ncRNAs involved in Wnt signaling in hepatocellular carcinoma (Homo sapiens)

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Scaffold1, 2NucleusFrizzled LigandsEpithelial-mesenchymal transitionCancer stem cellTranscriptional ActivationCSNK1A1WNT16ELAVL1FZD6WNT11CCND2CSNK2A1RYKTCF7L2FZD8MIR214WNT3WNT2WNT7Blnc-beta-catmFZD5CTNNB1UFC1TCF7DANCRLEF1LRP6FZD2WNT1FZD9WNT16WNT10AWNT4lncRNA-LALR1SOX7FRAT1TCF7L1DVL3WNT10BFZD4FOSL1CSNK1A1LFZD126S Proteasome DegradationWNT6FZD7PLAUWNT5BWNT3AFZD10GSK3BCCND1APCJUNWNT7ADVL2EZH2CHD8HBX-LINE1KREM1CCND3CSNK2A3LRP5CSNK1EMIR452MYCCSNK2BlncTCF7ROR1WNT5ADVL1WNT2BFZD3AXIN1CSNK2A2PPPPROR2CTNNB1PPCTNNB1PUbDKK1DKK2DKK4SOSTSERPINF1FRAT2CTNNB1SFRP1SFRP2SFRP4SFRP5NOTUMCER1WIF1PORCNNKD1NKD2CXXC4SENP2NLKPCTNNBIP1SOX17CTBP1CTBP2


Description

This pathway is based on the Wnt Signaling Pathway with information on lncRNA involvement in hepatocellular carcinoma from Fig 3 in Klingenberg et al.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed
  2. Klingenberg M, Matsuda A, Diederichs S, Patel T; ''Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.''; J Hepatol, 2017 PubMed

History

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CompareRevisionActionTimeUserComment
98467view19:13, 7 September 2018KhanspersModified description
98462view18:04, 7 September 2018KhanspersModified title
98461view18:01, 7 September 2018KhanspersModified description
98460view18:01, 7 September 2018KhanspersOntology Term : 'hepatocellular carcinoma' added !
98459view18:00, 7 September 2018KhanspersOntology Term : 'altered Wnt signaling pathway' added !
98458view18:00, 7 September 2018KhanspersModified description
98457view17:54, 7 September 2018Khanspersadded lit ref
98456view17:53, 7 September 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProductENSG00000178585 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
DANCRRnaENSG00000226950 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ELAVL1GeneProductENSG00000066044 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HBX-LINE1GeneProduct
JUNGeneProduct3725 (Entrez Gene)
KREM1GeneProduct83999 (Entrez Gene)
LEF1GeneProductENSG00000138795 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MIR214GeneProductMIR214 (HGNC)
MIR452GeneProductENSG00000283751 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NKD1GeneProductENSG00000140807 (Ensembl)
NKD2GeneProductENSG00000145506 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
PLAUGeneProduct5328 (Entrez Gene)
PORCNGeneProductENSG00000102312 (Ensembl)
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RYKGeneProduct6259 (Entrez Gene)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX7GeneProductENSG00000171056 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
UFC1Rna
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
lnc-beta-catmRna
lncRNA-LALR1Rna
lncTCF7Rna

Annotated Interactions

No annotated interactions

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