ncRNAs involved in Wnt signaling in hepatocellular carcinoma (Homo sapiens)

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Scaffold1, 3222222NucleusCancer stem cellTranscriptional ActivationFrizzled LigandsEpithelial-mesenchymal transitionSOX7CSNK2A3lnc-beta-catmDVL2lncTCF7DVL1ROR1CCND3WNT3AMIR214WNT5ATCF7L2WNT16HBX-LINE1AXIN1WNT16KREM1WNT7AWNT11CSNK1A1LDANCRCSNK1A1FOSL1LEF1WNT10ADVL3FZD4RYKlncRNA-LALR1WNT5BFZD3CSNK2BLRP6JUNCSNK2A1WNT4FZD9UFC1WNT10BFZD10TCF7FZD8TCF7L1CCND1CSNK2A2GSK3BMIR1247APCFZD2LRP526S Proteasome DegradationMIR452CHD8WNT2BMYCFZD7WNT3ELAVL1CSNK1EFRAT1WNT6FZD5WNT2CTNNB1FZD6CCND2EZH2WNT1PLAUFZD1WNT7BPPPROR2PCTNNB1PPCTNNB1UbPDKK1DKK2DKK4SOSTSERPINF1FRAT2CTNNB1SFRP1SFRP2SFRP4SFRP5NOTUMCER1WIF1PORCNNKD1NKD2CXXC4SENP2NLKPCTNNBIP1SOX17CTBP1CTBP2MIR15BMIR195MTDHMIR18AKLF4MIR320A


Description

This pathway is based on the Wnt Signaling Pathway with information on lncRNA involvement in hepatocellular carcinoma from Fig 3 in Klingenberg et al.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC
  2. Vasuri F, Visani M, Acquaviva G, Brand T, Fiorentino M, Pession A, Tallini G, D'Errico A, de Biase D; ''Role of microRNAs in the main molecular pathways of hepatocellular carcinoma.''; World J Gastroenterol, 2018 PubMed Europe PMC
  3. Klingenberg M, Matsuda A, Diederichs S, Patel T; ''Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.''; J Hepatol, 2017 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
103459view23:59, 4 March 2019KhanspersAdded miRNA regulation from Vasuri et al
98467view19:13, 7 September 2018KhanspersModified description
98462view18:04, 7 September 2018KhanspersModified title
98461view18:01, 7 September 2018KhanspersModified description
98460view18:01, 7 September 2018KhanspersOntology Term : 'hepatocellular carcinoma' added !
98459view18:00, 7 September 2018KhanspersOntology Term : 'altered Wnt signaling pathway' added !
98458view18:00, 7 September 2018KhanspersModified description
98457view17:54, 7 September 2018Khanspersadded lit ref
98456view17:53, 7 September 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProductENSG00000178585 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
DANCRRnaENSG00000226950 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ELAVL1GeneProductENSG00000066044 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HBX-LINE1GeneProduct
JUNGeneProduct3725 (Entrez Gene)
KLF4GeneProductENSG00000136826 (Ensembl)
KREM1GeneProduct83999 (Entrez Gene)
LEF1GeneProductENSG00000138795 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MIR1247GeneProductMIMAT0005899 (miRBase mature sequence)
MIR15BGeneProductMIMAT0000417 (miRBase mature sequence)
MIR18AGeneProductENSG00000283815 (Ensembl)
MIR195GeneProductMIMAT0000461 (miRBase mature sequence)
MIR214GeneProductMIR214 (HGNC)
MIR320AGeneProductENSG00000208037 (Ensembl)
MIR452GeneProductENSG00000283751 (Ensembl)
MTDHGeneProductENSG00000147649 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NKD1GeneProductENSG00000140807 (Ensembl)
NKD2GeneProductENSG00000145506 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
PLAUGeneProduct5328 (Entrez Gene)
PORCNGeneProductENSG00000102312 (Ensembl)
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RYKGeneProduct6259 (Entrez Gene)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX7GeneProductENSG00000171056 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
UFC1Rna
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
lnc-beta-catmRna
lncRNA-LALR1Rna
lncTCF7Rna

Annotated Interactions

No annotated interactions

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