Ethanol metabolism resulting in production of ROS by CYP2E1 (Homo sapiens)

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1AREPromoterSP600125NucleusPKCĪ¶ siRNAPPSIsiRNAROSEthanolNFE2L2MAP2K1MAFFMAFGDiallyl sulfideAcetaldehydeU0126CYP2E1CYP2E1Vitamin CStaurosporineSP1MAPK8MAP2K2Protein kinase CMAFKPSP1CYP2E1NFE2L2Stressors converted by CYP2E12-Difluoromethoxy-2,2-difluoroacetic acidFluorideEnfluraneHalothaneSevoflurane6-HydroxychlorzoxazoneIsofluraneNAPQIMethoxyfluraneAcetaminophenChlorzoxazoneTrifluoroacetic acidSubstrateOutcome metaboliteFluorideFluoride


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and mouse.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106788view13:26, 17 September 2019MaintBotHMDB identifier normalization
104897view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98054view06:02, 13 July 2018Fehrhartfixed greek character
98053view06:00, 13 July 2018Fehrhartlayout
97869view12:01, 12 June 2018Marvin M2Modified description
97427view14:26, 16 May 2018AdoBioInfoHomo sapiens pathway was missing the list with substrates, woops.
97426view14:21, 16 May 2018AdoBioInfoAdded a sweet elbow arrow to fix an unconnected line. And added a reference, because y'all love references.
97154view08:04, 2 May 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97142view11:56, 1 May 2018AdoBioInfoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
6-HydroxychlorzoxazoneMetaboliteHMDB0060998 (HMDB)
AcetaldehydeMetaboliteCHEBI:15343 (ChEBI)
AcetaminophenMetaboliteCHEBI:46195 (ChEBI)
CYP2E1GeneProductENSG00000130649 (Ensembl)
ChlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB0014373 (HMDB)
EthanolMetaboliteCHEBI:16236 (ChEBI)
FluorideMetaboliteCHEBI:17051 (ChEBI)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
IsofluraneMetaboliteCHEBI:6015 (ChEBI)
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
MAFKGeneProductENSG00000198517 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MethoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
NFE2L2GeneProductENSG00000116044 (Ensembl)
Protein kinase CProteinA0A087X0I9 (Uniprot-TrEMBL)
SP1GeneProductENSG00000185591 (Ensembl)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
StaurosporineMetaboliteCHEBI:57491 (ChEBI)
Trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)
U0126MetaboliteCHEBI:90693 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)

Annotated Interactions

No annotated interactions

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