miRNAs involvement in the immune response in sepsis (Homo sapiens)

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1DegradationIntravascular coagulationMAP3KsKaposi sarcoma herpesvirus miR-K12-12Tissue Hypo-perfusion(Hypoxia)sFASMYD88Inflammatory ResponseHSP70ICAM1MIR146ATLR7IRAK1IL1AMIR15TLR4MAP3K7LPSMIRLET7EMIRLET7IMIR146BMIR223IRAK4TRAF6TAB2TAB1MIR146AMIR146BMIR155HGIKBKGCHUKIKBKBMIR223MIR16-1MIR16-2MIR199A1MIR199A2MIR126MIR9-1IRAK1IRAK4TRAF6IRAK1IRAK4TRAF6TRAF3TLR8MYD88MIR146BMIR149MIR200BMIR200CMIR203AMIR203BMIR758MAPK14MAPK8IRF5IRF1IRF7IkBIkBPRELANFKB2RELBc-RELNFKB1RELANFKB2RELBc-RELNFKB1NO-inducedVasodilation-HypotensionCOX2-inducedHypotensionTissue injuryMultiple Organ FailureNeutrophil Infiltration/activationEndothelial PermeabilityCXCL8CCL3CCL4VCAM1ELANELCN2HSP70GZMBsFASLNucleusAnti-inflammatory cytokinesIL6MIR21MIR29AMIR145MIR155TNFIL10Pro-inflammatory cytokinesIL10MIR16-1MIR16-2MIR106AMIR106BMIR4461MIR29AMIR16-1MIR16-2MIR19AMIR125B1MIR125B2MIR155MIR187MIR122TNFIL6MIRLET7IMIR146AMIR187


Description

Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis. Cellular immune miRNAs target important components of the NF-κB signaling pathway at different levels regulating the inflammatory response in the pathogenesis of sepsis. Lower part of the figure illustrates the pathophysiological events in sepsis that lead to tissue injury and subsequent multiple organs failure.

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Ontology Terms

 

Bibliography

  1. Giza DE, Fuentes-Mattei E, Bullock MD, Tudor S, Goblirsch MJ, Fabbri M, Lupu F, Yeung SJ, Vasilescu C, Calin GA; ''Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications.''; Cell Death Differ, 2016 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
101725view21:22, 1 November 2018Khanspersminor update
99016view21:13, 23 October 2018Khanspersupdated interaction
99015view21:02, 23 October 2018KhanspersAdded graphic from fig 4 from the same paper, added nucleus and moved existing TNF section
99014view00:00, 23 October 2018Khanspersimproved layout
98988view21:07, 19 October 2018KhanspersModified title
98402view05:48, 1 September 2018EgonwReplaced a secondary ChEBI ID with primary ID.
98392view23:54, 30 August 2018KhanspersOntology Term : 'nuclear factor kappa B signaling pathway' added !
98391view23:54, 30 August 2018KhanspersOntology Term : 'immune response pathway' added !
98390view23:48, 30 August 2018KhanspersModified description
98389view23:46, 30 August 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL3GeneProductENSG00000277632 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
ELANEGeneProductENSG00000197561 (Ensembl)
GZMBGeneProductENSG00000100453 (Ensembl)
HSP70GeneProduct
ICAM1GeneProductENSG00000090339 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF1GeneProductENSG00000125347 (Ensembl)
IRF5GeneProductENSG00000128604 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IkBGeneProductP25963 (Uniprot-TrEMBL) IkB Not Specified
Inflammatory ResponsePathwayWP453 (WikiPathways)
LCN2GeneProductENSG00000148346 (Ensembl)
LPSMetaboliteCHEBI:16412 (ChEBI)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MIR106AGeneProductENSG00000284157 (Ensembl)
MIR106BGeneProductENSG00000208036 (Ensembl)
MIR122GeneProductENSG00000284440 (Ensembl)
MIR125B1GeneProductENSG00000207971 (Ensembl)
MIR125B2GeneProductENSG00000207863 (Ensembl)
MIR126GeneProductENSG00000199161 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR146ARna
MIR146BGeneProductENSG00000202569 (Ensembl)
MIR149GeneProductENSG00000207611 (Ensembl)
MIR15Rna
MIR155GeneProductENSG00000283904 (Ensembl)
MIR155HGGeneProductENSG00000234883 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR16-2GeneProductENSG00000198987 (Ensembl)
MIR187GeneProductENSG00000207797 (Ensembl)
MIR199A1GeneProductENSG00000207752 (Ensembl)
MIR199A2GeneProductENSG00000208024 (Ensembl)
MIR19AGeneProductENSG00000284204 (Ensembl)
MIR200BGeneProductENSG00000207730 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR203AGeneProductENSG00000207568 (Ensembl)
MIR203BGeneProductENSG00000283165 (Ensembl)
MIR21GeneProductENSG00000284190 (Ensembl)
MIR223GeneProductENSG00000274536 (Ensembl)
MIR29AGeneProductMIR29A (HGNC)
MIR4461GeneProductENSG00000263963 (Ensembl)
MIR758GeneProductENSG00000211582 (Ensembl)
MIR9-1GeneProductENSG00000207933 (Ensembl)
MIRLET7ERnaENSG00000198972 (Ensembl)
MIRLET7IGeneProductENSG00000199179 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
RELAGeneProduct5970 (Entrez Gene)
RELBGeneProduct5971 (Entrez Gene)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
VCAM1GeneProductENSG00000162692 (Ensembl)
c-RELGeneProduct5966 (Entrez Gene)
sFASGeneProduct
sFASLGeneProduct

Annotated Interactions

No annotated interactions

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