FABP4 in ovarian cancer (Homo sapiens)

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1LegendTumor cellmir-409-3p mimicPotential therapeutic strategiesHypoxiaAggressive diseaseFABP4MIR409FABP4siRNA


Description

Regulation of FABP4 in ovarian cancer. FABP4 (fatty acid binding protein) can substantially increase metastatic potential of ovarian cancer cells, and leads to more aggressive disease. Mir-409-3p negatively regulates FABP4 in ovarian cancer cells, and mir-409-3p is decreased in hypoxic conditions. Pink arrows indicates potential therapuetic therapeutic stratgeies; in Gharpure et al, DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA was shown to inhibit tumor progression. Description was adapted from Gharpure et al.

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Ontology Terms

 

Bibliography

  1. Gharpure KM, Pradeep S, Sans M, Rupaimoole R, Ivan C, Wu SY, Bayraktar E, Nagaraja AS, Mangala LS, Zhang X, Haemmerle M, Hu W, Rodriguez-Aguayo C, McGuire M, Mak CSL, Chen X, Tran MA, Villar-Prados A, Pena GA, Kondetimmanahalli R, Nini R, Koppula P, Ram P, Liu J, Lopez-Berestein G, Baggerly K, S Eberlin L, Sood AK; ''FABP4 as a key determinant of metastatic potential of ovarian cancer.''; Nat Commun, 2018 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
99020view22:01, 23 October 2018KhanspersModified description
99019view21:56, 23 October 2018KhanspersOntology Term : 'microRNA pathway' added !
99018view21:56, 23 October 2018KhanspersOntology Term : 'ovarian cancer' added !
99017view21:55, 23 October 2018KhanspersNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
FABP4GeneProductENSG00000170323 (Ensembl)
MIR409RnaENSG00000199107 (Ensembl)

Annotated Interactions

No annotated interactions

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