MicroRNA network associated with chronic lymphocytic leukemia (Homo sapiens)

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132B cellLegenddel17pEffect of deletion/mutationIndolent CLLZAP70BCL2TP53MIR34AMIR34BMIR34CMIR15AMIR16-1del11qdel13qMCL1Aggressive CLL


MicroRNA network associated with Chronic lymphocytic leukemia (CLL). The pink interactions represent effects of deletions/mutations. The mir15/16-p53 feedback circuit was originally described in Fabbri et al.

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Ontology Terms



  1. Ciccone M, Calin GA; ''MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights.''; Microrna, 2016 PubMed Europe PMC Scholia
  2. Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell'Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ, Calin GA, Croce CM; ''Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.''; JAMA, 2011 PubMed Europe PMC Scholia
  3. Auer RL, Riaz S, Cotter FE; ''The 13q and 11q B-cell chronic lymphocytic leukaemia-associated regions derive from a common ancestral region in the zebrafish.''; Br J Haematol, 2007 PubMed Europe PMC Scholia


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102102view18:58, 29 November 2018KhanspersModified title
99011view21:26, 22 October 2018KhanspersModified title
99010view21:25, 22 October 2018KhanspersModified description
99009view21:21, 22 October 2018Khanspers
99008view21:17, 22 October 2018KhanspersOntology Term : 'altered p53 signaling pathway' added !
99007view21:17, 22 October 2018KhanspersOntology Term : 'B cell' added !
99006view21:17, 22 October 2018KhanspersOntology Term : 'chronic lymphocytic leukemia' added !
99005view21:12, 22 October 2018KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
BCL2GeneProductENSG00000171791 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MIR15AGeneProductENSG00000283785 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR34ARnaENSG00000284357 (Ensembl)
MIR34BRnaENSG00000207811 (Ensembl)
MIR34CRnaENSG00000207562 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
ZAP70GeneProductENSG00000115085 (Ensembl)

Annotated Interactions

No annotated interactions

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