Synthesis and Degradation of Ketone Bodies (Caenorhabditis elegans)

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1HMG-CoA cycle* pathway-regulated enzymes: HMG-CoA synthase, mtY71G12B.10HMGCS2Acetoacetate3-Hydroxy-butyrateBDH3-Hydroxy-3-methylglutaryl-CoAFatty Acid beta-oxidationC05C10.3kat-1Acetyl-CoAAcetyl-CoAAcetoacetyl-CoAPyruvate metabolismFatty acid metabolismSterol biosynthesisGlycolysis


Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia


GenMAPP notes 
Ketogenesis (Human)
GenMAPP remarks 
Adapted from KEGG

Quality Tags

Ontology Terms



  1. Fukao T, Lopaschuk GD, Mitchell GA; ''Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.''; Prostaglandins Leukot Essent Fatty Acids, 2004 PubMed Europe PMC


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84707view22:21, 15 March 2016Khanspersremoved problematic arcs, added pw nodes
84706view22:20, 15 March 2016KhanspersPeriodical save, work in progress
80064view09:38, 4 May 2015EgonwAdded two missing metabolite identifiers.
71012view19:18, 22 September 2013EgonwConverted Labels into DataNodes and connected dots.
68463view20:24, 5 July 2013MaintBotUpdated to 2013 gpml schema
67677view11:48, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
40619view19:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35373view09:16, 12 February 2010Thomasadded literature
35367view09:15, 12 February 2010ThomasModified description
21580view11:32, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:WP427]]: Moved to stable identifier
8579view14:03, 7 January 2008MaintBotAdded to category $category
8577view14:03, 7 January 2008N.ReyesUploaded new pathway

External references


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NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetaboliteCHEBI:11814 (ChEBI)
3-Hydroxy-butyrateMetaboliteCHEBI:37054 (ChEBI)
AcetoacetateMetaboliteCHEBI:13705 (ChEBI)
Acetoacetyl-CoAMetaboliteCHEBI:15345 (ChEBI)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
BDHGeneProduct (Entrez Gene)
C05C10.3GeneProduct174548 (Entrez Gene)
Fatty Acid beta-oxidationPathwayWP209 (WikiPathways)
Fatty acid metabolismPathway
GlycolysisPathwayWP96 (WikiPathways)
HMGCS2GeneProduct (Entrez Gene)
Pyruvate metabolismPathway
Sterol biosynthesisPathway
Y71G12B.10GeneProduct171738 (Entrez Gene)
kat-1GeneProduct174161 (Entrez Gene)

Annotated Interactions

No annotated interactions
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