Insulin induced PI3K-Akt and MAPK in hepatocytes (Rattus norvegicus)

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1Glycolysis &Glycogen synthesisInsulin-1Grb10IRS2mLST8BADAclyERKSOS1Foxo1Gys1SHC-1RASEif4eAkt1s1IRS1S6KMEKGys2TSC1FoxK1LARP1Pi3KAktRhebGsk3RSK1Raptor4eBPPfkfb2RAFTSC2mTORNdrg1Rps6GRB2Fatty acid synthesisGrowth &DifferentiationCell size, growth &Protein synthesis


Description

Insulin-induced P13K-Akt and MAPK network in hepatocytes. Pathway is adapted from Figure 5 in the publication by Zhang et al (2017) in the Journal of Proteome Research

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Ontology Terms

 

Bibliography

  1. Zhang Y, Yu Y; ''Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes.''; J Proteome Res, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
96564view10:16, 19 March 2018SusanOntology Term : 'hepatocyte' added !
96563view10:16, 19 March 2018SusanOntology Term : 'insulin signaling pathway' added !
96334view11:19, 8 March 2018SusanChanged arrow
96333view11:17, 8 March 2018SusanAdded Insulin
96332view11:08, 8 March 2018SusanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
4eBPGeneProductENSRNOG00000012582 (Ensembl)
AclyGeneProductENSRNOG00000016924 (Ensembl)
Akt1s1GeneProductENSRNOG00000020289 (Ensembl)
AktGeneProductENSRNOG00000028629 (Ensembl)
BADGeneProductENSRNOG00000021147 (Ensembl)
ERKGeneProductENSRNOG00000001849 (Ensembl)
Eif4eGeneProductENSRNOG00000052343 (Ensembl)
FoxK1GeneProductENSRNOG00000001104 (Ensembl)
Foxo1GeneProductENSRNOG00000013397 (Ensembl)
GRB2GeneProductENSRNOG00000003990 (Ensembl)
Grb10GeneProductENSRNOG00000004290 (Ensembl)
Gsk3GeneProductENSRNOG00000020417 (Ensembl)
Gys1GeneProductENSRNOG00000020812 (Ensembl)
Gys2GeneProductENSRNOG00000059753 (Ensembl)
IRS1GeneProductENSRNOG00000014597 (Ensembl)
IRS2GeneProductENSRNOG00000023509 (Ensembl)
Insulin-1ProteinP01322 (Uniprot-TrEMBL)
LARP1GeneProductENSRNOG00000031544 (Ensembl)
MEKGeneProductENSRNOG00000053583 (Ensembl)
Ndrg1GeneProductENSRNOG00000007393 (Ensembl)
Pfkfb2GeneProductENSRNOG00000004162 (Ensembl)
Pi3KGeneProductENSRNOG00000017840 (Ensembl)
RAFGeneProductENSRNOG00000010153 (Ensembl)
RASGeneProductENSRNOG00000009338 (Ensembl)
RSK1GeneProductENSRNOG00000042411 (Ensembl)
RaptorGeneProductENSRNOG00000003821 (Ensembl)
RhebGeneProductENSRNOG00000050578 (Ensembl)
Rps6GeneProductENSRNOG00000007663 (Ensembl)
S6KGeneProductENSRNOG00000003919 (Ensembl)
SHC-1GeneProductENSRNOG00000020657 (Ensembl)
SOS1GeneProductENSRNOG00000007106 (Ensembl)
TSC1GeneProductENSRNOG00000011470 (Ensembl)
TSC2GeneProductENSRNOG00000011375 (Ensembl)
mLST8GeneProductENSRNOG00000009667 (Ensembl)
mTORGeneProductENSRNOG00000009615 (Ensembl)

Annotated Interactions

No annotated interactions

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