AOP CYP2E1 Activation Leading To Neurodegeneration (Homo sapiens)

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1AO: Neurodegeneration (1514)StressorsIncrease concentration of ROSIncrease caspaseexpressionKE: Oxidative Stress (1510)Biomarker SBDP-145 increaseKE: Unfolded Protein Response (1512)MIE: CYP2E1 Activation (1508)KE: Apoptosis (1513)NFE2L2ERN1ApoptosischlorzoxazoneSOD1methoxyfluraneIsoniazidUnfolded Protein ResponseacetaminophenL(-)-Glutathione(oxidized)EIF2AK3titanium oxideBCL2ATF6CYP2E1 activationisofluraneSevofluraneOxidative StressTP53TG3CMAPK8ethanolAcetylcysteineHalothaneEnflurane


Description

CYP2E1 activation leading to neurodegeneration. This pathway is based on the Adverse Outcome Pathway by Jelle Broers on AOPWiki: https://aopwiki.org/aops/260 .

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Ontology Terms

 

Bibliography

  1. ''https://aopwiki.org/aops/260''; ,

History

CompareRevisionActionTimeUserComment
106790view13:27, 17 September 2019MaintBotHMDB identifier normalization
97425view14:18, 16 May 2018AdoBioInfoReplaced the textlabels with pathway nodes. Naisu.
97274view08:43, 7 May 2018AdoBioInfoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF6GeneProductENSG00000118217 (Ensembl)
AcetylcysteineMetaboliteCHEBI:17561 (ChEBI)
ApoptosisPathwayWP254 (WikiPathways)
BCL2GeneProductENSG00000171791 (Ensembl)
CYP2E1 activationPathwayWP4269 (WikiPathways)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
EnfluraneMetaboliteHMDB0014373 (HMDB)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
IsoniazidMetaboliteHMDB0015086 (HMDB)
L(-)-Glutathione(oxidized)MetaboliteCHEBI:17858 (ChEBI)
MAPK8GeneProductENSG00000107643 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
Oxidative StressPathwayWP408 (WikiPathways)
SOD1GeneProductENSG00000142168 (Ensembl)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
TP53TG3CGeneProductENSG00000205457 (Ensembl)
Unfolded Protein ResponsePathwayWP1939 (WikiPathways)
acetaminophenMetaboliteCHEBI:46195 (ChEBI)
chlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
isofluraneMetaboliteCHEBI:6015 (ChEBI)
methoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
titanium oxideMetaboliteCHEBI:134438 (ChEBI)

Annotated Interactions

No annotated interactions

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