GABA receptor signaling (Homo sapiens)

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1nerve terminalExtracellular spaceclathrin-coated vesicleGABA-A-receptorUbCytoplasmTranslocation/Transportclathrin-coated pitAP2LegendGlial cellGABRB1GABRPDNM1SLC6A11AP2A1GABRB2UBQLN1GABA-B-receptorGABRG2GABRQbenzodiazepinesK+ channelGABRG1GAD2NSFAP2S1adenylate cyclaseABATGABRB3gamma-hydroxybutyrate AP2A2AP2M1AP2B1SLC32A1succinic semialdehydecalcium influxGAD1GPHNsuccinate L-glutamateABATALDH9A1VIAATCl-GABREGADGABRDGAT1G-protein (small monomeric Small GTPase)Ca2+ channelG-protein (large Heterotrimeric)GABRG3BarbituratesALDH4BaclofenGABRA1citrate cycleGABAGABARAPsynapsePresynaptic neuronSynaptic vesicleGABAGABArelease of GABAGABAGAT3GABAALDH9A1gamma-hydroxybutyrate ABATsuccinate citrate cyclesuccinic semialdehydeALDH4ABATPostsynaptic neuronGABA-B-receptor (sub.1)GABACl-Cl-Cl-Cl-golgiGABA-B-receptor (sub.2)GABA-B-receptor (sub.1)GABA-B-receptor (sub.2)GABRA3GABRA5GABRA2GABRA4GABRA6UbGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorAP2GABARAPNSFUBQLN1GPHNGABARAP


Description

GABA is the main inhibitory neurotransmitter in the mammalian CNS. It is synthesized from glutamate by the enzyme L-glutamic acid decarboxylase. The GABA transporter GAT, located in the plasma membrane of nerve terminals and glial cells, plays an important role in the termination of synaptic transmission. GABA enters the cell via GAT and is then converted to gamma hydroxybutarate or succinate, the latter eventually entering the citrate cycle.

There are three GABA receptors: GABA(A), GABA(B) and GABA(C) receptor. GABA(A) and GABA(C) receptors belong to the family of transmitter-gated ion channels while GABA(B) receptor is a G protein coupled receptor which is activated by baclofen. GABA(A) receptors are hetero-oligomeric Cl- channels that are modulated by barbiturates and benzodiazepines. GABA(A)R-associated protein (GABARAP) is localized in the golgi and plays a role in intracellular GABA (A) receptor transport via its ability to interact with N-ethylmaleimide-sensitive factor (NSF) and gephyrin (GPHN). Surface receptor number is important since it is a determinant of inhibitory synapse strength. It is controlled by removal of receptors from the membrane by interaction with the clathrin adaptor AP2 followed by recruitment into clathrin-coated pits. GABA(A) receptors can then be targeted for proteasomal degradation.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. ''''; https://targetexplorer.ingenuity.com/pathway/ING/ING:cih#!/api/rest/v1/client/searchPathwayNodes?pathwayId=ING:cih&rows=0&facetLimit=5000&responseType=default,

History

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CompareRevisionActionTimeUserComment
119288view11:01, 23 June 2021Finterlymoved url info to Source for PublicationXref
117730view12:37, 22 May 2021EweitzModified title
107556view23:56, 19 October 2019AlexanderPicoremoved incomplete and duplicate description
106425view23:19, 28 August 2019KhanspersModified description
105601view04:50, 10 August 2019KhanspersModified description
97503view13:28, 24 May 2018IreneHemelAddition of two GAD isoforms
94955view12:23, 19 October 2017DeSlOntology Term : 'synaptic vesicle exocytosis - neurotransmitter release pathway' added !
94954view12:22, 19 October 2017DeSlOntology Term : 'neurotransmitter metabolic pathway' added !
94953view12:21, 19 October 2017DeSlOntology Term : 'calcium channel blocker drug pathway' added !
94952view12:18, 19 October 2017DeSladded missing IDs for nodes, changed datasource annotation to wikidata where needed.
94951view12:08, 19 October 2017DeSladded all nodes from ref.
94950view10:05, 19 October 2017DeSlAdded part of PW in postsynaptic neuron.
94931view14:00, 13 October 2017DeSlOntology Term : 'gamma-aminobutyric acid signaling pathway' added !
94930view13:58, 13 October 2017DeSlOntology Term : 'benzodiazepine pharmacodynamics pathway' added !
94929view13:57, 13 October 2017DeSlOntology Term : 'GABAergic neuron' added !
94928view13:56, 13 October 2017DeSlOntology Term : 'signaling pathway' added !
94927view13:54, 13 October 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABATGeneProductQ18300885 (Wikidata)
ALDH4ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
ALDH9A1GeneProductENSG00000143149 (Ensembl)
AP2A1GeneProductENSG00000196961 (Ensembl)
AP2A2GeneProduct161 (Entrez Gene)
AP2B1GeneProductENSG00000006125 (Ensembl)
AP2M1GeneProductENSG00000161203 (Ensembl)
AP2S1GeneProductENSG00000042753 (Ensembl)
BaclofenMetaboliteQ413717 (Wikidata)
BarbituratesMetaboliteQ206348 (Wikidata)
Ca2+ channelQ246819 (Wikidata)
Cl-MetaboliteQ108200 (Wikidata)
DNM1GeneProductQ1181014 (Wikidata)
G-protein (large Heterotrimeric)Protein3.6.5.1 (Enzyme Nomenclature) guanine nucleotide-binding proteins
G-protein (small monomeric Small GTPase)Protein3.6.5.2 (Enzyme Nomenclature) guanine nucleotide-binding proteins
GABA-B-receptor (sub.1)ProteinQ9UBS5 (Uniprot-TrEMBL)
GABA-B-receptor (sub.2)ProteinO75899 (Uniprot-TrEMBL)
GABA-B-receptorProteinQ9UBS5 (Uniprot-TrEMBL)
GABAMetaboliteQ210021 (Wikidata)
GABARAPGeneProductQ18036482 (Wikidata)
GABRA1ProteinENSG00000022355 (Ensembl)
GABRA2ProteinENSG00000151834 (Ensembl)
GABRA3ProteinENSG00000011677 (Ensembl)
GABRA4ProteinENSG00000109158 (Ensembl)
GABRA5ProteinENSG00000186297 (Ensembl)
GABRA6ProteinQ16445 (Uniprot-TrEMBL)
GABRB1ProteinENSG00000163288 (Ensembl)
GABRB2ProteinENSG00000145864 (Ensembl)
GABRB3ProteinENSG00000166206 (Ensembl)
GABRDProteinENSG00000187730 (Ensembl)
GABREProteinENSG00000102287 (Ensembl)
GABRG1ProteinENSG00000163285 (Ensembl)
GABRG2ProteinENSG00000113327 (Ensembl)
GABRG3ProteinENSG00000182256 (Ensembl)
GABRPProteinENSG00000094755 (Ensembl)
GABRQProteinENSG00000268089 (Ensembl)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GADProtein4.1.1.15 (Enzyme Nomenclature) glutamic acid decarboxylase
GAT1GeneProductP30531 (Uniprot-TrEMBL)
GAT3ProteinP48066 (Uniprot-TrEMBL)
GPHNGeneProductENSG00000171723 (Ensembl)
K+ channelQ42262185 (Wikidata)
L-glutamateMetaboliteQ41875350 (Wikidata)
NSFGeneProductQ6951477 (Wikidata)
SLC32A1GeneProductENSG00000101438 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
UBQLN1GeneProductQ18039745 (Wikidata)
VIAATProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
adenylate cyclaseProteinQ356257 (Wikidata)
benzodiazepinesMetaboliteQ83871 (Wikidata)
calcium influxMetaboliteQ23905776 (Wikidata)
citrate cyclePathwayWP78 (WikiPathways)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
release of GABAMetaboliteQ210021 (Wikidata)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteQ4602542 (Wikidata)

Annotated Interactions

No annotated interactions

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