Macrophage markers (Homo sapiens)

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Immune cell specific expression(based on GeneAtlas)CD14CD831, 5CD68F33CD16326-8CD86CD74Cd52RAC2LYZ4Macrophage markers


Description

Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes.

Based on this list and tissue-specific gene expression from GeneAtlas.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP2271 (rev 69962) with a 90.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Brettschneider J, Ecker D, Bitsch A, Bahner D, Bogumil T, Dressel A, Elitok E, Kitze B, Poser S, Weber F, Tumani H; ''The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b.''; J Neuroimmunol, 2002 PubMed Europe PMC Scholia
  2. Töröcsik D, Bárdos H, Nagy L, Adány R; ''Identification of factor XIII-A as a marker of alternative macrophage activation.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
  3. Kunz-Schughart LA, Weber A, Rehli M, Gottfried E, Brockhoff G, Krause SW, Andreesen R, Kreutz M; ''[The "classical" macrophage marker CD68 is strongly expressed in primary human fibroblasts].''; Verh Dtsch Ges Pathol, 2003 PubMed Europe PMC Scholia
  4. Aperlo C, Sevilla L, Guerin S, Pognonec P, Boulukos KE; ''Synergistic effects of colony-stimulating factor 1 and leukemia inhibitory factor in inducing early myeloid cell differentiation.''; Cell Growth Differ, 1998 PubMed Europe PMC Scholia
  5. Mahnke K, Becher E, Ricciardi-Castagnoli P, Luger TA, Schwarz T, Grabbe S; ''CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide.''; Adv Exp Med Biol, 1997 PubMed Europe PMC Scholia
  6. Lau SK, Chu PG, Weiss LM; ''CD163: a specific marker of macrophages in paraffin-embedded tissue samples.''; Am J Clin Pathol, 2004 PubMed Europe PMC Scholia
  7. Hiraoka A, Horiike N, Akbar SM, Michitaka K, Matsuyama T, Onji M; ''Expression of CD163 in the liver of patients with viral hepatitis.''; Pathol Res Pract, 2005 PubMed Europe PMC Scholia
  8. Fonseca JE, Edwards JC, Blades S, Goulding NJ; ''Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments.''; Arthritis Rheum, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
107552view23:36, 19 October 2019AlexanderPicoModified description
106639view21:02, 12 September 2019KhanspersModified description
105642view05:08, 10 August 2019KhanspersModified description
94392view12:26, 6 September 2017MkutmonOntology Term : 'macrophage' added !
94391view12:25, 6 September 2017MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CD14GeneProductENSG00000170458 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12475
CD163GeneProductENSG00000177575 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93671
CD68GeneProductENSG00000129226 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12514
CD74GeneProductENSG00000019582 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16149
CD83GeneProductENSG00000112149 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12522
CD86GeneProductENSG00000114013 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12524
Cd52GeneProductNo homologues found for original id L:23833
F3GeneProductENSG00000117525 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14066
LYZGeneProductENSG00000090382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17105
RAC2GeneProductENSG00000128340 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19354

Annotated Interactions

No annotated interactions
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