Mevalonate arm of cholesterol biosynthesis pathway with inhibitors (Homo sapiens)

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12farnesyl thiodiphosphateHMGCRAcetyl-CoA3-hydroxy-3-methylglutaryl-CoAL-659699MVK6-fluoromevalonate 5-diphosphatecholesterol synthesis2-fluoromevalonate 5-diphosphatedimethylallyl-PPCinnamic acidBPH-628HMGCS1(+)-Zaragozic acidIDI1rosuvastatinzoledronic acidFDPSacetoacetyl-CoAFDFT1mevaldyl-CoAmevalonatemevalonate-Pmevalonate-PPisopenthyl-PPPMVKMVDgeranyl-PPfamesyl-PPgeranylgeranyl-PPpresqualene-PPsqualeneprotein prenylationGGPS1IDI2GGPS1cerivastatinatorvastatinlovastatinsimvastatinCHEMBL39312CHEMBL39102Fluvastatin3-hydroxy-3-methyl-6-phosphohexanoic acidisoferulic acidp-coumaric aciddiphosphoglycolyl prolineCHEMBL1160330CHEMBL1160328P'-geranyl 2-fluoromevalonate 5-diphosphateP′-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphateNE97220RisedronateNE58062NE58018BPH-608BPH-675BPH-629BPH-676BPH-628BPH-608BPH-675BPH-629BPH-676BPH-830CHEMBL24362sq-109CHEMBL1208103[1-(Hydroxycarbamoyl)-4-(3-phenoxyphenyl)butyl]phosphonateCHEMBL1207858Compound 13 (1-Methyl-1-{[3-(3-phenoxyphenyl)propyl]carbamoyl}ethyl)phosphonate


Description

An analysis of the mevalonate branch of the cholesterol biosynthesis pathway, and a set of inhibitors directed against targets in this pathway. Inhibitors which have been found for Homo Sapiens are coloured red, those found for Rattus norvegicus orange. View more details on where these reactions in the cell take place at [1]. View the broader scope of cholesterol metabolism at [2].

Quality Tags

Ontology Terms

 

Bibliography

  1. Benson HE, Watterson S, Sharman JL, Mpamhanga CP, Parton A, Southan C, Harmar AJ, Ghazal P; ''Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.''; Br J Pharmacol, 2017 PubMed
  2. Greenspan MD, Yudkovitz JB, Lo CY, Chen JS, Alberts AW, Hunt VM, Chang MN, Yang SS, Thompson KL, Chiang YC; ''Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.''; Proc Natl Acad Sci U S A, 1987 PubMed

History

View all...
CompareRevisionActionTimeUserComment
101731view12:37, 2 November 2018DeSlModified description
101728view12:35, 2 November 2018DeSlModified description
98185view14:59, 2 August 2018DeSlAdded chembl compound prefix for IDs.
97916view16:46, 23 June 2018EgonwFixed a data source.
97507view13:37, 24 May 2018Jessev1993Changed annotation from enzyme nomenclature to Uniprot annotion
96454view11:41, 15 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
95821view13:41, 22 January 2018DeSlConnected unconnected line
95415view12:20, 14 December 2017DeSlchanged misspelled node.
95414view12:18, 14 December 2017DeSlOntology Term : 'cholesterol biosynthetic pathway' added !
95413view12:18, 14 December 2017DeSlOntology Term : 'altered cholesterol biosynthetic pathway' added !
95412view12:13, 14 December 2017DeSlAdded wikidata as database source where applicable
95411view12:09, 14 December 2017DeSlModified description
95410view12:07, 14 December 2017DeSlAdded ID for cholestreol pathway
95409view11:49, 14 December 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(+)-Zaragozic acidMetaboliteCHEBI:83934 (ChEBI)
(1-Methyl-1-{[3-(3-phenoxyphenyl)propyl]carbamoyl}ethyl)phosphonateMetabolite
2-fluoromevalonate 5-diphosphateMetaboliteQ27071897 (Wikidata) Only found for Rattus norvegicus.
3-hydroxy-3-methyl-6-phosphohexanoic acidMetaboliteQ27073729 (Wikidata) Only found for Rattus norvegicus.
3-hydroxy-3-methylglutaryl-CoAMetaboliteQ27108899 (Wikidata)
6-fluoromevalonate 5-diphosphateMetaboliteQ27074009 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
BPH-608MetaboliteQ27075443 (Wikidata)
BPH-628MetaboliteQ27075447 (Wikidata)
BPH-629MetaboliteQ27075449 (Wikidata)
BPH-675MetaboliteQ27075451 (Wikidata)
BPH-676MetaboliteQ27075453 (Wikidata)
BPH-830MetaboliteQ27075459 (Wikidata)
CHEMBL1160328MetaboliteCHEMBL1160328 (ChEMBL compound)
CHEMBL1160330MetaboliteCHEMBL1160330 (ChEMBL compound)
CHEMBL1207858MetaboliteCHEMBL1207858 (ChEMBL compound)
CHEMBL1208103MetaboliteCHEMBL1208103 (ChEMBL compound)
CHEMBL24362MetaboliteCHEMBL24362 (ChEMBL compound)
CHEMBL39102MetaboliteCHEMBL39102 (ChEMBL compound)
CHEMBL39312MetaboliteCHEMBL39312 (ChEMBL compound)
Cinnamic acidMetaboliteHMDB00567 (HMDB) Only found for Rattus norvegicus.
Compound 13 MetabolitePMID: 19456099
FDFT1ProteinQ21108578 (Wikidata)
FDPSProteinQ21107439 (Wikidata)
FluvastatinMetaboliteQ417942 (Wikidata)
GGPS1ProteinQ21106540 (Wikidata)
HMGCRProteinP04035 (Uniprot-TrEMBL)
HMGCS1ProteinQ21118293 (Wikidata)
IDI1ProteinQ21151146 (Wikidata)
IDI2ProteinQ21132842 (Wikidata)
L-659699ProteinOnly found for Rattus norvegicus. L-659699 is a.k.a. (E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid
MVDProteinP53602 (Uniprot-TrEMBL)
MVKProteinQ424031 (Wikidata)
NE58018Metabolite405372 (PubChem-compound)
NE58062MetaboliteQ27087889 (Wikidata)
NE97220MetaboliteQ27087890 (Wikidata)
P'-geranyl 2-fluoromevalonate 5-diphosphateMetaboliteQ27088347 (Wikidata)
PMVKProteinQ22676988 (Wikidata)
P′-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphateMetaboliteOnly found for Rattus norvegicus.
RisedronateMetaboliteHMDB15022 (HMDB)
[1-(Hydroxycarbamoyl)-4-(3-phenoxyphenyl)butyl]phosphonateMetabolite
acetoacetyl-CoAMetaboliteQ2639429 (Wikidata)
atorvastatinMetaboliteQ668093 (Wikidata)
cerivastatinMetaboliteQ423439 (Wikidata)
cholesterol synthesisPathwayWP197 (WikiPathways)
dimethylallyl-PPMetaboliteQ417398 (Wikidata)
diphosphoglycolyl prolineMetaboliteQ27077077 (Wikidata)
famesyl-PPMetaboliteQ45416123 (Wikidata)
farnesyl thiodiphosphateMetaboliteQ27077283 (Wikidata)
geranyl-PPMetaboliteQ418125 (Wikidata)
geranylgeranyl-PPMetaboliteQ774795 (Wikidata)
isoferulic acidMetaboliteQ27096447 (Wikidata) Only found for Rattus norvegicus.
isopenthyl-PPMetaboliteQ417403 (Wikidata)
lovastatinMetaboliteQ417740 (Wikidata)
mevaldyl-CoAMetabolite
mevalonate-PPMetaboliteQ45415198 (Wikidata)
mevalonate-PMetaboliteQ45414671 (Wikidata)
mevalonateMetaboliteQ27109878 (Wikidata)
p-coumaric acidMetaboliteQ99374 (Wikidata) Only found for Rattus norvegicus.
presqualene-PPMetaboliteQ27088444 (Wikidata)
protein prenylationPathway
rosuvastatinMetaboliteQ415159 (Wikidata)
simvastatinMetaboliteQ670131 (Wikidata)
sq-109MetaboliteQ7392720 (Wikidata)
squaleneMetaboliteQ407560 (Wikidata)
zoledronic acidMetaboliteQ28852343 (Wikidata)

Annotated Interactions

No annotated interactions

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