Mevalonate arm of cholesterol biosynthesis pathway (Homo sapiens)

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1CytosolTransportmitochondriaPeroxisomeEndoplasmic reticulumacetoacetyl-CoAMVKHMGCLAcetyl-CoAdimethylallyl-PPIDI1ACAT1HMGCR3-hydroxy-3-methylglutaryl-CoAFDPSHMGCS1cholesterol synthesisFDFT1acetoacetateMitochondrial beta-oxidation of fatty acidsmevaldyl-CoAmevalonatemevalonate-Pmevalonate-PPisopenthyl-PPPMVKMVDgeranyl-PPfamesyl-PPgeranylgeranyl-PPpresqualene-PPsqualeneprotein prenylationGGPS1IDI2GGPS1famesyl-PP3-hydroxy-3-methylglutaryl-CoAmevalonateHMGCRAcetyl-CoAacetoacetyl-CoA3-hydroxy-3-methylglutaryl-CoAAcetyl-CoAacetoacetyl-CoAACAT1acetoacetateHMGCLMitochondrial beta-oxidation of fatty acidsACAT2HMGCS1


Description

The mevalonate arm of the cholesterol biosynthesis pathway within different cellular regions

Quality Tags

Ontology Terms

 

Bibliography

  1. Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P; ''A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.''; Biochem Pharmacol, 2013 PubMed
  2. Greenspan MD, Yudkovitz JB, Lo CY, Chen JS, Alberts AW, Hunt VM, Chang MN, Yang SS, Thompson KL, Chiang YC; ''Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.''; Proc Natl Acad Sci U S A, 1987 PubMed

History

View all...
CompareRevisionActionTimeUserComment
97482view12:50, 23 May 2018Fehrhartfixed connection
96455view11:45, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95421view13:41, 14 December 2017DeSlOntology Term : 'metabolising cell' added !
95420view13:40, 14 December 2017DeSlOntology Term : 'cell' added !
95419view13:39, 14 December 2017DeSlOntology Term : 'mitochondria transport pathway' added !
95418view13:08, 14 December 2017DeSlOntology Term : 'cholesterol biosynthetic pathway' added !
95417view13:07, 14 December 2017DeSlAdded wikidata as database source where applicable
95416view13:00, 14 December 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-hydroxy-3-methylglutaryl-CoAMetaboliteQ27108899 (Wikidata)
ACAT1ProteinQ4650507 (Wikidata)
ACAT2ProteinQ21119315 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
FDFT1ProteinQ21108578 (Wikidata)
FDPSProteinQ21107439 (Wikidata)
GGPS1ProteinQ21106540 (Wikidata)
HMGCLProteinQ21118307 (Wikidata)
HMGCRProtein1.1.1.88 (Enzyme Nomenclature)
HMGCS1ProteinQ21118293 (Wikidata)
IDI1ProteinQ21151146 (Wikidata)
IDI2ProteinQ21132842 (Wikidata)
MVDProtein4.1.1.33 (Enzyme Nomenclature)
MVKProteinQ424031 (Wikidata)
Mitochondrial

beta-oxidation of

fatty acids
Pathway
PMVKProteinQ22676988 (Wikidata)
acetoacetateMetaboliteQ21559339 (Wikidata)
acetoacetyl-CoAMetaboliteQ2639429 (Wikidata)
cholesterol synthesisPathwayWP197 (WikiPathways)
dimethylallyl-PPMetaboliteQ417398 (Wikidata)
famesyl-PPMetaboliteQ45416123 (Wikidata)
geranyl-PPMetaboliteQ418125 (Wikidata)
geranylgeranyl-PPMetaboliteQ774795 (Wikidata)
isopenthyl-PPMetaboliteQ417403 (Wikidata)
mevaldyl-CoAMetabolite
mevalonate-PPMetaboliteQ45415198 (Wikidata)
mevalonate-PMetaboliteQ45414671 (Wikidata)
mevalonateMetaboliteQ27109878 (Wikidata)
presqualene-PPMetaboliteQ27088444 (Wikidata)
protein prenylationPathway
squaleneMetaboliteQ407560 (Wikidata)

Annotated Interactions

No annotated interactions

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