Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (Homo sapiens)

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1LegendInactivating mutationIncreased tumor growth and motilityuc339(Entraper1)TP53MIR95MIR339MIR663BCCNE2Entrapping


The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.

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  1. Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M; ''Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.''; Nat Commun, 2017 PubMed Europe PMC Scholia


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108123view10:25, 29 November 2019FehrhartOntology Term : 'cancer' added !
105484view05:40, 8 August 2019KhanspersModified description
105456view05:07, 8 August 2019KhanspersModified description
97332view21:44, 9 May 2018KhanspersOntology Term : 'cancer pathway' added !
97331view21:43, 9 May 2018KhanspersOntology Term : 'microRNA pathway' added !
97330view21:43, 9 May 2018KhanspersModified description
97329view21:42, 9 May 2018KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
CCNE2GeneProductENSG00000175305 (Ensembl)
MIR339RnaENSG00000199023 (Ensembl)
MIR663BRnaENSG00000221288 (Ensembl)
MIR95RnaENSG00000207807 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
uc339 (Entraper1)GeneProduct

Annotated Interactions

No annotated interactions

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