lncRNA in canonical Wnt signaling and colorectal cancer (Homo sapiens)

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ScaffoldAPC21LegendNucleusTranscriptional ActivationCytoplasmActivating mutationProliferationMigration, invasionStem cell maintenanceWnt target genesEZH226S Proteasome DegradationPLAUCCND3AXIN1DVL3H2AFY2WNT2MAP3K7HNRNPKATF3WNT11CSNK2A2CCALCSNK1A1LRUVBL1FZD7MIR34AWNT10BCSNK2BWNT16DVL1CSNK1A1WNT1FZD9MYCFZD8WNT5AROR1TCF3WNT4GSK3BRYKCTNNB1CSNK2A1CSNK2A3WNT16WNT3AWNT6FZD5FZD4FZD1FRAT1LRP5CSNK1EJUNFZD2CHD8FOSL1CDK8MAPK SignalingDVL2APCCCND1CCND2lnc34AFZD6TCF7L2TFAP2AWNT2BFZD10RBM5-AS1TCF7L1WNT7BKREM1LRP6Cell cycle progressionWNT7AWNT10ALEF1WNT5BTCF7WNT3CDK6FZD3PPROR2PPPPPCTNNB1DKK1DKK2DKK4SOSTSERPINF1FRAT2CTNNB1SFRP1SFRP2SFRP4SFRP5NOTUMCER1WIF1PORCNNKD1NKD2CXXC4SENP2NLKPCTNNBIP1SOX17CTBP1CTBP2MIR16-2MIR16-1MYUH19NKD1HNRNPUH19H19ASBELInactivating mutationlncRNAmiRNAAXIN2


Description

Long non-coding RNAs (lncRNAs) have emerged as significant players in colorectal cancer pathogenesis. This pathway represents a review of long non-coding RNA (LncRNA) involvement in canonical Wnt signaling as it relates to colorectal cancer. The pathway is adapted from Shen et al .

Quality Tags

Ontology Terms

 

Bibliography

  1. Shen P, Pichler M, Chen M, Calin GA, Ling H; ''To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer.''; Int J Mol Sci, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123417view06:11, 26 July 2022EgonwMade three pathways clickable
117770view13:31, 22 May 2021EweitzModified title
108136view10:32, 29 November 2019FehrhartOntology Term : 'colorectal cancer' added !
108135view10:31, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106508view20:40, 5 September 2019KhanspersModified description
105487view05:44, 8 August 2019KhanspersModified description
105471view05:18, 8 August 2019KhanspersModified description
97136view21:42, 30 April 2018Khanspersconnected missing interaction
96917view15:43, 19 April 2018Khanspersfixed broken interaction
96905view19:14, 18 April 2018KhanspersModified description
96904view18:52, 18 April 2018Khanspersfixed broken interaction
96890view05:35, 18 April 2018KhanspersModified description
96889view05:34, 18 April 2018Khansperschanged scaffold location
96888view05:33, 18 April 2018KhanspersOntology Term : 'disease pathway' added !
96887view05:33, 18 April 2018KhanspersOntology Term : 'Wnt signaling, canonical pathway' added !
96886view05:32, 18 April 2018KhanspersOntology Term : 'colorectal cancer pathway' added !
96885view05:31, 18 April 2018KhanspersModified title
96884view05:31, 18 April 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProduct324 (Entrez Gene)
ASBELGeneProduct
ATF3GeneProductENSG00000162772 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProductENSG00000168646 (Ensembl)
CCALGeneProduct
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CDK6GeneProductENSG00000105810 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProductENSG00000178585 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
Cell cycle progressionPathwayWP179 (WikiPathways)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EZH2GeneProductENSG00000106462 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
H19GeneProductENSG00000130600 (Ensembl)
H2AFY2GeneProductENSG00000099284 (Ensembl)
HNRNPKGeneProductENSG00000165119 (Ensembl)
HNRNPUGeneProductENSG00000153187 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KREM1GeneProduct83999 (Entrez Gene)
LEF1GeneProductENSG00000138795 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR16-2GeneProductENSG00000198987 (Ensembl)
MIR34AGeneProductENSG00000228526 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
MYUGeneProduct
NKD1GeneProductENSG00000140807 (Ensembl)
NKD2GeneProductENSG00000145506 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
PLAUGeneProduct5328 (Entrez Gene)
PORCNGeneProductENSG00000102312 (Ensembl)
RBM5-AS1GeneProduct
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RUVBL1GeneProductENSG00000175792 (Ensembl)
RYKGeneProduct6259 (Entrez Gene)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
TCF3GeneProductENSG00000071564 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
lnc34AGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://www.wikipathways.org/index.php/Pathway:WP4258"
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