, 283422, 343318, 32, 3439342, 7, 9, 12, 23346, 2617, 19, 281134372, 7, 12342, 73, 5, 21, 34623366203334cytosolendoplasmic reticulum lumenProtectinsMaresin-like SPMsAT-(N)PD1 16S,17S-epoxy-DHAMaresinsresolvin D3 MaR-L2 LTA4H:Zn2+RvD3, RvD4LTC4S 7(S)-Hp-17(S)-HDHAresolvin D4 LTA4H CYP4RCTR1 Maresin-like SPMsaspirin-triggered resolvin D6 resolvin D4 PCTR2 RvD1 CYP2D6 RvD1, RvD2LTA4H:Zn2+resolvin D3 14(R),21(S/R)-diHDHA O2resolvin D6ALOX1514(S),21(S)-diHDHA reduced acceptor22-OH-(N)PD1 17(R)-Hp-DHA(N)PD1PDXMaR2GSTM4 dimerO27S(8)-epoxy-17(R)-HDHAO-acetyl-L-serine-PTGS2 HydroperoxyreductaseRvD1-6aspirin-triggered resolvin D3 PCTR3 ALOX5MCTR1ALOX12:Fe2+22-OH-(N)PD1CYP1A1, CYP1A2H2ONADP+H2OEPHX2 H+PCTR3ALOX154S(5)-epoxy-17(R)-HDHAreduced acceptorRvD1NADP+H2OO2CYP1A1 MaR2 H+PDX NAD+H2Oaspirin-triggered resolvin D2 MCTR1 17R(16)-epoxy-DHAaspirin-triggered resolvin D4 CYP2C9 NADPHH+AT-RvD5 RCTR2MCTR3MaR-L1 17(S)-Hp-DHAoxidised acceptorRCTR3ALOX12 PCTR1 resolvin D5 H2OAT-RvD6 CYP4O2RCTR1NADPHRvD1-6Fe2+ 7S(8)-epoxy-17(S)-HDHAZn2+ resolvin D5 NADP+Mg2+ GPX4-2O217(S)-HDHAZn2+ 14(S)-Hp-DHADHA14(R),21(S/R)-diHDHA CYP3A4 O2NADP+PCTR27(S)-Hp-17(R)-HDHA22-OH-(N)PD1 RCTR3 NADPH13(S),14(S)-epoxy-DHA(N)PD1 LTC4S trimerresolvin D4 NADPHMaR-L2ProtectinsMaR-L2 AT-RvD1, AT-RvD2HPGD CYP2C8 H2O14(R)-HDHAaspirin-triggered resolvin D4 AT-RvD1-6aspirin-triggered resolvin D2 NADPHaspirin-triggered resolvin D4 H+GGTH2ORCTR2 PCTR1GlyALOX5resolvin D6 H2OLTA4H Epoxide hydrolaseLTC4S trimer7-epi-MaR1GlyMCTR2AT-RvD5DPEPRvD2 PTGS2 GSSGaspirin-triggered resolvin D5 14(S),21(S/R)-diHDHA CYP2E1 HydroperoxyreductaseNADP+resolvin D57(S),17(S)-diHp-DHAGSH8-oxo-17(S)-RvD1 NADP+AT-RvD1 RvD1 LTC4S 7(S),14(S)-diHp-DHAMCTR2 resolvin D3 AT-RvD1 17(R)-HDHAMaR1 heme b aspirin-triggered resolvin D3 LTA4H:Zn2+L-GluNADHRvD2 CYP1A2 MaR1 AT-(N)PD1MaR2 14(S),21(R)-diHDHA MaresinsNADPHMaR-L1 MCTR2 O2PCTR2 EPHX2 dimerMCTR1 H2OH2O4(S)-Hp-17(S)-HDHA(N)PD1 PDX NADPHAc-PTGS2 dimerGSHoxidised acceptorALOX517(S)-oxo-RvD1,8-oxo-17(S)-RvD1H2Osulfido conjugatesNADPHH2OO2sulfido conjugates14(R),21(R)-diHDHA aspirin-triggered resolvin D3 CYP2E114(S),21(S/R)-diHDHA CYP1A2 7-epi-MaR1 14(S)-HDHARCTR3 AT-(N)PD1 CYP1A2,2C8,2C9,2D6,2E1,3A4HPGD dimerNADP+MaR1GSH14(R),21(S)-diHDHA RCTR1 AT-RvD1-6H2ORvD2 AT-RvD1 GGT7-epi-MaR1NADPHresolvin D6 Zn2+ PCTR3 7-epi-MaR1 LTA4H RCTR2 H2OH2O17(S)-oxo-RvD1 GSTM4 MaR-L1GSHMCTR3 ALOX5aspirin-triggered resolvin D2 4(S)-Hp-17(R)-HDHARvD1 O2AT-RvD6PCTR1 LipoxygenaseMCTR3 4S(5)-epoxy-17(S)-HDHAAT-RvD3, AT-RvD414(S),21(S/R)-diHDHAL-GluNADP+CYP2E1NADP+14(R),21(S/R)-diHDHA2916


Docosahexaenoic acid (DHA), a major ω-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of D-series resolvins (RvDs), one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017). The biosynthesis of RvDs occurs mainly during the process of inflammation when endothelial cells interact with leukocytes. Dietary DHA circulates in plasma or is present in cellular membranes as it can easily integrate into membranes. On injury or infection, DHA moves with edema into the tissue sites of acute inflammation where it is converted to exudate RvDs to interact with local immune cells (Kasuga et al. 2008). The initial transformation of DHA by aspirin-acetylated cyclooxygenase-2 or cyclooxygenase-mediated catalysis can produce stereospecific D-resolvins (18(R)- or 18(S)-RvDs respectively). Combinations of oxidation, reduction and hydrolysis reactions determine the type of D-resolvin formed (RvD1-6) (Serhan et al. 2002, Serhan & Petasis 2011, Serhan et al. 2014). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 9018677
Reactome version: 66
Reactome Author 
Reactome Author: Jassal, Bijay

Quality Tags

Ontology Terms



View all...
  1. Serhan CN, Petasis NA.; ''Resolvins and protectins in inflammation resolution.''; PubMed Europe PMC
  2. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M.; ''Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.''; PubMed Europe PMC
  3. Winkler JW, Orr SK, Dalli J, Cheng CY, Sanger JM, Chiang N, Petasis NA, Serhan CN.; ''Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance.''; PubMed Europe PMC
  4. Kim HY, Karanian JW, Salem N.; ''Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets.''; PubMed Europe PMC
  5. Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CN.; ''Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.''; PubMed Europe PMC
  6. Dalli J, Ramon S, Norris PC, Colas RA, Serhan CN.; ''Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways.''; PubMed Europe PMC
  7. Deng B, Wang CW, Arnardottir HH, Li Y, Cheng CY, Dalli J, Serhan CN.; ''Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.''; PubMed Europe PMC
  8. Tian H, Lu Y, Shah SP, Hong S.; ''14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds.''; PubMed Europe PMC
  9. Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA.; ''Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.''; PubMed Europe PMC
  10. Dalli J, Chiang N, Serhan CN.; ''Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection.''; PubMed Europe PMC
  11. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K.; ''Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.''; PubMed Europe PMC
  12. Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN.; ''The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.''; PubMed Europe PMC
  13. Aursnes M, Tungen JE, Colas RA, Vlasakov I, Dalli J, Serhan CN, Hansen TV.; ''Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages.''; PubMed Europe PMC
  14. Tungen JE, Aursnes M, Vik A, Ramon S, Colas RA, Dalli J, Serhan CN, Hansen TV.; ''Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1.''; PubMed Europe PMC
  15. Serhan CN, Chiang N, Dalli J, Levy BD.; ''Lipid mediators in the resolution of inflammation.''; PubMed Europe PMC
  16. Lecomte M, Laneuville O, Ji C, DeWitt DL, Smith WL.; ''Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.''; PubMed Europe PMC
  17. Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NA.; ''Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.''; PubMed Europe PMC
  18. Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN.; ''Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.''; PubMed Europe PMC
  19. Chen P, Fenet B, Michaud S, Tomczyk N, Véricel E, Lagarde M, Guichardant M.; ''Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation.''; PubMed Europe PMC
  20. Lu Y, Tian H, Hong S.; ''Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing.''; PubMed Europe PMC
  21. Primdahl KG, Tungen JE, De Souza PRS, Colas RA, Dalli J, Hansen TV, Vik A.; ''Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA.''; PubMed Europe PMC
  22. Ogawa N, Sugiyama T, Morita M, Suganuma Y, Kobayashi Y.; ''Total Synthesis of Resolvin D5.''; PubMed Europe PMC
  23. Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS.; ''The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells.''; PubMed Europe PMC
  24. Ramon S, Dalli J, Sanger JM, Winkler JW, Aursnes M, Tungen JE, Hansen TV, Serhan CN.; ''The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation.''; PubMed Europe PMC
  25. Han X, Fan Z, Yu Y, Liu S, Hao Y, Huo R, Wei J.; ''Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase.''; PubMed Europe PMC
  26. Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN.; ''Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.''; PubMed Europe PMC
  27. Tian H, Lu Y, Shah SP, Hong S.; ''Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions.''; PubMed Europe PMC
  28. Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN.; ''Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation.''; PubMed Europe PMC
  29. Dong L, Vecchio AJ, Sharma NP, Jurban BJ, Malkowski MG, Smith WL.; ''Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.''; PubMed Europe PMC
  30. Dalli J, Sanger JM, Rodriguez AR, Chiang N, Spur BW, Serhan CN.; ''Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3.''; PubMed Europe PMC
  31. Hong S, Lu Y, Yang R, Gotlinger KH, Petasis NA, Serhan CN.; ''Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms.''; PubMed Europe PMC
  32. Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN.; ''Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation.''; PubMed Europe PMC
  33. Hong S, Lu Y, Tian H, Alapure BV, Wang Q, Bunnell BA, Laborde JM.; ''Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages.''; PubMed Europe PMC
  34. Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac RL.; ''Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.''; PubMed Europe PMC
  35. Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Gálvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN, Nebert DW.; ''Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways.''; PubMed Europe PMC
  36. Yagi K, Komura S, Kojima H, Sun Q, Nagata N, Ohishi N, Nishikimi M.; ''Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury.''; PubMed Europe PMC
  37. Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA.; ''Novel proresolving aspirin-triggered DHA pathway.''; PubMed Europe PMC
  38. Bannenberg G, Serhan CN.; ''Specialized pro-resolving lipid mediators in the inflammatory response: An update.''; PubMed Europe PMC
  39. Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N.; ''Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome.''; PubMed Europe PMC


View all...
102031view16:18, 26 November 2018Marvin M2Ontology Term : 'PW:0000029' removed !
102030view16:18, 26 November 2018Marvin M2Ontology Term : 'unsaturated fatty acid biosynthetic pathway' added !
101695view14:29, 1 November 2018DeSlchanged weird symbols
101694view14:28, 1 November 2018DeSlOntology Term : 'fatty acid biosynthetic pathway' added !
101499view11:36, 1 November 2018ReactomeTeamreactome version 66
101036view21:17, 31 October 2018ReactomeTeamreactome version 65
100727view20:11, 31 October 2018ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
(N)PD1 MetaboliteCHEBI:138655 (ChEBI)
(N)PD1MetaboliteCHEBI:138655 (ChEBI)
13(S),14(S)-epoxy-DHAMetaboliteCHEBI:132228 (ChEBI)
14(R),21(R)-diHDHA MetaboliteCHEBI:137361 (ChEBI)
14(R),21(S)-diHDHA MetaboliteCHEBI:137368 (ChEBI)
14(R),21(S/R)-diHDHA R-ALL-9027324 (Reactome)
14(R),21(S/R)-diHDHA R-ALL-9031816 (Reactome)
14(R),21(S/R)-diHDHAComplexR-ALL-9027324 (Reactome)
14(R)-HDHAMetaboliteCHEBI:137346 (ChEBI)
14(S),21(R)-diHDHA MetaboliteCHEBI:137354 (ChEBI)
14(S),21(S)-diHDHA MetaboliteCHEBI:137360 (ChEBI)
14(S),21(S/R)-diHDHA R-ALL-9027326 (Reactome)
14(S),21(S/R)-diHDHA R-ALL-9031811 (Reactome)
14(S),21(S/R)-diHDHAComplexR-ALL-9027326 (Reactome)
14(S)-HDHAMetaboliteCHEBI:137347 (ChEBI)
14(S)-Hp-DHAMetaboliteCHEBI:140220 (ChEBI)
16S,17S-epoxy-DHAMetaboliteCHEBI:140225 (ChEBI)
17(R)-HDHAMetaboliteCHEBI:91137 (ChEBI)
17(R)-Hp-DHAMetaboliteCHEBI:138590 (ChEBI)
17(S)-HDHAMetaboliteCHEBI:138640 (ChEBI)
17(S)-Hp-DHAMetaboliteCHEBI:136113 (ChEBI)
17(S)-oxo-RvD1 MetaboliteCHEBI:132800 (ChEBI)
17(S)-oxo-RvD1, 8-oxo-17(S)-RvD1ComplexR-ALL-9024799 (Reactome)
17R(16)-epoxy-DHAMetaboliteCHEBI:140192 (ChEBI)
22-OH-(N)PD1 MetaboliteCHEBI:140243 (ChEBI)
22-OH-(N)PD1MetaboliteCHEBI:140243 (ChEBI)
4(S)-Hp-17(R)-HDHAMetaboliteCHEBI:138601 (ChEBI)
4(S)-Hp-17(S)-HDHAMetaboliteCHEBI:138641 (ChEBI)
4S(5)-epoxy-17(R)-HDHAMetaboliteCHEBI:138612 (ChEBI)
4S(5)-epoxy-17(S)-HDHAMetaboliteCHEBI:138647 (ChEBI)
7(S),14(S)-diHp-DHAMetaboliteCHEBI:140196 (ChEBI)
7(S),17(S)-diHp-DHAMetaboliteCHEBI:140245 (ChEBI)
7(S)-Hp-17(R)-HDHAMetaboliteCHEBI:138602 (ChEBI)
7(S)-Hp-17(S)-HDHAMetaboliteCHEBI:138642 (ChEBI)
7-epi-MaR1 MetaboliteCHEBI:140193 (ChEBI)
7-epi-MaR1MetaboliteCHEBI:140193 (ChEBI)
7S(8)-epoxy-17(R)-HDHAMetaboliteCHEBI:138613 (ChEBI)
7S(8)-epoxy-17(S)-HDHAMetaboliteCHEBI:138646 (ChEBI)
8-oxo-17(S)-RvD1 MetaboliteCHEBI:132797 (ChEBI)
ALOX12 ProteinP18054 (Uniprot-TrEMBL)
ALOX12:Fe2+ComplexR-HSA-2142793 (Reactome)
ALOX15ProteinP16050 (Uniprot-TrEMBL)
ALOX5ProteinP09917 (Uniprot-TrEMBL)
AT-(N)PD1 MetaboliteCHEBI:140202 (ChEBI)
AT-(N)PD1MetaboliteCHEBI:140202 (ChEBI)
AT-RvD1 MetaboliteCHEBI:138179 (ChEBI)
AT-RvD1, AT-RvD2ComplexR-ALL-9024574 (Reactome)
AT-RvD1-6ComplexR-ALL-9024575 (Reactome)
AT-RvD1-6ComplexR-ALL-9024582 (Reactome)
AT-RvD3, AT-RvD4ComplexR-ALL-9024570 (Reactome)
AT-RvD5 MetaboliteCHEBI:138617 (ChEBI)
AT-RvD5MetaboliteCHEBI:138617 (ChEBI)
AT-RvD6 MetaboliteCHEBI:138618 (ChEBI)
AT-RvD6MetaboliteCHEBI:138618 (ChEBI)
Ac-PTGS2 dimerComplexR-HSA-2314687 (Reactome)
CYP1A1 ProteinP04798 (Uniprot-TrEMBL)
CYP1A1, CYP1A2ComplexR-HSA-9037759 (Reactome)
CYP1A2 ProteinP05177 (Uniprot-TrEMBL)
CYP1A2,2C8,2C9,2D6,2E1,3A4ComplexR-HSA-9027041 (Reactome)
CYP2C8 ProteinP10632 (Uniprot-TrEMBL)
CYP2C9 ProteinP11712 (Uniprot-TrEMBL)
CYP2D6 ProteinP10635 (Uniprot-TrEMBL)
CYP2E1 ProteinP05181 (Uniprot-TrEMBL)
CYP2E1ProteinP05181 (Uniprot-TrEMBL)
CYP3A4 ProteinP08684 (Uniprot-TrEMBL)
CYP4R-HSA-8957350 (Reactome)
DHAMetaboliteCHEBI:28125 (ChEBI)
DPEPR-HSA-2161751 (Reactome)
EPHX2 ProteinP34913 (Uniprot-TrEMBL)
EPHX2 dimerComplexR-HSA-2142777 (Reactome)
Epoxide hydrolaseR-HSA-9025025 (Reactome)
Fe2+ MetaboliteCHEBI:18248 (ChEBI)
GGTR-HSA-2161915 (Reactome)
GPX4-2ProteinP36969-2 (Uniprot-TrEMBL)
GSHMetaboliteCHEBI:16856 (ChEBI)
GSSGMetaboliteCHEBI:17858 (ChEBI)
GSTM4 ProteinQ03013 (Uniprot-TrEMBL)
GSTM4 dimerComplexR-HSA-3301926 (Reactome)
GlyMetaboliteCHEBI:57305 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HPGD ProteinP15428 (Uniprot-TrEMBL)
HPGD dimerComplexR-HSA-2142778 (Reactome)
Hydroperoxy reductaseR-HSA-9024779 (Reactome)
L-GluMetaboliteCHEBI:29985 (ChEBI)
LTA4H ProteinP09960 (Uniprot-TrEMBL)
LTA4H:Zn2+ComplexR-HSA-266038 (Reactome)
LTC4S ProteinQ16873 (Uniprot-TrEMBL)
LTC4S trimerComplexR-HSA-2142762 (Reactome)
LipoxygenaseR-HSA-9026899 (Reactome)
MCTR1 MetaboliteCHEBI:138202 (ChEBI)
MCTR1MetaboliteCHEBI:138202 (ChEBI)
MCTR2 MetaboliteCHEBI:138206 (ChEBI)
MCTR2MetaboliteCHEBI:138206 (ChEBI)
MCTR3 MetaboliteCHEBI:138209 (ChEBI)
MCTR3MetaboliteCHEBI:138209 (ChEBI)
MaR-L1 MetaboliteCHEBI:137349 (ChEBI)
MaR-L1MetaboliteCHEBI:137349 (ChEBI)
MaR-L2 MetaboliteCHEBI:137350 (ChEBI)
MaR-L2MetaboliteCHEBI:137350 (ChEBI)
MaR1 MetaboliteCHEBI:138249 (ChEBI)
MaR1MetaboliteCHEBI:138249 (ChEBI)
MaR2 MetaboliteCHEBI:138248 (ChEBI)
MaR2MetaboliteCHEBI:138248 (ChEBI)
Maresin-like SPMsComplexR-ALL-9031800 (Reactome)
Maresin-like SPMsComplexR-ALL-9031809 (Reactome)
MaresinsComplexR-ALL-9031813 (Reactome)
MaresinsComplexR-ALL-9031815 (Reactome)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
O-acetyl-L-serine-PTGS2 ProteinP35354 (Uniprot-TrEMBL)
O2MetaboliteCHEBI:15379 (ChEBI)
PCTR1 MetaboliteCHEBI:140262 (ChEBI)
PCTR1MetaboliteCHEBI:140262 (ChEBI)
PCTR2 MetaboliteCHEBI:140263 (ChEBI)
PCTR2MetaboliteCHEBI:140263 (ChEBI)
PCTR3 MetaboliteCHEBI:140264 (ChEBI)
PCTR3MetaboliteCHEBI:140264 (ChEBI)
PDX MetaboliteCHEBI:138653 (ChEBI)
PDXMetaboliteCHEBI:138653 (ChEBI)
PTGS2 ProteinP35354 (Uniprot-TrEMBL)
ProtectinsComplexR-ALL-9031812 (Reactome)
ProtectinsComplexR-ALL-9031819 (Reactome)
RCTR1 MetaboliteCHEBI:140268 (ChEBI)
RCTR1MetaboliteCHEBI:140268 (ChEBI)
RCTR2 MetaboliteCHEBI:140269 (ChEBI)
RCTR2MetaboliteCHEBI:140269 (ChEBI)
RCTR3 MetaboliteCHEBI:140270 (ChEBI)
RCTR3MetaboliteCHEBI:140270 (ChEBI)
RvD1 MetaboliteCHEBI:81564 (ChEBI)
RvD1, RvD2ComplexR-ALL-9024759 (Reactome)
RvD1-6ComplexR-ALL-9024812 (Reactome)
RvD1-6ComplexR-ALL-9024814 (Reactome)
RvD1MetaboliteCHEBI:81564 (ChEBI)
RvD2 MetaboliteCHEBI:81565 (ChEBI)
RvD3, RvD4ComplexR-ALL-9024809 (Reactome)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
aspirin-triggered resolvin D2 MetaboliteCHEBI:138614 (ChEBI)
aspirin-triggered resolvin D3 MetaboliteCHEBI:138615 (ChEBI)
aspirin-triggered resolvin D4 MetaboliteCHEBI:138616 (ChEBI)
aspirin-triggered resolvin D5 MetaboliteCHEBI:138617 (ChEBI)
aspirin-triggered resolvin D6 MetaboliteCHEBI:138618 (ChEBI)
heme b MetaboliteCHEBI:26355 (ChEBI)
oxidised acceptorR-ALL-9024637 (Reactome)
reduced acceptorR-ALL-5359016 (Reactome)
resolvin D3 MetaboliteCHEBI:138648 (ChEBI)
resolvin D4 MetaboliteCHEBI:138649 (ChEBI)
resolvin D5 MetaboliteCHEBI:138645 (ChEBI)
resolvin D5MetaboliteCHEBI:138645 (ChEBI)
resolvin D6 MetaboliteCHEBI:138643 (ChEBI)
resolvin D6MetaboliteCHEBI:138643 (ChEBI)
sulfido conjugatesComplexR-ALL-9031853 (Reactome)
sulfido conjugatesComplexR-ALL-9031855 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
(N)PD1ArrowR-HSA-9024890 (Reactome)
(N)PD1R-HSA-9037761 (Reactome)
13(S),14(S)-epoxy-DHAArrowR-HSA-9024983 (Reactome)
13(S),14(S)-epoxy-DHAR-HSA-9024973 (Reactome)
13(S),14(S)-epoxy-DHAR-HSA-9024993 (Reactome)
13(S),14(S)-epoxy-DHAR-HSA-9026544 (Reactome)
13(S),14(S)-epoxy-DHAR-HSA-9026777 (Reactome)
13(S),14(S)-epoxy-DHAR-HSA-9026780 (Reactome)
14(R),21(S/R)-diHDHAArrowR-HSA-9027321 (Reactome)
14(R)-HDHAArrowR-HSA-9027043 (Reactome)
14(R)-HDHAR-HSA-9027044 (Reactome)
14(R)-HDHAR-HSA-9027321 (Reactome)
14(S),21(S/R)-diHDHAArrowR-HSA-9027302 (Reactome)
14(S)-HDHAArrowR-HSA-9027033 (Reactome)
14(S)-HDHAR-HSA-9027042 (Reactome)
14(S)-HDHAR-HSA-9027302 (Reactome)
14(S)-Hp-DHAArrowR-HSA-9020274 (Reactome)
14(S)-Hp-DHAR-HSA-9024983 (Reactome)
14(S)-Hp-DHAR-HSA-9024997 (Reactome)
14(S)-Hp-DHAR-HSA-9027033 (Reactome)
16S,17S-epoxy-DHAArrowR-HSA-9024881 (Reactome)
16S,17S-epoxy-DHAR-HSA-9024890 (Reactome)
16S,17S-epoxy-DHAR-HSA-9026901 (Reactome)
17(R)-HDHAArrowR-HSA-9020271 (Reactome)
17(R)-HDHAR-HSA-9020251 (Reactome)
17(R)-HDHAR-HSA-9020259 (Reactome)
17(R)-Hp-DHAArrowR-HSA-9020261 (Reactome)
17(R)-Hp-DHAR-HSA-9020262 (Reactome)
17(R)-Hp-DHAR-HSA-9020271 (Reactome)
17(S)-HDHAArrowR-HSA-9020273 (Reactome)
17(S)-HDHAR-HSA-9020264 (Reactome)
17(S)-HDHAR-HSA-9020282 (Reactome)
17(S)-Hp-DHAArrowR-HSA-9020275 (Reactome)
17(S)-Hp-DHAR-HSA-9020273 (Reactome)
17(S)-Hp-DHAR-HSA-9024872 (Reactome)
17(S)-Hp-DHAR-HSA-9024881 (Reactome)
17(S)-Hp-DHAR-HSA-9026918 (Reactome)
17(S)-oxo-RvD1, 8-oxo-17(S)-RvD1ArrowR-HSA-9024766 (Reactome)
17R(16)-epoxy-DHAArrowR-HSA-9020262 (Reactome)
17R(16)-epoxy-DHAR-HSA-9020257 (Reactome)
22-OH-(N)PD1ArrowR-HSA-9037761 (Reactome)
4(S)-Hp-17(R)-HDHAArrowR-HSA-9020259 (Reactome)
4(S)-Hp-17(R)-HDHAR-HSA-9020278 (Reactome)
4(S)-Hp-17(R)-HDHAR-HSA-9024624 (Reactome)
4(S)-Hp-17(S)-HDHAArrowR-HSA-9020264 (Reactome)
4(S)-Hp-17(S)-HDHAR-HSA-9020249 (Reactome)
4(S)-Hp-17(S)-HDHAR-HSA-9020277 (Reactome)
4S(5)-epoxy-17(R)-HDHAArrowR-HSA-9020278 (Reactome)
4S(5)-epoxy-17(R)-HDHAR-HSA-9020270 (Reactome)
4S(5)-epoxy-17(S)-HDHAArrowR-HSA-9020277 (Reactome)
4S(5)-epoxy-17(S)-HDHAR-HSA-9020253 (Reactome)
7(S),14(S)-diHp-DHAArrowR-HSA-9024997 (Reactome)
7(S),14(S)-diHp-DHAR-HSA-9025007 (Reactome)