Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) (Mus musculus)

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44434124444LXRalpha/betaSterol effluxothersCh25hHmgcrDhcr7DHCR24Nr1h3Abca1Acetyl-CoACE(16:1)FasnAcot17alpha-hydroxycholesterolBloch Pathway9Z-palmitoleic acidSrebf1Soat1Acetoacetyl-CoAHMG-CoAMevalonic acidMevalonate-5-PMevalonate-5-PPIsopentenyl-PPDimethylallyl-PPGeranyl-PPFarnesyl-PPSqualeneSqualene-2,3-epoxideDiepoxy-squaleneLanosterol24,25-epoxycholesterol24,25-dihydrolanosterol32-hydroxylanosterol4,4-dimethylcholesta-5,8,24-trienol4,4-dimethylcholest-8-enol14-demethyl-lanosterol4-alpha-methylcholest-8-enolZymosterol4-alpha-methyl-cholest-8-enoneZymostenolLathosterol7-dehdrocholesterolCholestadienol7-dehydodesmosterolDesmosterolCholesterolSc5dEbpNsdhlCyp51Tm7fs2Msmo1Hsd17b7Dhcr247-oxocholesterolCholestenone4beta-hydroxycholesterol24S-hydroxycholesterol25-hydroxycholesterol27-hydroxycholesterolCholesteryl esters (CE)Cyp46a1Cyp27a1Acyl-CoASoat2Acot2Hmgcs1Hmgcs2MvkPmvkMvdSqleIdi1Idi2Fdft1Ggps1FdpsLssKandutsch-Russell PathwayPreSqualeneCyp51Dhcr7Dhcr24CE(18:1)Nr1h2Abcg1Mylip (IDOL)LDLR degradationSrebf2Sterol biosynthesisAcsl1Acsl3Acsl4Elovl2Elovl3Elovl4Elovl5Fads1Fads2Scd1Scd2Acot1Acot2Fatty acid biosynthesisOleic acid4-methyl zymostenol4-methyl zymostenone14-methyl-4-carboxyzymostenone1dihydro-FF-MASdihydro-T-MAS111Cyp51A14TM7SF24SC4MOLNSDHL44LBR4-methyl zymosterol4-methyl zymosterone4-methyl-4-carboxyzymosteroneFF-MAST-MASDHCR14SC4MOLNSDHLLBR4HSD17B74441SC4MOLNSDHLHSD17B7Cyp51A14HSD17B7444444444444444


Description

This pathway is inspired by the Lipidmaps>Sterol lipids expended pathway display [1] and extended with Scheme 1 from Acimovic et al (2013).

Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol [Bae et al, 1997].

Dashed lines indicate that multiple steps are involved to create the final product. Several regulatory effects concerning the metabolites of cholesterol have been indicated as well. The content from the Bloch and Kandutsch-Russel pathways have been checked against literature, and discrepancies compared to the original LipidMaps pathway have been coloured turquoise.

Quality Tags

Ontology Terms

 

Bibliography

  1. Ačimovič J, Rozman D; ''''; ,
  2. Bogan RL, Debarber AE, Hennebold JD; ''Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.''; Biol Reprod, 2012 PubMed
  3. Ačimovič J, Rozman D; ''''; , PubMed
  4. Ačimovič J, Rozman D; ''Steroidal triterpenes of cholesterol synthesis.''; Molecules, 2013 PubMed

History

View all...
CompareRevisionActionTimeUserComment
98941view13:06, 16 October 2018DeSlFixed lit. refs.
98769view14:40, 5 October 2018DeSlConnected DHCR24 to last conversion from Bloch to KR PW
98768view14:35, 5 October 2018DeSlAdded more info from lit. ref
98752view15:31, 4 October 2018DeSlModified description
98751view15:24, 4 October 2018DeSlConnected unconnected lines
98668view15:43, 27 September 2018DeSlModified description
98667view15:42, 27 September 2018DeSlModified description
98666view15:42, 27 September 2018DeSlModified description
98665view15:37, 27 September 2018DeSlAdded last enzymes needed for conversions.
98664view15:25, 27 September 2018DeSlAdded more info from lit. ref (on bloch PW).
98657view09:01, 27 September 2018DeSlAdded more info from lit. ref (more detailed steps)
98654view15:54, 26 September 2018DeSlAdded more info from lit ref, changed colour for clarity.
98653view15:51, 26 September 2018DeSlAdded info from lit. ref.
98652view15:39, 26 September 2018DeSlAdded last part of missing signalling track
98651view15:23, 26 September 2018DeSlAdded more details on signalling function of metabolites.
98640view15:38, 24 September 2018DeSlAdded some missing nodes
98639view15:35, 24 September 2018DeSlConnected groups of enzymes correclty, changed layout.
98638view14:24, 24 September 2018DeSlModified title
98637view14:21, 24 September 2018DeSlModified title
98610view12:42, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98576view15:53, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-demethyl-lanosterolMetaboliteLMST01010176 (LIPID MAPS)
24,25-dihydrolanosterolMetaboliteLMST01010087 (LIPID MAPS)
24,25-epoxycholesterolMetaboliteLMST01010012 (LIPID MAPS)
24S-hydroxycholesterolMetaboliteLMST01010019 (LIPID MAPS)
25-hydroxycholesterolMetaboliteLMST01010018 (LIPID MAPS)
27-hydroxycholesterolMetaboliteLMST01010057 (LIPID MAPS)
32-hydroxylanosterolMetaboliteLMST01010124 (LIPID MAPS)
4,4-dimethylcholest-8-enolMetaboliteLMST01010225 (LIPID MAPS)
4,4-dimethylcholesta- 5,8,24-trienolMetaboliteLMST01010149 (LIPID MAPS)
4-alpha-methyl-cholest-8-enoneMetaboliteLMST01010236 (LIPID MAPS)
4-alpha-methylcholest-8-enolMetaboliteLMST01010197 (LIPID MAPS)
4-methyl zymostenolMetabolite22212495 (PubChem-compound)
4-methyl zymostenoneMetabolite
4-methyl zymosterolMetabolite
4-methyl zymosteroneMetabolite
4-methyl-4-carboxy zymostenoneMetabolite
4-methyl-4-carboxy zymosteroneMetabolite
4beta-hydroxycholesterolMetaboliteLMST01010014 (LIPID MAPS)
7-dehdrocholesterolMetaboliteLMST01010069 (LIPID MAPS)
7-dehydodesmosterolMetaboliteLMST01010121 (LIPID MAPS)
7-oxocholesterolMetaboliteLMST01010049 (LIPID MAPS)
7alpha-hydroxycholesterolMetaboliteLMST01010013 (LIPID MAPS)
9Z-palmitoleic acidMetabolite
Abca1Protein
Abcg1Protein
Acetoacetyl-CoAMetaboliteLMFA07050030 (LIPID MAPS)
Acetyl-CoAMetaboliteLMFA07050281 (LIPID MAPS)
Acot1Protein
Acot1GeneProduct26897 (Entrez Gene)
Acot2Protein
Acot2GeneProduct171210 (Entrez Gene)
Acsl1Protein
Acsl3Protein
Acsl4Protein
Acyl-CoAMetaboliteLMFA07050000 (LIPID MAPS)
Bloch PathwayPathway
CE(16:1)Metabolite
CE(18:1)Metabolite
Ch25hGeneProduct12642 (Entrez Gene)
CholestadienolMetaboliteLMST01010206 (LIPID MAPS) aka 24-dehydrolathosterol
CholestenoneMetaboliteLMST01010015 (LIPID MAPS)
CholesterolMetaboliteLMST01010001 (LIPID MAPS)
Cholesteryl esters (CE)Metabolite
Cyp27a1GeneProduct104086 (Entrez Gene)
Cyp46a1GeneProduct13116 (Entrez Gene)
Cyp51GeneProduct13121 (Entrez Gene)
Cyp51A1ProteinQ8K0C4 (Uniprot-TrEMBL)
DHCR14Protein
DHCR24ProteinQ8VCH6 (Uniprot-TrEMBL)
DesmosterolMetaboliteLMST01010016 (LIPID MAPS)
Dhcr24GeneProduct74754 (Entrez Gene)
Dhcr7GeneProduct13360 (Entrez Gene)
Diepoxy-squaleneMetaboliteLMPR01060038 (LIPID MAPS)
Dimethylallyl-PPMetaboliteLMPR01010001 (LIPID MAPS)
EbpGeneProduct13595 (Entrez Gene)
Elovl2Protein
Elovl3Protein
Elovl4Protein
Elovl5Protein
FF-MASMetaboliteaka 14-demethyl-14-dehydrolanosterol
Fads1Protein
Fads2Protein
Farnesyl-PPMetaboliteLMPR0103010002 (LIPID MAPS)
FasnProtein
Fdft1GeneProduct14137 (Entrez Gene)
FdpsGeneProduct110196 (Entrez Gene)
Geranyl-PPMetaboliteLMPR0102010001 (LIPID MAPS)
Ggps1GeneProduct14593 (Entrez Gene)
HMG-CoAMetaboliteLMFA07050116 (LIPID MAPS)
HSD17B7Protein
HmgcrGeneProduct15357 (Entrez Gene)
Hmgcs1GeneProduct208715 (Entrez Gene)
Hmgcs2GeneProduct15360 (Entrez Gene)
Hsd17b7GeneProduct15490 (Entrez Gene)
Idi1GeneProduct319554 (Entrez Gene)
Idi2GeneProduct320581 (Entrez Gene)
Isopentenyl-PPMetaboliteLMPR01010008 (LIPID MAPS)
Kandutsch-

Russell

Pathway
Pathway
LBRProteinQ3U9G9 (Uniprot-TrEMBL)
LanosterolMetaboliteLMST01010017 (LIPID MAPS)
LathosterolMetaboliteLMST01010089 (LIPID MAPS)
LssGeneProduct16987 (Entrez Gene)
Mevalonate-5-PMetaboliteLMFA01050415 (LIPID MAPS)
Mevalonate-5-PPMetaboliteLMFA01050416 (LIPID MAPS)
Mevalonic acidMetaboliteLMFA01050352 (LIPID MAPS)
Msmo1GeneProduct66234 (Entrez Gene) aka Sc4mol
MvdGeneProduct192156 (Entrez Gene)
MvkGeneProduct17855 (Entrez Gene)
Mylip (IDOL)Protein
NSDHLProteinQ9R1J0 (Uniprot-TrEMBL)
Nr1h2Protein
Nr1h3Protein
NsdhlGeneProduct18194 (Entrez Gene)
Oleic acidMetabolite
PmvkGeneProduct68603 (Entrez Gene)
PreSqualeneMetabolite
SC4MOLProteinQ9CRA4 (Uniprot-TrEMBL)
Sc5dGeneProduct235293 (Entrez Gene)
Scd1Protein
Scd2Protein
Soat1GeneProduct20652 (Entrez Gene)
Soat2GeneProduct223920 (Entrez Gene)
SqleGeneProduct20775 (Entrez Gene)
Squalene-2,3-epoxideMetaboliteLMPR0106010010 (LIPID MAPS)
SqualeneMetaboliteLMPR0106010002 (LIPID MAPS)
Srebf1Protein
Srebf2Protein
T-MASMetabolite
TM7SF2ProteinQ71KT5 (Uniprot-TrEMBL)
Tm7fs2GeneProduct73166 (Entrez Gene)
ZymostenolMetaboliteLMST01010096 (LIPID MAPS)
ZymosterolMetaboliteLMST01010066 (LIPID MAPS)
dihydro-FF-MASMetabolite
dihydro-T-MASMetabolite

Annotated Interactions

No annotated interactions

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