Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells (Homo sapiens)

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1MVBLateendosomeLegendESCRT-dependent pathwayEnhanced tumor growthChemoresistancePromotes EMTInhibited apoptosisProliferationManamycinRAB27AARAFMAPK1ALIXHNRNPH1BRAFRAF1RRASRRAS2MRASHRASKRASNRASMAPK3EarlyendosomeMVBRAB5ARAB5BRAB5CHGSRRASRRAS2MRASHRASKRASNRASALIXRAB27AESCRT-independent pathway


Schematic representation of inhibition of exosome biogenesis and secretion by Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and Rab27a. Description from Datta et al.

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  1. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB; ''Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.''; Cancer Lett, 2017 PubMed Europe PMC Scholia


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97800view19:10, 8 June 2018KhanspersOntology Term : 'Ras family mediated signaling pathway' added !
97652view20:43, 31 May 2018KhanspersModified title
97651view20:09, 31 May 2018KhanspersOntology Term : 'prostate cancer' added !
97650view20:08, 31 May 2018KhanspersModified description
97649view20:06, 31 May 2018KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ALIXGeneProductENSG00000170248 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
HGSGeneProductENSG00000185359 (Ensembl)
HNRNPH1GeneProductENSG00000169045 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MRASGeneProductENSG00000158186 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
RAB27AGeneProductENSG00000069974 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RRAS2GeneProductENSG00000133818 (Ensembl)
RRASGeneProductENSG00000126458 (Ensembl)

Annotated Interactions

No annotated interactions

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