Mitochondrial LC-Fatty Acid Beta-Oxidation (Rattus norvegicus)

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mitochondrial matrixLong-chain saturated fatty acidssaturatedcytosolunsaturatedAcyl-CoA dehydrogenases:2,4 Dienoyl-CoAAcadvlAcadmAcadsAcsl3Long chain acyl-carnitine3-L-Hydroxyacyl-CoACpt2ACSL2HadhaAcsl1Long chain Acyl-CoAHadhSlc25a20Acsl4Cpt1aL-CarnitineAcadlPalmitic acidScp2Acyl-CoA (n-2)trans-D2-Enoyl-CoADcicis-D3-Enoyl-CoA3-Ketoacyl-CoAEhhadhPecrArachidic acidLong chain Acyl-CoALong chain acyl-carnitineAcetyl-CoAStearic acidLong-chain unsaturated fatty acidsPalmitoleic acidOleic acidL-Carnitine


Beta-oxidation is the process by which fatty acid molecules are broken down in the mitochondria to generate acetyl-coA,which enters the citric acid cycle, and NADH, FADH2 to be used by the electron transport chain. Source: Wikipedia (


This pathway was inferred from Homo sapiens pathway WP368(r21451) with a 89% conversion rate.

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Ontology Terms



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109390view15:58, 16 March 2020L DupuisFixed interactions
107243view14:34, 17 September 2019MaintBotChEBI identifier normalization
106991view13:45, 17 September 2019MaintBotHMDB identifier normalization
71803view20:34, 17 October 2013MaintBotAutomated update of data sources
69434view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67482view11:07, 26 June 2013DdiglesOntology Term : 'fatty acid beta degradation pathway' added !
60486view14:49, 20 March 2013Cizarannotated acetyl-CoA
60018view17:18, 12 March 2013KhanspersModified description
60017view17:16, 12 March 2013Khanspersremoved genmapp comments
60016view17:15, 12 March 2013KhanspersModified description
59962view15:57, 11 March 2013SusanAdd carnitine AND fatty acids
59957view15:34, 11 March 2013SusanPeriodical save, work in progress
59956view15:23, 11 March 2013SusanPeriodical save, work in progress
47762view05:10, 6 April 2012Khanspersupdated xrefs
41759view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34129view19:29, 9 December 2009MaintBotAutomatic update of empty xrefs
32088view13:41, 14 August 2009MaintBotFixed group labels
30936view00:39, 30 July 2009MaintBotConverted from Homo sapiens
21564view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Mitochondrial fatty acid betaoxidation]] moved to [[Pathway:WP419]]: Moved to stable identifier
8264view13:46, 7 January 2008MaintBot[[Pathway:Rat:Mitochondrial fatty acid betaoxidation]] moved to [[Pathway:Rattus norvegicus:Mitochondrial fatty acid betaoxidation]]: Renaming species
7752view16:15, 18 December 2007MaintBotfixed category names
7380view12:42, 4 November 2007MaintBotAdded categories to GPML
6576view22:20, 22 May 2007N.Reyesgpml file for [[Rat:Mitochondrial_fatty_acid_betaoxidation]]

External references


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NameTypeDatabase referenceComment
2,4 Dienoyl-CoAMetaboliteType your comment here
AcadlGeneProduct25287 (Entrez Gene)
AcadmGeneProduct24158 (Entrez Gene)
AcadsGeneProduct64304 (Entrez Gene)
AcadvlGeneProduct25363 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Acsl1GeneProduct25288 (Entrez Gene)
Acsl3GeneProduct114024 (Entrez Gene)
Acsl4GeneProduct113976 (Entrez Gene)
Acyl-CoA (n-2)Metabolite
Arachidic acidMetaboliteHMDB0002212 (HMDB)
Cpt1aGeneProduct25757 (Entrez Gene)
Cpt2GeneProduct25413 (Entrez Gene)
DciGeneProduct29740 (Entrez Gene)
EhhadhGeneProduct171142 (Entrez Gene)
HadhGeneProduct113965 (Entrez Gene)
HadhaGeneProduct170670 (Entrez Gene) similiar to: ECHA RAT
L-CarnitineMetaboliteHMDB0000062 (HMDB)
Long chain Acyl-CoAMetabolite
Long chain acyl-carnitineMetabolite
Oleic acidMetaboliteHMDB0000207 (HMDB)
Palmitic acidMetaboliteHMDB0000220 (HMDB)
Palmitoleic acidMetaboliteHMDB0003229 (HMDB)
PecrGeneProduct113956 (Entrez Gene)
Scp2GeneProduct25541 (Entrez Gene)
Slc25a20GeneProduct117035 (Entrez Gene)
Stearic acidMetaboliteHMDB0000827 (HMDB)
trans-D2-Enoyl-CoAMetaboliteCHEBI:10723 (ChEBI)

Annotated Interactions

No annotated interactions
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