Biosynthesis of gamma-Aminobutyric Acid (GABA) by Polyamine Oxidation (Arabidopsis thaliana)

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In plants, polyamines are oxidatively deaminated by copper- and flavin-containing odixases (CuAO and PAO) leading to the generation of H2O2 and 4-aminobutanal (ABAL) which can be converted to 4-aminobutyric acid (GABA). A well known neurotransmitter in animals, GABA plays a role in stress response in plants.

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Ontology Terms



  1. Planas-Portell J, Gallart M, Tiburcio AF, Altabella T; ''Copper-containing amine oxidases contribute to terminal polyamine oxidation in peroxisomes and apoplast of Arabidopsis thaliana.''; BMC Plant Biol, 2013 PubMed Europe PMC Scholia
  2. Zarei A, Trobacher CP, Shelp BJ; ''Arabidopsis aldehyde dehydrogenase 10 family members confer salt tolerance through putrescine-derived 4-aminobutyrate (GABA) production.''; Sci Rep, 2016 PubMed Europe PMC Scholia
  3. Bitrián M, Zarza X, Altabella T, Tiburcio AF, Alcázar R; ''Polyamines under Abiotic Stress: Metabolic Crossroads and Hormonal Crosstalks in Plants.''; Metabolites, 2012 PubMed Europe PMC Scholia


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96609view12:20, 23 March 2018DeSlOntology Term : 'amino acid neurotransmitter metabolic pathway' added !
96527view08:51, 17 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96518view22:44, 16 March 2018AlexanderPicoOntology Term : 'classic metabolic pathway' added !
96517view22:44, 16 March 2018AlexanderPicoOntology Term : 'polyamine metabolic pathway' added !
96516view22:44, 16 March 2018AlexanderPicoOntology Term : 'putrescine metabolic pathway' added !
96515view22:44, 16 March 2018AlexanderPicoOntology Term : 'gamma-aminobutyric acid metabolic pathway' added !
96514view22:43, 16 March 2018AlexanderPicoNew pathway

External references


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NameTypeDatabase referenceComment
ABALMetaboliteCHEBI:17769 (ChEBI)
ALDH10A8GeneProduct843831 (Entrez Gene)
ALDH10A9GeneProduct823972 (Entrez Gene)
CuAO1GeneProduct842580 (Entrez Gene)
CuAO2GeneProduct818849 (Entrez Gene)
CuAO3GeneProduct840058 (Entrez Gene)
GABAMetaboliteCHEBI:16865 (ChEBI)
PAO2GeneProduct818904 (Entrez Gene)
PAO3GeneProduct825074 (Entrez Gene)
PAO4GeneProduct842894 (Entrez Gene)
PutrescineMetaboliteCHEBI:17148 (ChEBI)
SpermineMetaboliteCHEBI:15746 (ChEBI)
spermidineMetaboliteCHEBI:57834 (ChEBI)

Annotated Interactions

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