Mevalonate arm of cholesterol biosynthesis pathway (Homo sapiens)

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1CytosolmitochondriaTransportEndoplasmic reticulumPeroxisomeacetoacetateACAT1FDPSHMGCRHMGCS1dimethylallyl-PP3-hydroxy-3-methylglutaryl-CoAMitochondrial beta-oxidation of fatty acidscholesterol synthesisMVKacetoacetyl-CoAHMGCLAcetyl-CoAIDI1FDFT1mevaldyl-CoAmevalonatemevalonate-Pmevalonate-PPisopenthyl-PPPMVKMVDgeranyl-PPfamesyl-PPgeranylgeranyl-PPpresqualene-PPsqualeneprotein prenylationGGPS1IDI2GGPS1famesyl-PP3-hydroxy-3-methylglutaryl-CoAmevalonateHMGCRAcetyl-CoAacetoacetyl-CoA3-hydroxy-3-methylglutaryl-CoAAcetyl-CoAacetoacetyl-CoAACAT1acetoacetateHMGCLMitochondrial beta-oxidation of fatty acidsACAT2HMGCS1


Description

The mevalonate arm of the cholesterol biosynthesis pathway within different cellular regions. View more details on which drugs are related to these reactions at [1]. View the broader scope of cholesterol metabolism at [2].

Quality Tags

Ontology Terms

 

Bibliography

  1. Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P; ''A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.''; Biochem Pharmacol, 2013 PubMed
  2. Greenspan MD, Yudkovitz JB, Lo CY, Chen JS, Alberts AW, Hunt VM, Chang MN, Yang SS, Thompson KL, Chiang YC; ''Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.''; Proc Natl Acad Sci U S A, 1987 PubMed

History

View all...
CompareRevisionActionTimeUserComment
101730view12:37, 2 November 2018DeSlModified description
101729view12:36, 2 November 2018DeSlModified description
97482view12:50, 23 May 2018Fehrhartfixed connection
96455view11:45, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95421view13:41, 14 December 2017DeSlOntology Term : 'metabolising cell' added !
95420view13:40, 14 December 2017DeSlOntology Term : 'cell' added !
95419view13:39, 14 December 2017DeSlOntology Term : 'mitochondria transport pathway' added !
95418view13:08, 14 December 2017DeSlOntology Term : 'cholesterol biosynthetic pathway' added !
95417view13:07, 14 December 2017DeSlAdded wikidata as database source where applicable
95416view13:00, 14 December 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-hydroxy-3-methylglutaryl-CoAMetaboliteQ27108899 (Wikidata)
ACAT1ProteinQ4650507 (Wikidata)
ACAT2ProteinQ21119315 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
FDFT1ProteinQ21108578 (Wikidata)
FDPSProteinQ21107439 (Wikidata)
GGPS1ProteinQ21106540 (Wikidata)
HMGCLProteinQ21118307 (Wikidata)
HMGCRProtein1.1.1.88 (Enzyme Nomenclature)
HMGCS1ProteinQ21118293 (Wikidata)
IDI1ProteinQ21151146 (Wikidata)
IDI2ProteinQ21132842 (Wikidata)
MVDProtein4.1.1.33 (Enzyme Nomenclature)
MVKProteinQ424031 (Wikidata)
Mitochondrial

beta-oxidation of

fatty acids
Pathway
PMVKProteinQ22676988 (Wikidata)
acetoacetateMetaboliteQ21559339 (Wikidata)
acetoacetyl-CoAMetaboliteQ2639429 (Wikidata)
cholesterol synthesisPathwayWP197 (WikiPathways)
dimethylallyl-PPMetaboliteQ417398 (Wikidata)
famesyl-PPMetaboliteQ45416123 (Wikidata)
geranyl-PPMetaboliteQ418125 (Wikidata)
geranylgeranyl-PPMetaboliteQ774795 (Wikidata)
isopenthyl-PPMetaboliteQ417403 (Wikidata)
mevaldyl-CoAMetabolite
mevalonate-PPMetaboliteQ45415198 (Wikidata)
mevalonate-PMetaboliteQ45414671 (Wikidata)
mevalonateMetaboliteQ27109878 (Wikidata)
presqualene-PPMetaboliteQ27088444 (Wikidata)
protein prenylationPathway
squaleneMetaboliteQ407560 (Wikidata)

Annotated Interactions

No annotated interactions

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