PI3K-Akt Signaling Pathway (Homo sapiens)

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GYS2CCND2CCNE1CCNE21-19GYS1PPPPTSC2PPAntigenCytokineHypoxiaECMCytokineRChemokine SignalingPathwayPIP2VEGF SignalingPathwayNitric oxideFoxO SignalingPathwayAngiogenesisApoptosisITGA5Glycolysis and GluconeogenesisCell CycleCell proliferationInsulin SignalingPathwayJAK/STATSignaling PathwaymTOR SignalingPathwayFocal AdhesionErbB SignalingPathwayToll-like ReceptorSignaling PathwayDNA RepairB Cell Receptor Signaling PathwayPIP3AMPMAPK SignalingPathwayTSC1PPPIK3CACSF3GRB2JAK3JAK2EPOCOL4A2CHADITGB7TNRCOL4A5LAMB3IFNA1CSH1COMPCOL1A2ITGB4FN1THBS2IL3RAPIK3R1COL6A3AKT1PPPRELNPTK2LAMC3IL2RBIFNA4LAMC2IFNAR1LAMB1ITGA7ITGB6ITGA2BITGA9ITGA2PIK3R2COL4A6ITGA1OSMRDDIT4ITGA3TNCCOL6A6LAMA4ITGA8COL4A1LAMA3LAMC1LAMB2THBS4COL2A1JAK1PIK3CBTHBS3ITGA10ITGAVPRLRIL7RITGA6LAMA5IL6RITGB1IBSPCOL6A2VWFTNXBITGB5TNNSPP1PTENLAMA2CSF3RIL2RAEPORCOL6A1IL4RLAMA1SOS1ITGB3PIK3CDITGB8VTNTHBS1AKT3P20COL1A1COL4A3PIK3R3COL6A5IL2RGIFNA2IFNAR2COL4A4AKT2PPITGA4GHRITGA11PIK3R5EFNA1FGF1FGF11FGF10EFNA2EGFFGF12CSF1ANGPT4ANGPT2ANGPT1VEGFAEFNA3EFNA4EFNA5FGF14FGF5FGF19FGF17FGF18FGF2FGF3FGF4FGF6FGF7FGF8FGF9VEGFDHGFIGF1IGF2INSKITLGKik1b4FLT3LGVEGFCVEGFBPDGFBPGFPDGFANGFPDGFCFGF21FGF23FGF22PDGFDFGF20FGF13Growth FactorFGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKRTKIFNA5IFNA6IFNA7IFNA8IFNA10IFNA14IFNB1IL2OSMPRLIFNA13CHRM1LPAR1F2RCHRM2LPAR5LPAR2LPAR3LPAR6LPAR4GPCRGNB2GNB1GNB4GNGT1GNG10GNG12GNB3GByGNG2GNG3GNG4GNG5GNG7GNG8GNGT2GNG13GNG11PIK3CGNRASKRASHRASChemokines, Homones, NeurotransmittersPRKAA1PRKAA2MLST8RHEBMTORRPTORTHEM4CDC37HSP90AB1PHLPP1TCL1APDPK1PPP2CBPPP2CAPPP2R2APPP2R5DPPP2R5BPPP2R2BPPP2R1BPPP2R3BPPP2R3APPP2R5CPPP2R5EPPP2R2CPPP2R1APPP2R2DPPP2R5APPP2R3CHSP90AA1HSP90B1PHLPP2Mtcp1TCL1BRAF1MAP2K2MAP2K1MAPK1MAPK3GSK3BPFOXO3PPPPPPIKBKBPPBADPCASP9PMDM2PPPIKBKGPPCDKN1BPCDKN1APATF2CREB3CREB1PATF4CREB3L2CREB3L3ATF6BCREB3L1CREB3L4CREB5Cell SurvivalCell Cycle ProgressionProtein SynethesisMetabolism-pRPS6KB1PPPPPPPPRPS6KB2PPPEIF4EBP1PPPPEIF4BPRPS6PPEIF4EEIF4E2EIF4E1BIRS1PIK3R6CSH2GH1GH2IFNA16IFNA17IFNA21IL3IL4IL6IL7GNB5CD19PPIK3AP1BCRSYKTLR2TLR4Pathogen-associatedmolecular patterns(PAMPS)RAC1SOS2LAMB4COL9A1COL9A2COL9A3TP53CHUKNFKB1RELABCL2L1MYBFGF19NTF3NTF4BDNFTGFAFLT3NTRK1NTRK2STK11BCL2MCL1BCL2BCL2L1RBL2CDKN1BFASLGBCL2L11CDK2CDK4CDK6CCND1PCCND3PCK1PCK2G6PCG6PC2G6PC3MYCPPBRCA1PNOS3PRKCAPPPKN1PPKN2PPPPPKN3Glucose uptakeVesicle transportActin reorganizationC8orf44-SGK3SGK1PPSGK2PSGK3PSurvival signal,Growth and proliferation


Description

The PI3K-Akt signaling pathway can be activated by many types of cellular stimuli or toxic insults and regulates many fundamental cellular functions. Activated PI3K phosphorylates AKT, thereby activating it. Once active, Akt controls a number of downstream cellular processes, including apoptosis, protein synthesis, metabolism, and cell cycle, by phosphorylating a range of substrates. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

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  20. Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR; ''Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.''; Biochem J, 1998 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106781view13:26, 17 September 2019MaintBotHMDB identifier normalization
106516view21:14, 5 September 2019KhanspersModified description
105775view19:41, 15 August 2019KhanspersModified description
96453view11:31, 15 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
95701view19:55, 18 January 2018KhanspersOntology Term : 'cell cycle pathway' added !
95695view19:49, 18 January 2018KhanspersModified description
95694view19:48, 18 January 2018KhanspersModified description
95693view19:48, 18 January 2018KhanspersModified description
95684view18:19, 18 January 2018AriuttaOntology Term : 'cancer pathway' added !
95683view18:18, 18 January 2018AriuttaOntology Term : 'cancer' added !
95682view18:08, 18 January 2018AriuttaModified description
95163view00:42, 18 November 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
AKT2GeneProductENSG00000105221 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652
AKT3GeneProductENSG00000117020 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797
AMPMetaboliteCHEBI:16027 (ChEBI)
ANGPT1GeneProductENSG00000154188 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11600
ANGPT2GeneProductENSG00000091879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11601
ANGPT4GeneProductENSG00000101280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11602
ATF2GeneProductENSG00000115966 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11909
ATF4GeneProductENSG00000128272 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11911
ATF6BGeneProductENSG00000213676 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12915
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
B Cell Receptor Signaling PathwayPathwayWP23 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BCL2GeneProductENSG00000171791 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCL2L11GeneProductENSG00000153094 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCL2L1GeneProductENSG00000171552 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCRGeneProduct102723407 (Entrez Gene) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
BDNFGeneProductENSG00000176697 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
BRCA1GeneProductENSG00000012048 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
C8orf44-SGK3GeneProductENSG00000270024 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
CASP9GeneProductENSG00000132906 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371
CCND1GeneProductENSG00000110092 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCND2GeneProductENSG00000118971 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCND3GeneProductENSG00000112576 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCNE1GeneProductENSG00000105173 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCNE2GeneProductENSG00000175305 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CD19GeneProductENSG00000177455 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
CDC37GeneProductENSG00000105401 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12539
CDK2GeneProductENSG00000123374 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDK4GeneProductENSG00000135446 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDK6GeneProductENSG00000105810 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDKN1AGeneProductENSG00000124762 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575
CDKN1BGeneProductENSG00000111276 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CHADGeneProductENSG00000136457 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12643
CHRM1GeneProductENSG00000168539 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12669
CHRM2GeneProductENSG00000181072 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:243764
CHUKGeneProductENSG00000213341 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
COL1A1GeneProductENSG00000108821 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12842
COL1A2GeneProductENSG00000164692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12843
COL2A1GeneProductENSG00000139219 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12824
COL4A1GeneProductENSG00000187498 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12826
COL4A2GeneProductENSG00000134871 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12827
COL4A3GeneProductENSG00000169031 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12814
COL4A4GeneProductENSG00000081052 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12829
COL4A5GeneProductENSG00000188153 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12815
COL4A6GeneProductENSG00000197565 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94216
COL6A1GeneProductENSG00000142156 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12825
COL6A2GeneProductENSG00000142173 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12834
COL6A3GeneProductENSG00000163359 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12831
COL6A5GeneProductENSG00000172752 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL6A6GeneProductENSG00000206384 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12832
COL9A1GeneProductENSG00000112280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL9A2GeneProductENSG00000049089 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL9A3GeneProductENSG00000092758 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COMPGeneProductENSG00000105664 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12845
CREB1GeneProductENSG00000118260 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912
CREB3GeneProductENSG00000107175 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913
CREB3L1GeneProductENSG00000157613 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427
CREB3L2GeneProductENSG00000182158 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647
CREB3L3GeneProductENSG00000060566 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677
CREB3L4GeneProductENSG00000143578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284
CREB5GeneProductENSG00000146592 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991
CSF1GeneProductENSG00000184371 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12977
CSF1RGeneProductENSG00000182578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
CSF3GeneProductENSG00000108342 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12985
CSF3RGeneProductENSG00000119535 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
CSH1GeneProductENSG00000136488 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
CSH2GeneProductENSG00000213218 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
Cell CyclePathwayWP179 (WikiPathways)
Cell proliferationPathway
Chemokine Signaling PathwayPathwayWP3929 (WikiPathways)
DDIT4GeneProductENSG00000168209 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
DNA RepairPathwayWP707 (WikiPathways)
EFNA1GeneProductENSG00000169242 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13636
EFNA2GeneProductENSG00000099617 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13637
EFNA3GeneProductENSG00000143590 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13638
EFNA4GeneProductENSG00000243364 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13639
EFNA5GeneProductENSG00000184349 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
EGFGeneProductENSG00000138798 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13645
EGFRGeneProductENSG00000146648 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
EIF4BGeneProductENSG00000063046 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75705
EIF4E1BGeneProductENSG00000175766 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218268
EIF4E2GeneProductENSG00000135930 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26987
EIF4EBP1GeneProductENSG00000187840 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13685
EIF4EGeneProductENSG00000151247 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13684
EPHA2GeneProductENSG00000142627 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
EPOGeneProductENSG00000130427 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13856
EPORGeneProductENSG00000187266 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13857
ErbB Signaling PathwayPathwayWP673 (WikiPathways)
F2RGeneProductENSG00000181104 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14062
FASLGGeneProductENSG00000117560 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
FGF10GeneProductENSG00000070193 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14165
FGF11GeneProductENSG00000161958 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14166
FGF12GeneProductENSG00000114279 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14167
FGF13GeneProductENSG00000129682 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80903
FGF14GeneProductENSG00000102466 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14169
FGF17GeneProductENSG00000158815 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14171
FGF18GeneProductENSG00000156427 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF19GeneProductENSG00000162344 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF1GeneProductENSG00000113578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14164
FGF20GeneProductENSG00000078579 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80857
FGF21GeneProductENSG00000105550 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56636
FGF22GeneProductENSG00000070388 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67112
FGF23GeneProductENSG00000118972 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14173
FGF3GeneProductENSG00000186895 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14174
FGF4GeneProductENSG00000075388 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14175
FGF5GeneProductENSG00000138675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14168
FGF6GeneProductENSG00000111241 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14177
FGF7GeneProductENSG00000140285 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14178
FGF8GeneProductENSG00000107831 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14179
FGF9GeneProductENSG00000102678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14180
FGFR1GeneProductENSG00000077782 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
FGFR2GeneProductENSG00000066468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
FGFR3GeneProductENSG00000068078 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
FGFR4GeneProductENSG00000160867 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1GeneProductENSG00000102755 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT3GeneProductENSG00000122025 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FLT3LGGeneProductENSG00000090554 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FN1GeneProductENSG00000115414 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14268
FOXO3GeneProductENSG00000118689 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56484
Focal AdhesionPathwayWP306 (WikiPathways)
FoxO Signaling PathwayPathway
G6PC2GeneProductENSG00000152254 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
G6PC3GeneProductENSG00000141349 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
G6PCGeneProductENSG00000131482 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
GH1GeneProductENSG00000259384 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
GH2GeneProductENSG00000136487 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
GHRGeneProductENSG00000112964 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14600
GNB1GeneProductENSG00000078369 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14688
GNB2GeneProductENSG00000172354 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14693
GNB3GeneProductENSG00000111664 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14695
GNB4GeneProductENSG00000114450 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14696
GNB5GeneProductENSG00000069966 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702
GNG10GeneProductENSG00000242616 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14700
GNG11GeneProductENSG00000127920 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66066
GNG12GeneProductENSG00000172380 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14701
GNG13GeneProductENSG00000127588 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64337
GNG2GeneProductENSG00000186469 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702
GNG3GeneProductENSG00000162188 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14704
GNG4GeneProductENSG00000168243 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14706
GNG5GeneProductENSG00000174021 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14707
GNG7GeneProductENSG00000176533 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14708
GNG8GeneProductENSG00000167414 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14709
GNGT1GeneProductENSG00000127928 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14699
GNGT2GeneProductENSG00000167083 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14710
GRB2GeneProductENSG00000177885 (Ensembl)
  • GRB2; growth factor receptor-bound protein 2
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14784
GSK3BGeneProductENSG00000082701 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56637
GYS1GeneProductENSG00000104812 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
GYS2GeneProductENSG00000111713 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
Glycolysis and GluconeogenesisPathwayWP534 (WikiPathways)
HGFGeneProductENSG00000019991 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15234
HRASGeneProductENSG00000174775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
HSP90AA1GeneProductENSG00000080824 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15519
HSP90AB1GeneProductENSG00000096384 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15516
HSP90B1GeneProductENSG00000166598 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22027
IBSPGeneProductENSG00000029559 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15891
IFNA10GeneProductENSG00000186803 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15972
IFNA13GeneProductENSG00000233816 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:404549
IFNA14GeneProductENSG00000228083 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA16GeneProductENSG00000147885 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA17GeneProductENSG00000234829 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA1GeneProductENSG00000197919 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15962
IFNA21GeneProductENSG00000137080 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA2GeneProductENSG00000188379 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15964
IFNA4GeneProductENSG00000236637 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15965
IFNA5GeneProductENSG00000147873 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15967
IFNA6GeneProductENSG00000120235 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15968
IFNA7GeneProductENSG00000214042 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15969
IFNA8GeneProductENSG00000120242 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15970
IFNAR1GeneProductENSG00000142166 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15975
IFNAR2GeneProductENSG00000159110 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15976
IFNB1GeneProductENSG00000171855 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15977
IGF1GeneProductENSG00000017427 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16000
IGF1RGeneProductENSG00000140443 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
IGF2GeneProductENSG00000167244 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
IKBKBGeneProductENSG00000104365 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16150
IKBKGGeneProductENSG00000269335 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
IL2GeneProductENSG00000109471 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL2RAGeneProductENSG00000134460 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16184
IL2RBGeneProductENSG00000100385 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16185
IL2RGGeneProductENSG00000147168 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16186
IL3GeneProductENSG00000164399 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL3RAGeneProductENSG00000185291 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16188
IL4GeneProductENSG00000113520 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL4RGeneProductENSG00000077238 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16190
IL6GeneProductENSG00000136244 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL6RGeneProductENSG00000160712 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16194
IL7GeneProductENSG00000104432 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL7RGeneProductENSG00000168685 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16197
INSGeneProductENSG00000254647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16334
INSRGeneProductENSG00000171105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1GeneProductENSG00000169047 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
ITGA10GeneProductENSG00000143127 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000090210
ITGA11GeneProductENSG00000137809 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319480
ITGA1GeneProductENSG00000213949 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105083
ITGA2BGeneProductENSG00000005961 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16399
ITGA2GeneProductENSG00000164171 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16398
ITGA3GeneProductENSG00000005884 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16400
ITGA4GeneProductENSG00000115232 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16401
ITGA5GeneProductENSG00000161638 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16402
ITGA6GeneProductENSG00000091409 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16403
ITGA7GeneProductENSG00000135424 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16404
ITGA8GeneProductENSG00000077943 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241226
ITGA9GeneProductENSG00000144668 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104099
ITGAVGeneProductENSG00000138448 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96608
ITGB1GeneProductENSG00000150093 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16412
ITGB3GeneProductENSG00000259207 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16416
ITGB4GeneProductENSG00000132470 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192897
ITGB5GeneProductENSG00000082781 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16419
ITGB6GeneProductENSG00000115221 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16420
ITGB7GeneProductENSG00000139626 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16421
ITGB8GeneProductENSG00000105855 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320910
Insulin Signaling PathwayPathwayWP481 (WikiPathways)
JAK/STAT Signaling PathwayPathwayWP2593 (WikiPathways)
JAK1GeneProductENSG00000162434 (Ensembl)
  • CAV1; caveolin 1 caveolae protein 22kD
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16451
JAK2GeneProductENSG00000096968 (Ensembl)
  • CAV2; caveolin 2
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
JAK3GeneProductENSG00000105639 (Ensembl)
  • CAV3; caveolin 3
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16453
KDRGeneProductENSG00000128052 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
KITGeneProductENSG00000157404 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
KITLGGeneProductENSG00000049130 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17311
KRASGeneProductENSG00000133703 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
Kik1b4GeneProduct
LAMA1GeneProductENSG00000101680 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16772
LAMA2GeneProductENSG00000196569 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16773
LAMA3GeneProductENSG00000053747 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024421
LAMA4GeneProductENSG00000112769 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16775
LAMA5GeneProductENSG00000130702 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16776
LAMB1GeneProductENSG00000091136 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16777
LAMB2GeneProductENSG00000172037 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16779
LAMB3GeneProductENSG00000196878 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16780
LAMB4GeneProductENSG00000091128 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
LAMC1GeneProductENSG00000135862 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226519
LAMC2GeneProductENSG00000058085 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16782
LAMC3GeneProductENSG00000050555 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23928
LPAR1GeneProductENSG00000198121 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14745
LPAR2GeneProductENSG00000064547 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53978
LPAR3GeneProductENSG00000171517 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:65086
LPAR4GeneProductENSG00000147145 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78134
LPAR5GeneProductENSG00000184574 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:381810
LPAR6GeneProductENSG00000139679 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67168
MAP2K1GeneProductENSG00000169032 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26395
MAP2K2GeneProductENSG00000126934 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26396
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
MAPK3GeneProductENSG00000102882 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26417
MCL1GeneProductENSG00000143384 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MDM2GeneProductENSG00000135679 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
METGeneProductENSG00000105976 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
MLST8GeneProductENSG00000167965 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56716
MTORGeneProductENSG00000198793 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56717
MYBGeneProductENSG00000118513 (Ensembl)