miRNA degrading enzymes (Homo sapiens)

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1, 2miRNA5'-PXRN1RRP41PNPT13'-P


MicroRNAs (miRNAs) are short RNAs that are important for the regulation of numerous biological processes. Accordingly, the expression of miRNAs is itself tightly controlled by mechanisms acting at the level of transcription as well as processing of miRNA precursors. Recently, active degradation of mature miRNAs has been identified as another mechanism that is important for miRNA homeostasis. In cultured human cells, ribosomal RNA processing protein 41 (RRP41) and polynucleotide phosphorylase (PNPT1) degrade specific miRNAs in the 3'-to-5'direction. (Adapted from Großhans H. et al 2012.)

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Ontology Terms



  1. Rüegger S, Großhans H; ''MicroRNA turnover: when, how, and why.''; Trends Biochem Sci, 2012 PubMed Europe PMC Scholia
  2. Zhang Z, Qin YW, Brewer G, Jing Q; ''MicroRNA degradation and turnover: regulating the regulators.''; Wiley Interdiscip Rev RNA, 2012 PubMed Europe PMC Scholia


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120818view19:10, 11 January 2022KhanspersModified description
120603view22:28, 17 December 2021KhanspersOntology Term : 'microRNA pathway' added !
120602view22:27, 17 December 2021Khanspersupdated interactions
120601view22:22, 17 December 2021KhanspersMOved comment to Description
97927view08:57, 25 June 2018MadeomugaModified description
97923view08:47, 25 June 2018MadeomugaNew pathway

External references


NameTypeDatabase referenceComment
PNPT1GeneProductENSG00000138035 (Ensembl)
RRP41GeneProductQ9NPD3 (Uniprot-TrEMBL)
XRN1GeneProductENSG00000114127 (Ensembl)

Annotated Interactions

No annotated interactions

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