Cell cycle (Rattus norvegicus)

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1G1proteolysis+pORC (OriginRecognition complex)DNA damage checkpointp21Securin+pGrowth Factor+p+uApoptosisDNADNA biosynthesisUbiquitin+u+pS-phase proteins+pS(Start)G2eTranscription Factor E2F-pCondensinemediatedpathway+ueHistone DeacetylaseseR-point-p+p+p+pe+p+uMp16,15,18,19+pMCM (Mini-ChromosomeMaintenance) complexDNA+u+pp27,57signaling+pHDACSeparin+p+p+pMAPKGrowth Factor withdrawal+p+pCcne2Mad2l1Pkmyt1E2FCdc20SCFHdac7Ccnb1Cdh1Rbl1E2f5MENTFDP1Ccna1Orc1lMcm6Chek1Smad4Skp2Cdk2Chek2Skp2Abl1Dbf4Espl1Cdc25cTp53Rb1Cdc2Cdc45lMad1l1Cdc14aCdkn2aSmad3E2F4Bub1bCcnb2APC/CPTTG3Cdc25bE2f1APC/CWee1Orc4lPttg1Ep300Tgfb1Gadd45aSmc1aGsk3bBUB3Hdac1Ccnd2Ccna2Cdc6MCMMAD2L2Ccna2GeneProductRb1AtmCdkn1aCcne1Cdk2Rb1Ccnb3PTTG2Cdc14bHdac8Ccnd3Cdc2Mcm5Mcm2Cdk2Cdkn1bMcm4Rbl114-3-3ORCOrc5lPlk1Cdk6E2f6Cdc7E2F2ARFHDAC5Mcm3SCFPrkdcCdk4PcnaE2f3Hdac3Orc6lUBE2FCcna1Bub1YwhagMdm2Mcm7Hdac4LOC680133Mpeg1ATRCcnhCdc25aHdac6Orc3lHdac2Orc2l


(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 81% conversion rate.

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Ontology Terms



  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia


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109404view17:38, 16 March 2020L DupuisFixed interactions
89530view11:04, 16 September 2016Mkutmonontology tag fix
89483view13:39, 15 September 2016Mkutmonremove space from ontology term id
71805view20:34, 17 October 2013MaintBotAutomated update of data sources
71308view17:00, 17 October 2013MaintBotAutomated update of data sources
69449view19:06, 8 July 2013MaintBotUpdated to 2013 gpml schema
67104view10:07, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62853view05:07, 3 May 2013MaintBotUpdated UniProt data source
41778view02:42, 2 March 2011MaintBotRemoved redundant pathway information and comments
35362view09:12, 12 February 2010MartijnVanIerselModified description
34146view19:35, 9 December 2009MaintBotAutomatic update of empty xrefs
32429view17:12, 15 August 2009MaintBotFixed text labels
32092view13:42, 14 August 2009MaintBotFixed group labels
31449view21:10, 13 August 2009MaintBotFixed text labels
31022view01:08, 30 July 2009MaintBotConverted from Homo sapiens
21584view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Cell cycle KEGG]] moved to [[Pathway:WP429]]: Moved to stable identifier
7952view13:46, 7 January 2008MaintBot[[Pathway:Rat:Cell cycle KEGG]] moved to [[Pathway:Rattus norvegicus:Cell cycle KEGG]]: Renaming species
7600view16:03, 18 December 2007MaintBotfixed category names
7208view12:33, 4 November 2007MaintBotAdded categories to GPML
19399view22:19, 22 May 2007BruceConklingpml file for [[Rat:Cell_cycle_KEGG]]
6524view22:19, 22 May 2007Nsalomonisgpml file for [[Rat:Cell_cycle_KEGG]]

External references


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NameTypeDatabase referenceComment
ATRGeneProduct300942 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
Abl1GeneProduct311860 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:
AtmGeneProduct300711 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:]
BUB3GeneProduct361662 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
Bub1GeneProduct296137 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
Bub1bGeneProduct171576 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Ccna1GeneProduct295052 (Entrez Gene) CCNA1; cyclin A1
Ccna2GeneProduct114494 (Entrez Gene) CCNA2; cyclin A2
Ccnb1GeneProduct25203 (Entrez Gene) CCNB1; cyclin B1
Ccnb2GeneProduct363088 (Entrez Gene) CCNB2; cyclin B2
Ccnb3GeneProduct317389 (Entrez Gene) CCNB3; cyclin B
Ccnd2GeneProduct64033 (Entrez Gene) CCND2; cyclin D2
Ccnd3GeneProduct25193 (Entrez Gene) CCND3; cyclin D3
Ccne1GeneProduct25729 (Entrez Gene) CCNE1; cyclin E
Ccne2GeneProduct362485 (Entrez Gene) CCNE2; cyclin E
CcnhGeneProduct84389 (Entrez Gene) CCNH; cyclin H
Cdc14aGeneProduct310806 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
Cdc14bGeneProduct361195 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
Cdc20GeneProduct64515 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
Cdc2GeneProduct54237 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
Cdc25aGeneProduct171102 (Entrez Gene) CDC25A; cell division cycle 25A [EC:]
Cdc25bGeneProduct171103 (Entrez Gene) CDC25B; cell division cycle 25B [EC:]
Cdc25cGeneProduct307511 (Entrez Gene) CDC25C; cell division cycle 25C [EC:]
Cdc45lGeneProduct287961 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
Cdc6GeneProduct360621 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
Cdc7GeneProduct360908 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
Cdh1GeneProduct83502 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
Cdk4GeneProduct94201 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
Cdk6GeneProduct114483 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
Cdkn1aGeneProduct114851 (Entrez Gene)
Cdkn1bGeneProduct83571 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
Cdkn2aGeneProduct25163 (Entrez Gene)
Chek1GeneProduct140583 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Chek2GeneProduct114212 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Dbf4GeneProduct312046 (Entrez Gene) ASK; activator of S phase kinas
E2F2GeneProductE2F2; E2F transcription factor 2
E2F4GeneProduct307794 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2f1GeneProduct399489 (Entrez Gene) E2F1; E2F transcription factor 1
E2f3GeneProduct291105 (Entrez Gene) E2F3; E2F transcription factor 3
E2f5GeneProduct116651 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2f6GeneProduct313978 (Entrez Gene) E2F6; E2F transcription factor 6
Ep300GeneProduct170915 (Entrez Gene) EP300; E1A binding protein p300
Espl1GeneProduct315330 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
Gadd45aGeneProduct25112 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:]
HDAC5GeneProduct84580 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac1GeneProduct297893 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct84577 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct84578 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct363287 (Entrez Gene) HDAC4; histone deacetylase 4
Hdac6GeneProduct84581 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7GeneProduct84582 (Entrez Gene) HDAC7A; histone deacetylase 7
Hdac8GeneProduct363481 (Entrez Gene) HDAC8; histone deacetylase
LOC680133GeneProduct680133 (Entrez Gene)
MAD2L2GeneProduct313702 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
Mad1l1GeneProduct680006 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
Mad2l1GeneProduct297176 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
Mcm2GeneProduct312538 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
Mcm3GeneProduct316273 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
Mcm4GeneProduct29728 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
Mcm5GeneProduct291885 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
Mcm6GeneProduct29685 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
Mcm7GeneProduct288532 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Mdm2GeneProduct314856 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
Mpeg1GeneProduct64552 (Entrez Gene)
Orc1lGeneProduct313479 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
Orc2lGeneProduct301430 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
Orc3lGeneProduct313138 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
Orc4lGeneProduct295596 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
Orc5lGeneProduct362304 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
Orc6lGeneProduct291927 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PTTG2GeneProduct360936 (Entrez Gene) PTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
PcnaGeneProduct25737 (Entrez Gene) PCNA; proliferating cell nuclear antigen
Pkmyt1GeneProduct287101 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
Plk1GeneProduct25515 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PrkdcGeneProduct360748 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:]
Pttg1GeneProduct64193 (Entrez Gene) PTTG1; pituitary tumor-transforming
Rb1GeneProduct24708 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
Rbl1GeneProduct680111 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
Skp2GeneProduct294790 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
Smad3GeneProduct25631 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
Smad4GeneProduct50554 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
Smc1aGeneProduct63996 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TFDP1GeneProductTFDP1; transcription factor Dp-1
Tgfb1GeneProduct59086 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)
UBE2FGeneProduct363284 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
Wee1GeneProduct308937 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:]
YwhagGeneProduct56010 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
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