Signaling by PTK6 (Homo sapiens)

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1, 6, 9, 12, 15...69563, 145, 15622, 10114054, 122, 1319582952340, 117105, 164823527, 10033231141142210027, 10010210512282825451, 67, 11418, 70, 92, 9984, 103, 121709546, 776346, 1451176383, 10411484, 1213561011019510254104114cytosolnucleoplasmHBEGF:EGFR:p-Y525-GPNMBp-Y342-PTK6 UBC(381-456) ADPADPp-Y31,Y118-PXNHRAS Signaling by EGFRPTPN1 ADPRegulation ofHypoxia-inducibleFactor (HIF) byoxygenp-Y342-PTK6:ARHGAP35DOCK1 CDK4 ADPCDKN1B:(CDK4:CCND1,(CDK2:CCNE1))p-Y525-GPNMB ATPATPCCNE1 p-Y435,Y440,Y443-KHDRBS1p-Y342-PTK6:AKT1PTK6 GeneARAP1 p-Y342-PTK6RHOA UBB(1-76) p-Y165,Y664-BCAR1p-Y342-PTK6 p-Y705-STAT3 ARHGAP35 p-Y231-ARAP1HIF1A,EPAS1:PTK6Genep-Y342-PTK6 ADPLRRK2p-Y342-PTK6 KRAS HBEGF(63-148) p-Y342-PTK6 GTP KRAS SOCS3 GeneHBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2RHO GTPases activateCITp-Y342-PTK6 Phosphorylated p-Y877-ERBB2 heterodimers PTK6 Gene EPAS1 KHDRBS2p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))ELMO2 CBLp-Y1105-ARHGAP35RPS27A(1-76) BCAR1NRAS p-Y525-GPNMB SOCS3LINC01139GDPp-Y362-DOK1RASA1 ATPRHO GTPases activateIQGAPsPTK6 Gene p-Y342-PTK6 H2Op-Y342-PTK6:p-Y250-STAP2p-Y342-PTK6 STAP2p-Y1105-ARHGAP35:RHOA:GTPp-Y1105-ARHGAP35:RASA1BCAR1 p-Y342-PTK6:BCAR1PELP1RHO GTPases ActivateWASPs and WAVEsp-Y88-CDKN1B DOK1UBC(1-76) SemaphorininteractionsADPCCND1 HBEGF(63-148) GPNMBGDP UBA52(1-76) p-Y342-PTK6 HBEGF(63-148) RHOA LRRK2 p-Y342-PTK6DOK1 RHO GTPases activateKTN1UBB(153-228) AKT1EGFR p-Y705-STAT3ADPGDP NRAS HBEGF:EGFR:GPNMBHBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2p-Y351-PTK6 NR3C1:DexamethasonePXNPTK6Gene:EPAS1:NR3C1:Dexamethasone:PELP1p-Y705-STAT3dimer:SOCS3 GeneATPSOCS3 GTP KHDRSB3p-Y705-STAT3 CCND1 p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))PIP3 activates AKTsignalingKRAS Phosphorylated p-Y877-ERBB2 heterodimers p-Y342-PTK6:PTPN1PiATPADPDEXA UBB(77-152) PolyUb,p-Y700,Y731,Y774-CBLELMO1 PELP1 p-Y565,S797-HIF1ADEXA NR3C1 ADPCDK2 p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2RAF/MAP kinasecascadep-Y435,Y440,Y443-KHDRBS1CDK2 CRK LRRK2 ATPCRK EPAS1 PTK6p-Y342-PTK6 RAC1:GTPp-Y342-PTK6:SOCS3ADPp-Y342-PTK6:PXNPhosphorylated p-6Y-ERBB2 heterodimers UBC(609-684) RHOA:GTPHBEGF:EGFRNR3C1 p-Y250-STAP2 ATPPTK6 NRAS EGFR ATPHIF1A,EPAS1p-Y342,Y447-PTK6p-Y342-PTK6:KHDRBS1PiRHO GTPases activatePKNsADPATPLINC01139 p-Y-KHDRBS2p21 RAS:GTPATPHBEGF(63-148) GTP LINC01139 ATPUbUBC(229-304) KHDRBS1 HRAS p-Y342-PTK6 UBC(533-608) RHO GTPases activatePAKsCCNE1 p-Y250-STAP2 RASA1UBC(153-228) p-Y-SFPQp-Y700,Y731,Y774-CBLEGFR SFPQCDKN1B p-Y-KHDRSB3CDKN1B Signaling by ERBB2EPAS1 ADPp-Y342-PTK6:p-Y250-STAP2:STAT3GTP CDK4 RAC1 ADPGTP p-Y342-PTK6 EGFR RAC1 p21 RAS:GTP:RASA1CDK4 p-Y1105-ARHGAP35 EGFR p21 RAS:GDPKHDRBS1S Phasep-Y1105-ARHGAP35 p-ERBB2heterodimers:PTK6p-Y525-GPNMB PTK6 CRK:DOCK180:ELMO1,ELMO2HIF1AAKT1 RHOA p-Y31,Y118-PXN Phosphorylated p-6Y-ERBB2 heterodimers p-Y315,Y326-AKT1 DOCK1 EPAS1ATPELMO1 CCNE1 CDK2 ATPUBC(457-532) CCND1 PTPN1HRAS ARAP1RHO GTPases ActivateForminsATPp-Y705-STAT3 dimerUBC(77-152) p-ERBB2 heterodimersADPUBC(305-380) RASA1 p-Y342-PTK6 p-Y705-STAT3 dimerSTAT3 SRMSADPSOCS3 Gene p-Y342-PTK6:p-Y315,Y326-AKT1STAT3ELMO2 STAP2 p-Y342-PTK6 GDP RHOA:GDPp-Y342-PTK6:ARAP1GPNMB ATPp-Y705-STAT3 Mitotic G1-G1/SphasesHBEGF(63-148) GTPp-Y342-PTK6:STAP2HIF1A p-Y342-PTK6:DOK1HIF1A RAC1:GDPARHGAP35PXN 17, 52, 69, 94, 108...3, 7, 20, 30, 38...821145, 10, 16, 26, 42...667, 114952, 37, 57, 62, 68...951006363, 15613, 24, 32, 55, 59...95105, 16461, 88, 119, 15111, 34, 91, 96, 107...1022228, 4910154278210514, 25, 39, 44, 113...4, 8, 19, 29, 41...351142231, 43, 79, 143, 15384869511777


PTK6 (BRK) is an oncogenic non-receptor tyrosine kinase that functions downstream of ERBB2 (HER2) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). Since ERBB2 forms heterodimers with EGFR and since MET can heterodimerize with both ERBB2 and EGFR (Tanizaki et al. 2011), it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2. Levels of PTK6 increase under hypoxic conditions (Regan Anderson et al. 2013, Pires et al. 2014). The kinase activity of PTK6 is negatively regulated by PTPN1 phosphatase (Fan et al. 2013) and SRMS kinase (Fan et al. 2015), as well as the STAT3 target SOCS3 (Gao et al. 2012).

PTK6 activates STAT3-mediated transcription (Ikeda et al. 2009, Ikeda et al. 2010) and may also activate STAT5-mediated transcription (Ikeda et al. 2011). PTK6 promotes cell motility and migration by regulating the activity of RHO GTPases RAC1 (Chen et al. 2004) and RHOA (Shen et al. 2008), and possibly by affecting motility-related kinesins (Lukong and Richard 2008). PTK6 crosstalks with AKT1 (Zhang et al. 2005, Zheng et al. 2010) and RAS signaling cascades (Shen et al. 2008, Ono et al. 2014) and may be involved in MAPK7 (ERK5) activation (Ostrander et al. 2007, Zheng et al. 2012). PTK6 enhances EGFR signaling by inhibiting EGFR down-regulation (Kang et al. 2010, Li et al. 2012, Kang and Lee 2013). PTK6 may also enhance signaling by IGF1R (Fan et al. 2013) and ERBB3 (Kamalati et al. 2000).<p>PTK6 promotes cell cycle progression by phosphorylating and inactivating CDK inhibitor CDKN1B (p27) (Patel et al. 2015).<p>PTK6 activity is upregulated in osteopontin (OPN or SPP1)-mediated signaling, leading to increased VEGF expression via PTK6/NF-kappaB/ATF4 signaling path. PTK6 may therefore play a role in VEGF-dependent tumor angiogenesis (Chakraborty et al. 2008).<p>PTK6 binds and phosphorylates several nuclear RNA-binding proteins, including SAM68 family members (KHDRSB1, KHDRSB2 and KHDRSB3) (Derry et al. 2000, Haegebarth et al. 2004, Lukong et al. 2005) and SFPQ (PSF) (Lukong et al. 2009). The biological role of PTK6 in RNA processing is not known.<p>For a review of PTK6 function, please refer to Goel and Lukong 2015. View original pathway at:Reactome.</div>


Pathway is converted from Reactome ID: 8848021
Reactome version: 66
Reactome Author 
Reactome Author: Orlic-Milacic, Marija

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  1. Peng M, Ball-Kell SM, Tyner AL.; ''Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.''; PubMed Europe PMC
  2. Cantwell-Dorris ER, O'Leary JJ, Sheils OM.; ''BRAFV600E: implications for carcinogenesis and molecular therapy.''; PubMed Europe PMC
  3. Manser E, Chong C, Zhao ZS, Leung T, Michael G, Hall C, Lim L.; ''Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family.''; PubMed Europe PMC
  4. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR.; ''The E2F transcription factor is a cellular target for the RB protein.''; PubMed Europe PMC
  5. Kovar DR, Harris ES, Mahaffy R, Higgs HN, Pollard TD.; ''Control of the assembly of ATP- and ADP-actin by formins and profilin.''; PubMed Europe PMC
  6. Kang SA, Lee ES, Yoon HY, Randazzo PA, Lee ST.; ''PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.''; PubMed Europe PMC
  7. Chong C, Tan L, Lim L, Manser E.; ''The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.''; PubMed Europe PMC
  8. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D.; ''The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.''; PubMed Europe PMC
  9. Castro NE, Lange CA.; ''Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.''; PubMed Europe PMC
  10. Habas R, Kato Y, He X.; ''Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.''; PubMed Europe PMC
  11. Camera P, da Silva JS, Griffiths G, Giuffrida MG, Ferrara L, Schubert V, Imarisio S, Silengo L, Dotti CG, Di Cunto F.; ''Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.''; PubMed Europe PMC
  12. Kamalati T, Jolin HE, Mitchell PJ, Barker KT, Jackson LE, Dean CJ, Page MJ, Gusterson BA, Crompton MR.; ''Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor.''; PubMed Europe PMC
  13. Palmer RH, Dekker LV, Woscholski R, Le Good JA, Gigg R, Parker PJ.; ''Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes.''; PubMed Europe PMC
  14. Wang S, Watanabe T, Noritake J, Fukata M, Yoshimura T, Itoh N, Harada T, Nakagawa M, Matsuura Y, Arimura N, Kaibuchi K.; ''IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.''; PubMed Europe PMC
  15. Chakraborty G, Jain S, Kundu GC.; ''Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms.''; PubMed Europe PMC
  16. Miralles F, Posern G, Zaromytidou AI, Treisman R.; ''Actin dynamics control SRF activity by regulation of its coactivator MAL.''; PubMed Europe PMC
  17. Brahimi-Horn MC, Pouysségur J.; ''HIF at a glance.''; PubMed Europe PMC
  18. Ahmadian MR, Kiel C, Stege P, Scheffzek K.; ''Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.''; PubMed Europe PMC
  19. Chittenden T, Livingston DM, Kaelin WG.; ''The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.''; PubMed Europe PMC
  20. Chan PM, Manser E.; ''PAKs in human disease.''; PubMed Europe PMC
  21. Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z.; ''Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.''; PubMed Europe PMC
  22. Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner AL, Wagner R, Blain SW.; ''Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4.''; PubMed Europe PMC
  23. Haegebarth A, Heap D, Bie W, Derry JJ, Richard S, Tyner AL.; ''The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.''; PubMed Europe PMC
  24. Torbett NE, Casamassima A, Parker PJ.; ''Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.''; PubMed Europe PMC
  25. Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ.; ''The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.''; PubMed Europe PMC
  26. Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S.; ''Cdc42 and mDia3 regulate microtubule attachment to kinetochores.''; PubMed Europe PMC
  27. Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA.; ''Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.''; PubMed Europe PMC
  28. Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P.; ''Kinectin is a key effector of RhoG microtubule-dependent cellular activity.''; PubMed Europe PMC
  29. Hannon GJ, Beach D.; ''p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.''; PubMed Europe PMC
  30. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L.; ''A brain serine/threonine protein kinase activated by Cdc42 and Rac1.''; PubMed Europe PMC
  31. Dickson BJ.; ''Molecular mechanisms of axon guidance.''; PubMed Europe PMC
  32. Modha R, Campbell LJ, Nietlispach D, Buhecha HR, Owen D, Mott HR.; ''The Rac1 polybasic region is required for interaction with its effector PRK1.''; PubMed Europe PMC
  33. Lukong KE, Huot ME, Richard S.; ''BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.''; PubMed Europe PMC
  34. Bassi ZI, Audusseau M, Riparbelli MG, Callaini G, D'Avino PP.; ''Citron kinase controls a molecular network required for midbody formation in cytokinesis.''; PubMed Europe PMC
  35. Fan G, Lin G, Lucito R, Tonks NK.; ''Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.''; PubMed Europe PMC
  36. Kamalati T, Jolin HE, Fry MJ, Crompton MR.; ''Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation.''; PubMed Europe PMC
  37. Wellbrock C, Karasarides M, Marais R.; ''The RAF proteins take centre stage.''; PubMed Europe PMC
  38. Wang J, Wu JW, Wang ZX.; ''Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification.''; PubMed Europe PMC
  39. Fukata M, Kuroda S, Fujii K, Nakamura T, Shoji I, Matsuura Y, Okawa K, Iwamatsu A, Kikuchi A, Kaibuchi K.; ''Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42.''; PubMed Europe PMC
  40. Chastkofsky MI, Bie W, Ball-Kell SM, He YY, Tyner AL.; ''Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.''; PubMed Europe PMC
  41. Connell-Crowley L, Harper JW, Goodrich DW.; ''Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.''; PubMed Europe PMC
  42. Lammers M, Rose R, Scrima A, Wittinghofer A.; ''The regulation of mDia1 by autoinhibition and its release by Rho*GTP.''; PubMed Europe PMC
  43. Pasterkamp RJ, Kolodkin AL.; ''Semaphorin junction: making tracks toward neural connectivity.''; PubMed Europe PMC
  44. Pelikan-Conchaudron A, Le Clainche C, Didry D, Carlier MF.; ''The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration.''; PubMed Europe PMC
  45. Wallar BJ, Deward AD, Resau JH, Alberts AS.; ''RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking.''; PubMed Europe PMC
  46. Liu L, Gao Y, Qiu H, Miller WT, Poli V, Reich NC.; ''Identification of STAT3 as a specific substrate of breast tumor kinase.''; PubMed Europe PMC
  47. Ono H, Basson MD, Ito H.; ''PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.''; PubMed Europe PMC
  48. Serrano M, Hannon GJ, Beach D.; ''A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.''; PubMed Europe PMC
  49. Hotta K, Tanaka K, Mino A, Kohno H, Takai Y.; ''Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor.''; PubMed Europe PMC
  50. Parry D, Bates S, Mann DJ, Peters G.; ''Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.''; PubMed Europe PMC
  51. Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D.; ''Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.''; PubMed Europe PMC
  52. Majmundar AJ, Wong WJ, Simon MC.; ''Hypoxia-inducible factors and the response to hypoxic stress.''; PubMed Europe PMC
  53. Bione S, Sala C, Manzini C, Arrigo G, Zuffardi O, Banfi S, Borsani G, Jonveaux P, Philippe C, Zuccotti M, Ballabio A, Toniolo D.; ''A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility.''; PubMed Europe PMC
  54. Derry JJ, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V, Cochrane AW, Chen T, Tyner AL.; ''Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.''; PubMed Europe PMC
  55. Flynn P, Mellor H, Casamassima A, Parker PJ.; ''Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.''; PubMed Europe PMC
  56. Szczepanowska J.; ''Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.''; PubMed Europe PMC
  57. Cargnello M, Roux PP.; ''Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.''; PubMed Europe PMC
  58. Colón-Franco JM, Gomez TS, Billadeau DD.; ''Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex.''; PubMed Europe PMC
  59. Collazos A, Michael N, Whelan RD, Kelly G, Mellor H, Pang LC, Totty N, Parker PJ.; ''Site recognition and substrate screens for PKN family proteins.''; PubMed Europe PMC
  60. Vidal A, Koff A.; ''Cell-cycle inhibitors: three families united by a common cause.''; PubMed Europe PMC
  61. Wells A.; ''EGF receptor.''; PubMed Europe PMC
  62. Roskoski R.; ''ERK1/2 MAP kinases: structure, function, and regulation.''; PubMed Europe PMC
  63. Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T.; ''STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.''; PubMed Europe PMC
  64. Misaki K, Mukai H, Yoshinaga C, Oishi K, Isagawa T, Takahashi M, Ohsumi K, Kishimoto T, Ono Y.; ''PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division.''; PubMed Europe PMC
  65. Matsuzawa K, Kosako H, Inagaki N, Shibata H, Mukai H, Ono Y, Amano M, Kaibuchi K, Matsuura Y, Azuma I, Inagaki M.; ''Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.''; PubMed Europe PMC
  66. Jung JH, Traugh JA.; ''Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.''; PubMed Europe PMC
  67. Li R, Zhang B, Zheng Y.; ''Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190.''; PubMed Europe PMC
  68. McKay MM, Morrison DK.; ''Integrating signals from RTKs to ERK/MAPK.''; PubMed Europe PMC
  69. Nizet V, Johnson RS.; ''Interdependence of hypoxic and innate immune responses.''; PubMed Europe PMC
  70. King PD, Lubeck BA, Lapinski PE.; ''Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.''; PubMed Europe PMC
  71. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.; ''The retinoblastoma protein binds to a family of E2F transcription factors.''; PubMed Europe PMC
  72. Fernandez-Borja M, Janssen L, Verwoerd D, Hordijk P, Neefjes J.; ''RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1.''; PubMed Europe PMC
  73. Yoshinaga C, Mukai H, Toshimori M, Miyamoto M, Ono Y.; ''Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain.''; PubMed Europe PMC
  74. Li F, Higgs HN.; ''The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition.''; PubMed Europe PMC
  75. Kühn S, Geyer M.; ''Formins as effector proteins of Rho GTPases.''; PubMed Europe PMC
  76. Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC.; ''Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.''; PubMed Europe PMC
  77. Gao Y, Cimica V, Reich NC.; ''Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.''; PubMed Europe PMC
  78. Cseh B, Doma E, Baccarini M.; ''"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway.''; PubMed Europe PMC
  79. Koncina E, Roth L, Gonthier B, Bagnard D.; ''Role of semaphorins during axon growth and guidance.''; PubMed Europe PMC
  80. Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.; ''Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.''; PubMed Europe PMC
  81. Zhang B, Chernoff J, Zheng Y.; ''Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.''; PubMed Europe PMC
  82. Chen HY, Shen CH, Tsai YT, Lin FC, Huang YP, Chen RH.; ''Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin.''; PubMed Europe PMC
  83. Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM.; ''HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.''; PubMed Europe PMC
  84. Yang J, Huang J, Dasgupta M, Sears N, Miyagi M, Wang B, Chance MR, Chen X, Du Y, Wang Y, An L, Wang Q, Lu T, Zhang X, Wang Z, Stark GR.; ''Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.''; PubMed Europe PMC
  85. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y.; ''Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.''; PubMed Europe PMC
  86. Lane J, Martin T, Weeks HP, Jiang WG.; ''Structure and role of WASP and WAVE in Rho GTPase signalling in cancer.''; PubMed Europe PMC
  87. Zhang H.; ''Life without kinase: cyclin E promotes DNA replication licensing and beyond.''; PubMed Europe PMC
  88. Carpenter G.; ''Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways.''; PubMed Europe PMC
  89. Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS.; ''Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.''; PubMed Europe PMC
  90. Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ.; ''Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture.''; PubMed Europe PMC
  91. Zhang W, Benson DL.; ''Targeting and clustering citron to synapses.''; PubMed Europe PMC
  92. Scheffzek K, Ahmadian MR, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A.; ''The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.''; PubMed Europe PMC
  93. Cobrinik D.; ''Pocket proteins and cell cycle control.''; PubMed Europe PMC
  94. Semenza GL.; ''Life with oxygen.''; PubMed Europe PMC
  95. Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L.; ''The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.''; PubMed Europe PMC
  96. Yamashiro S, Totsukawa G, Yamakita Y, Sasaki Y, Madaule P, Ishizaki T, Narumiya S, Matsumura F.; ''Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II.''; PubMed Europe PMC
  97. Depoortere F, Van Keymeulen A, Lukas J, Costagliola S, Bartkova J, Dumont JE, Bartek J, Roger PP, Dremier S.; ''A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes.''; PubMed Europe PMC
  98. Roskoski R.; ''RAF protein-serine/threonine kinases: structure and regulation.''; PubMed Europe PMC
  99. Ahmadian MR, Stege P, Scheffzek K, Wittinghofer A.; ''Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.''; PubMed Europe PMC
  100. Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA.; ''Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.''; PubMed Europe PMC
  101. Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK.; ''Brk is coamplified with ErbB2 to promote proliferation in breast cancer.''; PubMed Europe PMC
  102. Miah S, Goel RK, Dai C, Kalra N, Beaton-Brown E, Bagu ET, Bonham K, Lukong KE.; ''BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.''; PubMed Europe PMC
  103. Isobe A, Takeda T, Sakata M, Yamamoto T, Minekawa R, Hayashi M, Auernhammer CJ, Tasaka K, Murata Y.; ''STAT3-mediated constitutive expression of SOCS3 in an undifferentiated rat trophoblast-like cell line.''; PubMed Europe PMC
  104. Kang SA, Lee ST.; ''PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.''; PubMed Europe PMC
  105. Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.; ''Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.''; PubMed Europe PMC
  106. Hamaguchi T, Ito M, Feng J, Seko T, Koyama M, Machida H, Takase K, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T.; ''Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N.''; PubMed Europe PMC
  107. Watanabe S, De Zan T, Ishizaki T, Narumiya S.; ''Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.''; PubMed Europe PMC
  108. Loenarz C, Schofield CJ.; ''Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.''; PubMed Europe PMC
  109. Goel RK, Lukong KE.; ''Tracing the footprints of the breast cancer oncogene BRK - Past till present.''; PubMed Europe PMC
  110. Yayoshi-Yamamoto S, Taniuchi I, Watanabe T.; ''FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.''; PubMed Europe PMC
  111. Mukai H, Toshimori M, Shibata H, Takanaga H, Kitagawa M, Miyahara M, Shimakawa M, Ono Y.; ''Interaction of PKN with alpha-actinin.''; PubMed Europe PMC
  112. Turjanski AG, Vaqué JP, Gutkind JS.; ''MAP kinases and the control of nuclear events.''; PubMed Europe PMC
  113. Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, Iwamatsu A, Kaibuchi K.; ''Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1.''; PubMed Europe PMC
  114. Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, Settleman J, Chen RH.; ''Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.''; PubMed Europe PMC
  115. Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ, Ratcliffe PJ.; ''Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.''; PubMed Europe PMC
  116. Vega FM, Fruhwirth G, Ng T, Ridley AJ.; ''RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.''; PubMed Europe PMC
  117. Zheng Y, Asara JM, Tyner AL.; ''Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.''; PubMed Europe PMC
  118. Gruneberg U, Neef R, Li X, Chan EH, Chalamalasetty RB, Nigg EA, Barr FA.; ''KIF14 and citron kinase act together to promote efficient cytokinesis.''; PubMed Europe PMC
  119. Schlessinger J.; ''Ligand-induced, receptor-mediated dimerization and activation of EGF receptor.''; PubMed Europe PMC
  120. White CD, Erdemir HH, Sacks DB.; ''IQGAP1 and its binding proteins control diverse biological functions.''; PubMed Europe PMC
  121. Wiejak J, Dunlop J, Gao S, Borland G, Yarwood SJ.; ''Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.''; PubMed Europe PMC
  122. Lukong KE, Larocque D, Tyner AL, Richard S.; ''Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.''; PubMed Europe PMC
  123. Di Cunto F, Calautti E, Hsiao J, Ong L, Topley G, Turco E, Dotto GP.; ''Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron.''; PubMed Europe PMC
  124. Serres MP, Kossatz U, Chi Y, Roberts JM, Malek NP, Besson A.; ''p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.''; PubMed Europe PMC
  125. Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R.; ''Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC.''; PubMed Europe PMC
  126. Daniels RH, Bokoch GM.; ''p21-activated protein kinase: a crucial component of morphological signaling?''; PubMed Europe PMC
  127. Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.; ''Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.''; PubMed Europe PMC
  128. Bashour AM, Fullerton AT, Hart MJ, Bloom GS.; ''IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments.''; PubMed Europe PMC
  129. Pouysségur J, Dayan F, Mazure NM.; ''Hypoxia signalling in cancer and approaches to enforce tumour regression.''; PubMed Europe PMC
  130. Kyriakis JM, Avruch J.; ''Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.''; PubMed Europe PMC
  131. Coyle JH, Guzik BW, Bor YC, Jin L, Eisner-Smerage L, Taylor SJ, Rekosh D, Hammarskjöld ML.; ''Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.''; PubMed Europe PMC
  132. Sadasivam S, DeCaprio JA.; ''The DREAM complex: master coordinator of cell cycle-dependent gene expression.''; PubMed Europe PMC
  133. Cheng M, Sexl V, Sherr CJ, Roussel MF.; ''Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).''; PubMed Europe PMC
  134. Roskoski R.; ''MEK1/2 dual-specificity protein kinases: structure and regulation.''; PubMed Europe PMC
  135. Swart-Mataraza JM, Li Z, Sacks DB.; ''IQGAP1 is a component of Cdc42 signaling to the cytoskeleton.''; PubMed Europe PMC
  136. Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T.; ''The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.''; PubMed Europe PMC
  137. Parrini MC, Lei M, Harrison SC, Mayer BJ.; ''Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.''; PubMed Europe PMC
  138. Plotnikov A, Zehorai E, Procaccia S, Seger R.; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; PubMed Europe PMC
  139. Guan KL, Jenkins CW, Li Y, O'Keefe CL, Noh S, Wu X, Zariwala M, Matera AG, Xiong Y.; ''Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.''; PubMed Europe PMC
  140. Fan G, Aleem S, Yang M, Miller WT, Tonks NK.; ''Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.''; PubMed Europe PMC
  141. Bagchi S, Weinmann R, Raychaudhuri P.; ''The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F.''; PubMed Europe PMC
  142. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA.; ''Mutations of the BRAF gene in human cancer.''; PubMed Europe PMC
  143. Pasterkamp RJ, Verhaagen J.; ''Semaphorins in axon regeneration: developmental guidance molecules gone wrong?''; PubMed Europe PMC
  144. Dettori R, Sonzogni S, Meyer L, Lopez-Garcia LA, Morrice NA, Zeuzem S, Engel M, Piiper A, Neimanis S, Frödin M, Biondi RM.; ''Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).''; PubMed Europe PMC
  145. Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.; ''Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.''; PubMed Europe PMC
  146. Ostrander JH, Daniel AR, Lofgren K, Kleer CG, Lange CA.; ''Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.''; PubMed Europe PMC
  147. Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.; ''Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.''; PubMed Europe PMC
  148. Seth A, Otomo C, Rosen MK.; ''Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.''; PubMed Europe PMC
  149. Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S.; ''A novel partner for the GTP-bound forms of rho and rac.''; PubMed Europe PMC
  150. Roberts PJ, Der CJ.; ''Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.''; PubMed Europe PMC
  151. Herbst RS.; ''Review of epidermal growth factor receptor biology.''; PubMed Europe PMC
  152. Gasman S, Kalaidzidis Y, Zerial M.; ''RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.''; PubMed Europe PMC
  153. Zhou Y, Gunput RA, Pasterkamp RJ.; ''Semaphorin signaling: progress made and promises ahead.''; PubMed Europe PMC
  154. Kato T, Gotoh Y, Hoffmann A, Ono Y.; ''Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.''; PubMed Europe PMC
  155. Kaelin WG, Ratcliffe PJ.; ''Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.''; PubMed Europe PMC
  156. Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A.; ''STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.''; PubMed Europe PMC
  157. Lukong KE, Richard S.; ''Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.''; PubMed Europe PMC
  158. Nezami AG, Poy F, Eck MJ.; ''Structure of the autoinhibitory switch in formin mDia1.''; PubMed Europe PMC
  159. Tanizaki J, Okamoto I, Sakai K, Nakagawa K.; ''Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification.''; PubMed Europe PMC
  160. Zong H, Raman N, Mickelson-Young LA, Atkinson SJ, Quilliam LA.; ''Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation.''; PubMed Europe PMC
  161. Romero S, Le Clainche C, Didry D, Egile C, Pantaloni D, Carlier MF.; ''Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis.''; PubMed Europe PMC
  162. Fan L, Pellegrin S, Scott A, Mellor H.; ''The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells.''; PubMed Europe PMC
  163. Cheng L, Zhang J, Ahmad S, Rozier L, Yu H, Deng H, Mao Y.; ''Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment.''; PubMed Europe PMC
  164. Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA.; ''Regulated association of protein kinase B/Akt with breast tumor kinase.''; PubMed Europe PMC
  165. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G.; ''The E2F1-3 transcription factors are essential for cellular proliferation.''; PubMed Europe PMC
  166. Brown MD, Sacks DB.; ''Protein scaffolds in MAP kinase signalling.''; PubMed Europe PMC
  167. Hiebert SW.; ''Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.''; PubMed Europe PMC
  168. Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR.; ''Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).''; PubMed Europe PMC


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102035view16:22, 26 November 2018Marvin M2Ontology Term : 'PW:0000003' removed !
102034view16:21, 26 November 2018Marvin M2Ontology Term : 'kinase mediated signaling pathway' added !
101698view14:35, 1 November 2018DeSlOntology Term : 'signaling pathway' added !
101490view11:35, 1 November 2018ReactomeTeamreactome version 66
101027view21:15, 31 October 2018ReactomeTeamreactome version 65
100725view20:11, 31 October 2018ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
AKT1 ProteinP31749 (Uniprot-TrEMBL)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ARAP1 ProteinQ96P48 (Uniprot-TrEMBL)
ARAP1ProteinQ96P48 (Uniprot-TrEMBL)
ARHGAP35 ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGAP35ProteinQ9NRY4 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
BCAR1 ProteinP56945 (Uniprot-TrEMBL)
BCAR1ProteinP56945 (Uniprot-TrEMBL)
CBLProteinP22681 (Uniprot-TrEMBL)
CCND1 ProteinP24385 (Uniprot-TrEMBL)
CCNE1 ProteinP24864 (Uniprot-TrEMBL)
CDK2 ProteinP24941 (Uniprot-TrEMBL)
CDK4 ProteinP11802 (Uniprot-TrEMBL)
CDKN1B ProteinP46527 (Uniprot-TrEMBL)
CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))ComplexR-HSA-8848419 (Reactome)
CRK ProteinP46108 (Uniprot-TrEMBL)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
DEXA MetaboliteCHEBI:41879 (ChEBI)
DOCK1 ProteinQ14185 (Uniprot-TrEMBL)
DOK1 ProteinQ99704 (Uniprot-TrEMBL)
DOK1ProteinQ99704 (Uniprot-TrEMBL)
EGFR ProteinP00533 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO2 ProteinQ96JJ3 (Uniprot-TrEMBL)
EPAS1 ProteinQ99814 (Uniprot-TrEMBL)
EPAS1ProteinQ99814 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GPNMB ProteinQ14956 (Uniprot-TrEMBL)
GPNMBProteinQ14956 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HBEGF(63-148) ProteinQ99075 (Uniprot-TrEMBL)
HBEGF:EGFR:GPNMBComplexR-HSA-8857546 (Reactome)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2ComplexR-HSA-8857567 (Reactome)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2ComplexR-HSA-8857574 (Reactome)
HBEGF:EGFR:p-Y525-GPNMBComplexR-HSA-8857556 (Reactome)
HBEGF:EGFRComplexR-HSA-8857547 (Reactome)
HIF1A ProteinQ16665 (Uniprot-TrEMBL)
HIF1A,EPAS1:PTK6 GeneComplexR-HSA-8848808 (Reactome)
HIF1A,EPAS1ComplexR-HSA-8848802 (Reactome)
HIF1AProteinQ16665 (Uniprot-TrEMBL)
HRAS ProteinP01112 (Uniprot-TrEMBL)
KHDRBS1 ProteinQ07666 (Uniprot-TrEMBL)
KHDRBS1ProteinQ07666 (Uniprot-TrEMBL)