Extracellular vesicles in the crosstalk of cardiac cells (Homo sapiens)

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1CardiomyocytePlasma EV'sMSC exosomeEVsFibroblastsEndothelial cellEVs in exerciseddiabetic miceHSPB1HSP90PDGFMIR455B. ApoptosisEGFCD63SORBS2FGFRenin angiotensinsystem (RAS)mir-19aVEGFR2mir-29b2HSP70SPP1GATA4PTENMAPK SignalingHSP20mir21-3pBIRC5NF-kB SignalingA. HypertrophyCD81TLR4C. FibrosisD. AngiogenesisSOD1MMP9STAT3IL6EVsEVsEGFREVsPDLIM5MIR320AEVsIGF1ETS2HSP20MSCmir-29b1p-Akt


(A) FB-derived exosomes enriched with miR-21-3p or Spp1 and EGFR proteins are transferred to CMs, leading to CM hypertrophy. (B) EVs secreted from CMs or MSCs, as well as circulating EVs exert regulatory effects on CM apoptosis. (C) CM-derived exosomal HSP90 together with secreted IL-6 are able to activate STAT-3 signaling in cardiac FBs, leading to cardiac fibrosis; whereas CM-derived exosomes from exercised diabetic mice express high levels of miR-29b and miR-455, thus reducing cardiac fibrosis. (D) EVs secreted from CMs or MSCs are transferred to ECs, exerting pro- or anti-angiogenic activities. Description from Bei et al.

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  1. Bei Y, Das S, Rodosthenous RS, Holvoet P, Vanhaverbeke M, Monteiro MC, Monteiro VVS, Radosinska J, Bartekova M, Jansen F, Li Q, Rajasingh J, Xiao J; ''Extracellular Vesicles in Cardiovascular Theranostics.''; Theranostics, 2017 PubMed Europe PMC Scholia


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105311view22:27, 29 July 2019AriuttaHGNC -> HGNC Accession number. Remove HGNC prefix.
97801view19:37, 8 June 2018Khanspersadded pathway node xrefs
97710view17:59, 6 June 2018Khanspersdecreased board height
97709view17:59, 6 June 2018Khanspersdecreased board height
97653view20:46, 31 May 2018KhanspersModified title
97648view19:27, 31 May 2018KhanspersModified description
97647view19:26, 31 May 2018Khansperslabels
97646view19:13, 31 May 2018KhanspersOntology Term : 'fibroblast of cardiac tissue' added !
97645view19:12, 31 May 2018KhanspersOntology Term : 'cardiac endothelial cell' added !
97644view19:12, 31 May 2018KhanspersOntology Term : 'cardiac muscle cell' added !
97643view19:11, 31 May 2018KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
A. HypertrophyPathwayWP516 (WikiPathways)
B. ApoptosisPathwayWP254 (WikiPathways)
BIRC5GeneProductENSG00000089685 (Ensembl)
C. FibrosisPathway
CD63GeneProductENSG00000135404 (Ensembl)
CD81GeneProductENSG00000110651 (Ensembl)
D. AngiogenesisPathwayWP1539 (WikiPathways)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ETS2GeneProductENSG00000157557 (Ensembl)
GATA4GeneProductENSG00000136574 (Ensembl)
HSP20GeneProductENSG00000142168 (Ensembl)
HSPB1GeneProductENSG00000106211 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MIR320AGeneProductENSG00000208037 (Ensembl)
MIR455GeneProductENSG00000207726 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NF-kB SignalingPathway
PDLIM5GeneProductENSG00000163110 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Renin angiotensin system (RAS)Pathway
SOD1GeneProductENSG00000142168 (Ensembl)
SORBS2GeneProductENSG00000154556 (Ensembl)
SPP1GeneProductENSG00000118785 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
VEGFR2GeneProductENSG00000128052 (Ensembl)
mir-19aGeneProduct406979 (Entrez Gene)
mir-29b1GeneProduct31619 (HGNC Accession number)
mir-29b2GeneProduct31620 (HGNC Accession number)
mir21-3pGeneProduct31586 (HGNC Accession number)

Annotated Interactions

No annotated interactions

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