Type 2 papillary renal cell carcinoma (Homo sapiens)

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2-511Epithelial cell of proximal renal tubuleNucleusMitochondrionGene fusionsOther genes of interestDegradationNormoxiaoxygenFHFumarateSETD2TGFb Signaling PathwayVEGF SignalingCitrate CycleEPAS1TFE3PRCCCDKN1ATFE3SFPQTFE3DVL2CTSKBIRC7DIAPH1HIF1ACTSKTFEBTFEBCOL21A1CADM2HIF1AL-malateEGLN1EGLN2EGLN3HypoxiaPseudohypoxiaELOCELOBVHLRBX1CUL2UbiquitinationARNTARNT2CREBBPEP300SLC2A1VEGFATGFB1TGFB2TGFB3PDGFBTGFAGlucose transportAngiogenesisAutocrine growth stimulationIncreased nutrientsand oxygenCell proliferationLegendActivating mutationInactivating mutation


Description

Based on KEGG: http://www.genome.jp/kegg-bin/show_pathway?hsa05211

Renal cell carcinoma (RCC), the most common form of kidney cancer in adults, is not a single disease but rather a collection of different tumor types driven by distinct genetic changes that arise within the same tissue. Papillary RCC represents 15 to 20 percent of RCC diagnoses and can manifest as an aggressive, solitary tumor or as multiple, slow-growing tumors. Papillary RCC itself has two main subtypes, type 1 and type 2, that are distinguished histologically. Little is currently known about the genetic basis of non-hereditary papillary RCC and patients receive treatment simply based on disease stage. If caught early, the disease can usually be cured surgically. From https://ccr.cancer.gov/news/article/understanding-papillary-renal-cell-carcinoma

Quality Tags

Ontology Terms

 

Bibliography

  1. Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R; ''Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.''; N Engl J Med, 2016 PubMed
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  5. Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG; ''The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.''; Exp Cell Res, 2009 PubMed

History

View all...
CompareRevisionActionTimeUserComment
97131view19:37, 30 April 2018Khansperstried removing erroneous lit ref
97128view18:30, 30 April 2018KhanspersModified description
97127view18:23, 30 April 2018KhanspersOntology Term : 'papillary renal cell carcinoma' added !
97124view18:11, 30 April 2018Khanspersupdated lit refs, connected interactions
96865view00:50, 15 April 2018AlexanderPicoOntology Term : 'disease pathway' added !
96631view19:31, 23 March 2018KhanspersModified description
96630view19:30, 23 March 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARNT2GeneProductENSG00000172379 (Ensembl)
ARNTGeneProductENSG00000143437 (Ensembl)
BIRC7GeneProductENSG00000101197 (Ensembl)
CADM2GeneProductENSG00000175161 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
COL21A1GeneProductENSG00000124749 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTSKGeneProductENSG00000143387 (Ensembl)
CUL2GeneProductENSG00000108094 (Ensembl)
Citrate CyclePathwayWP78 (WikiPathways)
DIAPH1GeneProductENSG00000131504 (Ensembl)
DVL2GeneProductENSG00000004975 (Ensembl)
EGLN1GeneProductENSG00000135766 (Ensembl)
EGLN2GeneProductENSG00000269858 (Ensembl)
EGLN3GeneProductENSG00000129521 (Ensembl)
ELOBGeneProductENSG00000103363 (Ensembl)
ELOCGeneProductENSG00000154582 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
EPAS1GeneProductENSG00000116016 (Ensembl)
FHGeneProductENSG00000091483 (Ensembl)
FumarateMetaboliteCHEBI:18012 (ChEBI)
HIF1AGeneProductENSG00000100644 (Ensembl)
L-malateMetaboliteCHEBI:15589 (ChEBI)
PDGFBGeneProductENSG00000100311 (Ensembl)
PRCCGeneProductENSG00000143294 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SFPQGeneProductENSG00000116560 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
TFE3GeneProductENSG00000068323 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFb Signaling PathwayPathwayWP560 (WikiPathways)
VEGF SignalingPathwayWP3888 (WikiPathways)
VEGFAGeneProductENSG00000112715 (Ensembl)
VHLGeneProductENSG00000134086 (Ensembl)
oxygenMetaboliteCHEBI:25805 (ChEBI)

Annotated Interactions

No annotated interactions

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