G1 to S cell cycle control (Mus musculus)

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1TTTCC/GCGCCheckpointbDegradationcakdp1RbDependent Kinasesorigen recognitionG1/S Cell CycleeinactiveeG1 PhaseDNA replicationCyclin EsCyclin DsE2fG1 CyclinG1/S transition PhasecomplexG1/S transition CyclinDependent KInasesG2 Phase-M phaseDNA polymerasesphosphorylation of proteinsinvolved in G1/S transitionCell cycle DNA replication genesbCdkOrc2lE2fPkmyt1CdkE2f6Mcm6Cdkn2dRpa1Cdkn2bMnat1Orc1lCdc2adp1Gadd45aCyclinDCdk4Tfdp1Prim1Orc6lE2fCcnb1-rs1Ccnd1Ccne1E2f2Rbl1Cdk6Mdm2PoleCdkCdk7Cdc45lCyclinEE2f1Ccng2CyclinDCdc2aCdc25aCdk7Pola2Ccnd2Cdkn2aE2f5MycRpa3Trp53Mcm3PcnaCdk4Cdkn2cRbRb1Ccna1Tfdp2Cdk6p53RbMcm5Ccne2Ccnd3Wee1CdkPrim2Orc5lOrc3lCdk2Mcm4Mcm2Cdkn1bPole2Orc4lE2f3Mcm7Rpa2Cdkn1aAtmE2f4CyclinECcnhCdkn1cPPPUPPPPP


In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&


GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.

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  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia


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84705view22:06, 15 March 2016Khanspersremoved problematic shapes, added states
78432view10:26, 7 January 2015MaintBotadded missing graphIds
72012view12:23, 24 October 2013Mkutmonfixed unconnected lines
71720view20:16, 17 October 2013MaintBotAutomated update of data sources
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69081view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
67268view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
41269view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35821view21:54, 17 February 2010KhanspersAdded lit ref
35820view21:53, 17 February 2010KhanspersModified description
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21552view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:WP413]]: Moved to stable identifier
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External references


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NameTypeDatabase referenceComment
AtmGeneProduct11920 (Entrez Gene)
Ccna1GeneProduct12427 (Entrez Gene)
Ccnb1-rs1GeneProduct12429 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Ccne2GeneProduct12448 (Entrez Gene)
Ccng2GeneProduct12452 (Entrez Gene)
CcnhGeneProduct66671 (Entrez Gene)
Cdc25aGeneProduct12530 (Entrez Gene)
Cdc2aGeneProduct12534 (Entrez Gene)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdk4GeneProduct12567 (Entrez Gene)
Cdk6GeneProduct12571 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Cdkn2aGeneProduct12578 (Entrez Gene)
Cdkn2bGeneProduct12579 (Entrez Gene)
Cdkn2cGeneProduct12580 (Entrez Gene)
Cdkn2dGeneProduct12581 (Entrez Gene)
E2f1GeneProduct13555 (Entrez Gene)
E2f2GeneProduct242705 (Entrez Gene)
E2f3GeneProduct13557 (Entrez Gene)
E2f4GeneProduct104394 (Entrez Gene)
E2f5GeneProduct13559 (Entrez Gene)
E2f6GeneProduct50496 (Entrez Gene)
Gadd45aGeneProduct13197 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
Mnat1GeneProduct17420 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pkmyt1GeneProduct268930 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
Rb1GeneProduct19645 (Entrez Gene)
Rbl1GeneProduct19650 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
Tfdp1GeneProduct21781 (Entrez Gene)
Tfdp2GeneProduct211586 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wee1GeneProduct22390 (Entrez Gene)

Annotated Interactions

No annotated interactions
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