Vitamins A and D - action mechanisms (Homo sapiens)

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1Retinoic acidGutVDREEffector cellVitamin D-rich dietVitamin A-rich dietUV-B lightSkinLiverKidneybeta-carotene7-Dehydrocholesterolretinol (vit A)retinalATRA9-cis-Retinoic acid25(OH)D3VDRVitamin D3Previtamin D31,25(OH)2D325(OH)D31,25(OH)2D3RXRNucleusRXRRXRRARERARRXRNucleusEffector cell


The active forms of vitamins A and D both activate nuclear receptors. The generation of the vitamin metabolites and their role in the activation of the nuclear receptors is shown in the pathway.

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Ontology Terms



  1. Mora JR, Iwata M, von Andrian UH; ''Vitamin effects on the immune system: vitamins A and D take centre stage.''; Nat Rev Immunol, 2008 PubMed Europe PMC Scholia


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106136view12:03, 16 August 2019MaintBotHMDB identifier normalization
98582view17:56, 17 September 2018AlexanderPicoupdated outdated chebi
98552view18:06, 16 September 2018AlexanderPicoupdated outdated chebi
98548view21:29, 14 September 2018Khanspersconverted interaction to graphical line
98503view09:22, 13 September 2018SusanModified description
98502view09:18, 13 September 2018SusanAdd literature
98501view09:08, 13 September 2018SusanOntology Term : 'vitamin D metabolic pathway' added !
98500view09:07, 13 September 2018SusanOntology Term : 'vitamin D signaling pathway' added !
98499view09:07, 13 September 2018SusanOntology Term : 'vitamin A and metabolites signaling pathway' added !
98498view09:04, 13 September 2018SusanNew pathway

External references


View all...
NameTypeDatabase referenceComment
1,25(OH)2D3MetaboliteHMDB0000969 (HMDB)
25(OH)D3MetaboliteCHEBI:17933 (ChEBI)
7-DehydrocholesterolMetaboliteHMDB0000032 (HMDB)
9-cis-Retinoic acidMetaboliteHMDB0002369 (HMDB)
ATRAMetaboliteCHEBI:50648 (ChEBI)
Previtamin D3MetaboliteHMDB0006500 (HMDB)
RARGeneProductENSG00000131759 (Ensembl)
RXRGeneProductENSG00000131759 (Ensembl)
RXRGeneProductENSG00000186350 (Ensembl)
VDRGeneProductENSG00000111424 (Ensembl)
Vitamin D3MetaboliteCHEBI:28940 (ChEBI)
beta-caroteneMetaboliteCHEBI:17579 (ChEBI)
retinalMetaboliteCHEBI:15035 (ChEBI)
retinol (vit A)MetaboliteCHEBI:17336 (ChEBI)

Annotated Interactions

No annotated interactions

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