Metabolism of Spingolipids in ER and Golgi apparatus (Homo sapiens)

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SPHK2SPHK11Endoplasmic ReticulumTranslocation from ER to Golgi apparatusGalactosyltransferase (GalT1)sphingosine kinaseGalNacTneutral GSLsSATIGT3GA2GD3GM3B3GALNT1ethanolamine phosphateDihydroceramideSphinganine3-ketosphinganineCeramidehexadecanalSphinganine 1-phosphateSphingosineSphingosine-1-phosphateSPL1SPHK2SPHK1sphingosine kinaseSPGG1SPGG2SPGG1SPGG2SPTLC1P1SPTLC1P2SPTLC1P3SPTLC1P4SPTLC1P5KDSRCERS3Golgi apparatusgalactosyl-ceramideceramide-1-phosphateGalCer synthaseCERKSphingomyelinglucosylceramideSulfatidegalactosylceramideSGMS2GlcCer synthaselactosylceramideB3GALT1B4GALNT1B4GALT1GALNTL1GALNT1serinePalmitoyl CoACeramidegalactosyl-ceramideDEGS2DEGS1Dihydroceramide desaturaseSPL1GM2GM1aGD1aGD2GD1bGT1bGT2GT1cGQ1cGA1GM1bSATIVGalNacTGalNacTGalNacTSATIVSATIVSATIVSATIISATIIIB3GALT2B4GALT2B3GALT2B4GALT2B3GALT2B4GALT2B3GALT2B4GALT2SGMS1


Description

The metabolism of SphingoLipids (SLs) in the ER and Golgi apparatus. Sphingolipids, or glycosyl-ceramides, are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. These compounds play important roles in signal transmission and cell recognition.

Quality Tags

Ontology Terms

 

Bibliography

  1. Lahiri, S., A. H. Futerman; ''The metabolism and function of sphingolipids and glycosphingolipids''; Cellular and Molecular Life Sciences, 2007

History

View all...
CompareRevisionActionTimeUserComment
97513view13:43, 24 May 2018Youssefwalid
97509view13:38, 24 May 2018YoussefwalidChanged mapping of SATIII to UniprotSwiss
96377view06:42, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95051view14:18, 10 November 2017DeSlChanged metabolite nodes to protein nodes.
95050view13:55, 10 November 2017DeSlChanged metabolite nodes to enzyme nodes where appropriate.
94435view11:02, 8 September 2017DeSlConnected last line, changed name of wrong metabolite (one of the sphingosine nodes is actually sphingosine-1-phosphate).
94432view09:37, 8 September 2017DeSlAdded enzyme node (SGMS1) and identifier
94288view12:53, 31 August 2017DeSlChanged title
94287view12:19, 31 August 2017DeSlAdded everything after lactosylceramide.
94285view20:34, 30 August 2017DeSlOntology Term : 'lacto-series glycosphingolipid metabolic pathway' added !
94284view20:34, 30 August 2017DeSlOntology Term : 'glycosphingolipid metabolic pathway' added !
94283view20:27, 30 August 2017DeSlChanged appearance of PW.
94275view14:44, 30 August 2017DeSlOntology Term : 'sphingolipid metabolic pathway' added !
94274view14:44, 30 August 2017DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
94273view14:43, 30 August 2017DeSlModified description
94272view14:28, 30 August 2017DeSlMade 2 seperate nodes from palmitoyl CoA and Serine, drew lines for translocation.
94271view14:04, 30 August 2017DeSlAdded literature reference
94270view14:01, 30 August 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-ketosphinganineMetaboliteQ27073739 (Wikidata)
B3GALNT1ProteinENSG00000169255 (Ensembl)
B3GALT1ProteinENSG00000172318 (Ensembl)
B3GALT2ProteinQ18033232 (Wikidata) GalTII = galactosyltransferase
B4GALNT1ProteinENSG00000135454 (Ensembl)
B4GALT1ProteinENSG00000086062 (Ensembl)
B4GALT2ProteinQ18033229 (Wikidata) GalTII = galactosyltransferase
CERKProteinQ5063674 (Wikidata) Ceramide Kinase
CERS3ProteinQ17113326 (Wikidata) dihydroceramide synthase
CeramideMetaboliteCHEBI:17761 (ChEBI)
DEGS1MetaboliteQ21105760 (Wikidata)
DEGS2MetaboliteQ21115762 (Wikidata)
Dihydroceramide desaturaseMetaboliteQ17117943 (Wikidata)
DihydroceramideMetaboliteHMDB06752 (HMDB)
GA1MetaboliteCHEBI:27938 (ChEBI) ganglioside GA1
GA2MetaboliteCHEBI:27731 (ChEBI) ganglioside GA2
GALNT1ProteinENSG00000141429 (Ensembl)
GALNTL1ProteinQ8N428 (Uniprot-TrEMBL) GALNT16 Synonyms:GALNTL1 (uniprot)
GD1aMetaboliteCHEBI:18163 (ChEBI) ganglioside GD1a
GD1bMetaboliteCHEBI:28175 (ChEBI) ganglioside GD1b
GD2MetaboliteCHEBI:28648 (ChEBI) ganglioside GD2
GD3MetaboliteCHEBI:89636 (ChEBI) Ganglioside GD3
GM1aMetaboliteCHEBI:18216 (ChEBI) ganglioside GM1a
GM1bMetaboliteCHEBI:62370 (ChEBI) ganglioside GM1b
GM2MetaboliteCHEBI:51013 (ChEBI) ganglioside GM2
GM3MetaboliteCHEBI:15681 (ChEBI) ganglioside GM3
GQ1cMetaboliteCHEBI:87994 (ChEBI) ganglioside GQ1c
GT1bMetaboliteCHEBI:28058 (ChEBI) ganglioside GT1b
GT1cMetaboliteCHEBI:87992 (ChEBI) ganglioside GT1c
GT2MetaboliteCHEBI:61732 (ChEBI) ganglioside GT2
GT3MetaboliteCHEBI:28541 (ChEBI) ganglioside GT3
GalCer synthaseProteinQ18032287 (Wikidata) UGT8 / CGT
GalNacTProteinEC 2.4.1.41 (Enzyme Nomenclature) N-acetylgalactosaminetransferase
GlcCer synthaseProteinQ22678664 (Wikidata) glucosylceramide synthase (GCS)
KDSRProteinQ1143172 (Wikidata) 3-ketodihydrosphingosine reductase
Palmitoyl CoAMetaboliteQ3361645 (Wikidata)
SATIProteinEC 2.4.99.9 (Enzyme Nomenclature) sialyltransferase SAT1
SATIIProtein2.4.99.8 (Enzyme Nomenclature) sialyltransferase SAT2
SATIIIProteinQ8NDV1 (Uniprot-TrEMBL) sialyltransferase SAT3
SATIVProtein2.4.99.10 (Enzyme Nomenclature) sialyltransferase SAT4
SGMS1ProteinQ18053901 (Wikidata) Sphingomyelin synthase 1
SGMS2ProteinQ21123432 (Wikidata) Sphingomyelin synthase 2
SPGG1ProteinQ18047015 (Wikidata) sphingosine-1-phosphate phosphatase
SPGG2ProteinQ18049980 (Wikidata) sphingosine-1-phosphate phosphatase
SPHK1ProteinENSG00000176170 (Ensembl)
SPHK2ProteinENSG00000063176 (Ensembl)
SPL1ProteinQ21144795 (Wikidata) Sphingosine-1-phosphate lyase 1
SPTLC1P1ProteinQ18073548 (Wikidata) serine palmitoyltransferase
SPTLC1P2ProteinQ18073516 (Wikidata) serine palmitoyltransferase
SPTLC1P3ProteinQ18073519 (Wikidata) serine palmitoyltransferase
SPTLC1P4ProteinQ18073521 (Wikidata) serine palmitoyltransferase
SPTLC1P5ProteinQ18073551 (Wikidata) serine palmitoyltransferase
Sphinganine 1-phosphateMetaboliteQ27077062 (Wikidata)
SphinganineMetaboliteHMDB00269 (HMDB)
SphingomyelinMetaboliteQ423143 (Wikidata)
Sphingosine-1-phosphateMetaboliteQ418267 (Wikidata)
SphingosineMetaboliteQ46298 (Wikidata)
SulfatideMetaboliteQ408584 (Wikidata)
ceramide-1-phosphateMetaboliteQ35664620 (Wikidata) Cer-1-P
ethanolamine phosphateMetaboliteQ418826 (Wikidata)
galactosyl-ceramideMetaboliteQ2756638 (Wikidata) Galactocerebroside
galactosylceramideMetaboliteCHEBI:36498 (ChEBI) Gala-serie (=GalCer) GSLs (glycosphingolipids)
glucosylceramideMetaboliteQ35662896 (Wikidata)
hexadecanalMetaboliteQ27077978 (Wikidata)
lactosylceramideMetaboliteQ3215908 (Wikidata)
neutral GSLsMetaboliteCHEBI:25513 (ChEBI) neutral glycosphingolip = Any glycosphingolipid containing unsubstituted glycosyl moieties.
serineMetaboliteCHEBI:17822 (ChEBI)
sphingosine kinaseProteinQ7576797 (Wikidata)

Annotated Interactions

No annotated interactions

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