Ferroptosis (Homo sapiens)

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1MitochondriaEndosomeEndosomeAutolysomeSystem Xc-Iron storage(Non-TF bound iron)Fenton reactionFerritin degradationReleased ironROSFerroptosisFTMTFe2+TFRChydrogen peroxideSLC39A14Terpenoid backbonebiosynthesisACSL1FTH1Fe3+PRNPGPX4MAP1LC3BSTEAP3ArachidonateCoQ10MAP1LC3CHMG-CoAPCBP2Acetyl-CoAArachidonyl-CoAgamma-L-Glutamyl-L-cysteineATG5LysoPESehydroxyl radicalVDAC2SorafenibErastinPE-AA/PE-AdARSL3CYBBGlutathioneHMOX1hemeGCLCPE-AA-OH/PE-AdA-OHSLC40A1CoA(R)-MevalonateSLC39A8SLC3A2PCBP1TFIPPVitamin ESLC7A11glutamateSulfasalazineglutamatecystinecysteinecystineGCLMGSSGSSGPE-AA-O-OH/PE-AdA-O-OHALOX15SAT1SAT2TP53LPCAT3ACSL3ACSL4ACSL6ACSL5Fe3+TFTFRCCPFe2+Fe3+Fe2+Fe2+PCBP2Fe3+FTLNCOA4FTH1Fe3+FTLMAP1LC3AATG7Fe3+TFTFRCSLC11A2SLC39A8SLC39A14Fe2+VDAC3Fe2+Erastin


Description

Ferroptosis is a type of programmed cell death that is distinct from apoptosis. It is iron-dependent and is initiated by the failure of the glutathione-dependent antioxidant defenses. Reactive oxygen species (ROS) is produced from accumulated iron and lipid peroxidation.

Ferroptosis is important in several physiological and pathological processes, including cancer cell death and neurodegenerative disease. Ferroptosis can be induced to treat multiple forms of cancer by inhibiting tumor growth, although the exact mechanism is unknown. Ferroptosis has also been linked to neurodegenerative disease, possibly through increased inflammation caused by release of lipid metabolites.

Description adapted from KEGG and Wikipedia.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''Ferroptosis - Homo sapiens (human)''; https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa04216,

History

View all...
CompareRevisionActionTimeUserComment
107168view14:25, 17 September 2019MaintBotChEBI identifier normalization
106522view23:43, 5 September 2019KhanspersModified description
104979view19:13, 27 June 2019KhanspersModified description
101758view18:38, 5 November 2018Khanspersupdated xrefs for metabolites
97956view12:54, 26 June 2018EgonwAdded a title for the KEGG reference.
97955view12:51, 26 June 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97941view20:34, 25 June 2018Khanspersfixed lit ref
97940view20:34, 25 June 2018Khanspersedited lit ref
97939view20:32, 25 June 2018KhanspersAdded KEGG as lit ref
97938view20:31, 25 June 2018KhanspersModified description
97936view20:12, 25 June 2018KhanspersModified description
97935view20:12, 25 June 2018KhanspersAdded selenium and fixed incorrect reaction
97909view15:07, 23 June 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97908view19:33, 22 June 2018KhanspersModified description
97907view19:32, 22 June 2018KhanspersModified description
97906view19:29, 22 June 2018KhanspersOntology Term : 'cell death pathway' added !
97905view19:28, 22 June 2018KhanspersOntology Term : 'ferroptosis pathway' added !
97904view19:27, 22 June 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)-MevalonateMetaboliteCHEBI:17710 (ChEBI)
ACSL1GeneProductENSG00000151726 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
ACSL4GeneProductENSG00000068366 (Ensembl)
ACSL5GeneProductENSG00000197142 (Ensembl)
ACSL6GeneProductENSG00000164398 (Ensembl)
ALOX15GeneProductALOX15 (HGNC)
ATG5GeneProductENSG00000057663 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
ArachidonateMetaboliteCHEBI:15843 (ChEBI)
Arachidonyl-CoAMetaboliteCHEBI:15514 (ChEBI)
CPGeneProductENSG00000047457 (Ensembl)
CYBBGeneProductENSG00000165168 (Ensembl)
CoAMetaboliteCHEBI:15346 (ChEBI)
CoQ10MetaboliteCHEBI:46245 (ChEBI)
ErastinMetabolite11214940 (PubChem-compound)
FTH1GeneProductENSG00000167996 (Ensembl)
FTLGeneProductENSG00000087086 (Ensembl)
FTMTGeneProductENSG00000181867 (Ensembl)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
Fe3+MetaboliteCHEBI:29034 (ChEBI)
GCLCGeneProductENSG00000001084 (Ensembl)
GCLMGeneProductENSG00000023909 (Ensembl)
GPX4GeneProductENSG00000167468 (Ensembl)
GSSGeneProductENSG00000100983 (Ensembl)
GSSGMetaboliteCHEBI:17858 (ChEBI)
GlutathioneMetaboliteCHEBI:16856 (ChEBI)
HMG-CoAMetaboliteCHEBI:15467 (ChEBI)
HMOX1GeneProductENSG00000100292 (Ensembl)
IPPMetaboliteCHEBI:128769 (ChEBI)
LPCAT3GeneProductENSG00000111684 (Ensembl)
LysoPEMetaboliteCHEBI:75036 (ChEBI)
MAP1LC3AGeneProductENSG00000101460 (Ensembl)
MAP1LC3BGeneProductENSG00000140941 (Ensembl)
MAP1LC3CGeneProductENSG00000197769 (Ensembl)
NCOA4GeneProductENSG00000266412 (Ensembl)
PCBP1GeneProductENSG00000169564 (Ensembl)
PCBP2GeneProductENSG00000197111 (Ensembl)
PE-AA-O-OH/ PE-AdA-O-OHMetabolite124222235 (PubChem-compound)
PE-AA-OH/ PE-AdA-OHMetabolite52929784 (PubChem-compound)
PE-AA/ PE-AdAMetaboliteCHEBI:79110 (ChEBI)
PRNPGeneProductENSG00000171867 (Ensembl)
RSL3Metabolite1750826 (PubChem-compound)
SAT1GeneProductENSG00000130066 (Ensembl)
SAT2GeneProductENSG00000141504 (Ensembl)
SLC11A2GeneProductENSG00000110911 (Ensembl)
SLC39A14GeneProductENSG00000104635 (Ensembl)
SLC39A8GeneProductENSG00000138821 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC40A1GeneProductENSG00000138449 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
STEAP3GeneProductENSG00000115107 (Ensembl)
SeMetaboliteCHEBI:27568 (ChEBI)
SorafenibMetaboliteCHEBI:50924 (ChEBI)
SulfasalazineMetaboliteCHEBI:9334 (ChEBI)
TFGeneProductENSG00000091513 (Ensembl)
TFRCGeneProductENSG00000072274 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
Terpenoid backbone biosynthesisPathway
VDAC2GeneProductENSG00000165637 (Ensembl)
VDAC3GeneProductENSG00000078668 (Ensembl)
Vitamin EMetaboliteCHEBI:18145 (ChEBI)
cysteineMetaboliteCHEBI:15356 (ChEBI)
cystineMetaboliteCHEBI:35492 (ChEBI)
gamma-L-Glutamyl-L-cysteineMetaboliteCHEBI:17515 (ChEBI)
glutamateMetaboliteCHEBI:14321 (ChEBI)
hemeMetaboliteCHEBI:30413 (ChEBI)
hydrogen peroxideMetaboliteCHEBI:16240 (ChEBI)
hydroxyl radicalMetaboliteCHEBI:29191 (ChEBI)

Annotated Interactions

No annotated interactions

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