Post-translational protein phosphorylation (Homo sapiens)

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12endoplasmic reticulum lumencytosolMXRA8 MSLN CYR61 FAM20C:FAM20Csubstratesp-LGALS1 p-ITIH2 SDC2 IGFBP4 GPC3 p-APOL1 IGFBP3 p-AHSG ADPPRKCSH p-IL6 p-SERPINC1 CHGB FGF23 STC2 BPIFB2 FSTL1 p-Factor V precursor p-KNG1 IL6 p-ENAM p-HRC TNC p-APOA1 LTBP1 SERPIND1 p-MGAT4A p-AMELX p-BPIFB2 KNG1 FAM20C p-AMTN p-P4HB p-BMP4 p-SPP2 p-LAMB2 LAMB1 PDIA6 NOTUM p-PENK FN1 p-GOLM1 p-IGFBP1 p-MXRA8 FAM20A p-APOB(28-4563) ATPAPOA2 p-VGF p-APOE ADAM10 p-PRKCSH p-LAMC1 SERPINC1 MGAT4A p-IGFBP4 PENK p-SERPINA10 p-CST3 SERPINA1 p-PCSK9 p-TMEM132A p-FGG IGFBP7 BMP4 p-MSLN p-SPARCL1 LGALS1 APP ITIH2 p-CYR61 FGG p-IGFBP3 p-FN1 p-CKAP4 p-APOA5 p-C4A p-APLP2 p-SERPIND1 SPP1 p-LTBP1 TMEM132A CHRDL1 p-TIMP1 C4A p-FSTL3 AHSG DNAJC3 p-CDH2 p-SERPINA1 MEPE AFP VCAN TGOLN2 p-MEPE p-GAS6 p-TNC p-TF SCG2 FSTL3 p-ADAM10 CALU RCN1 p-BMP15 MFGE8 p-STC2 p-C3 p-HSP90B1 p-ALB p-MIA3 NUCB1 p-SHISA5 MELTF FAM20C:Phosphorylated FAM20C substratesFAM20C p-AMBN PNPLA2 p-NOTUM WFS1 p-FUCA2 p-MFGE8 APLP2 p-CHRDL1 VWA1 p-EVA1A SPP2 p-CHGB p-DMP1 HRC p-FGF23 APOE p-IGFBP5 p-TGOLN2 p-IGFBP7 p-KTN1 ANO8 p-LAMB1 p-MELTF p-FBN1 APOA5 p-QSOX1 AMBN AMELX p-WFS1 p-CALU p-MBTPS1 HSP90B1 p-PNPLA2 p-AFP p-SCG3 ALB CSF1 p-MEN1 IGFBP1 CDH2 LAMB2 MBTPS1 VGF p-VCAN PRSS23 KTN1 CST3 PROC p-CSF1 FBN1 SCG3 APOA1 p-NUCB1 AMTN p-PROC EVA1A CKAP4 p-SPP1 TF p-FSTL1 p-CP p-PDIA6 MEN1 P4HB DMP1 LAMC1 p-SDC2 CP MATN3 GAS6 BMP15 p-VWA1 p-GPC3 C3 FUCA2 SPARCL1 Factor V precursor p-APP FGA p-PRSS23 p-ANO8 p-FGA SERPINA10 MIA3 APOB(28-4563) FAM20C p-SCG2 p-APOA2 SHISA5 p-DNAJC3 GOLM1 p-RCN1 ENAM PCSK9 QSOX1 IGFBP5 TIMP1 FAM20C:FAM20AAPOL1 p-MATN3


Description

Secretory pathway kinases phosphorylate a diverse array of substrates involved in many physiological processes. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 8957275
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Jupe, Steve

Quality Tags

Ontology Terms

 

Bibliography

  1. Sreelatha A, Kinch LN, Tagliabracci VS.; ''The secretory pathway kinases.''; PubMed Europe PMC
  2. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE.; ''A Single Kinase Generates the Majority of the Secreted Phosphoproteome.''; PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
101293view11:18, 1 November 2018ReactomeTeamreactome version 66
100830view20:48, 31 October 2018ReactomeTeamreactome version 65
100371view19:23, 31 October 2018ReactomeTeamreactome version 64
99918view16:07, 31 October 2018ReactomeTeamreactome version 63
99473view14:39, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99127view12:40, 31 October 2018ReactomeTeamreactome version 62
93585view11:28, 9 August 2017ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10 ProteinO14672 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AFP ProteinP02771 (Uniprot-TrEMBL)
AHSG ProteinP02765 (Uniprot-TrEMBL)
ALB ProteinP02768 (Uniprot-TrEMBL)
AMBN ProteinQ9NP70 (Uniprot-TrEMBL)
AMELX ProteinQ99217 (Uniprot-TrEMBL)
AMTN ProteinQ6UX39 (Uniprot-TrEMBL)
ANO8 ProteinQ9HCE9 (Uniprot-TrEMBL)
APLP2 ProteinQ06481 (Uniprot-TrEMBL)
APOA1 ProteinP02647 (Uniprot-TrEMBL)
APOA2 ProteinP02652 (Uniprot-TrEMBL)
APOA5 ProteinQ6Q788 (Uniprot-TrEMBL)
APOB(28-4563) ProteinP04114 (Uniprot-TrEMBL)
APOE ProteinP02649 (Uniprot-TrEMBL)
APOL1 ProteinO14791 (Uniprot-TrEMBL)
APP ProteinP05067 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
BMP15 ProteinO95972 (Uniprot-TrEMBL)
BMP4 ProteinP12644 (Uniprot-TrEMBL)
BPIFB2 ProteinQ8N4F0 (Uniprot-TrEMBL)
C3 ProteinP01024 (Uniprot-TrEMBL)
C4A ProteinP0C0L4 (Uniprot-TrEMBL)
CALU ProteinO43852 (Uniprot-TrEMBL)
CDH2 ProteinP19022 (Uniprot-TrEMBL)
CHGB ProteinP05060 (Uniprot-TrEMBL)
CHRDL1 ProteinQ9BU40 (Uniprot-TrEMBL)
CKAP4 ProteinQ07065 (Uniprot-TrEMBL)
CP ProteinP00450 (Uniprot-TrEMBL)
CSF1 ProteinP09603 (Uniprot-TrEMBL)
CST3 ProteinP01034 (Uniprot-TrEMBL)
CYR61 ProteinO00622 (Uniprot-TrEMBL)
DMP1 ProteinQ13316 (Uniprot-TrEMBL)
DNAJC3 ProteinQ13217 (Uniprot-TrEMBL)
ENAM ProteinQ9NRM1 (Uniprot-TrEMBL)
EVA1A ProteinQ9H8M9 (Uniprot-TrEMBL)
FAM20A ProteinQ96MK3 (Uniprot-TrEMBL)
FAM20C ProteinQ8IXL6 (Uniprot-TrEMBL)
FAM20C:FAM20AComplexR-HSA-8957338 (Reactome)
FAM20C:FAM20C substratesComplexR-HSA-8952321 (Reactome)
FAM20C:Phosphorylated FAM20C substratesComplexR-HSA-8952335 (Reactome)
FBN1 ProteinP35555 (Uniprot-TrEMBL)
FGA ProteinP02671 (Uniprot-TrEMBL)
FGF23 ProteinQ9GZV9 (Uniprot-TrEMBL)
FGG ProteinP02679 (Uniprot-TrEMBL)
FN1 ProteinP02751 (Uniprot-TrEMBL)
FSTL1 ProteinQ12841 (Uniprot-TrEMBL)
FSTL3 ProteinO95633 (Uniprot-TrEMBL)
FUCA2 ProteinQ9BTY2 (Uniprot-TrEMBL)
Factor V precursor ProteinP12259 (Uniprot-TrEMBL)
GAS6 ProteinQ14393 (Uniprot-TrEMBL)
GOLM1 ProteinQ8NBJ4 (Uniprot-TrEMBL)
GPC3 ProteinP51654 (Uniprot-TrEMBL)
HRC ProteinP23327 (Uniprot-TrEMBL)
HSP90B1 ProteinP14625 (Uniprot-TrEMBL)
IGFBP1 ProteinP08833 (Uniprot-TrEMBL)
IGFBP3 ProteinP17936 (Uniprot-TrEMBL)
IGFBP4 ProteinP22692 (Uniprot-TrEMBL)
IGFBP5 ProteinP24593 (Uniprot-TrEMBL)
IGFBP7 ProteinQ16270 (Uniprot-TrEMBL)
IL6 ProteinP05231 (Uniprot-TrEMBL)
ITIH2 ProteinP19823 (Uniprot-TrEMBL)
KNG1 ProteinP01042 (Uniprot-TrEMBL)
KTN1 ProteinQ86UP2 (Uniprot-TrEMBL)
LAMB1 ProteinP07942 (Uniprot-TrEMBL)
LAMB2 ProteinP55268 (Uniprot-TrEMBL)
LAMC1 ProteinP11047 (Uniprot-TrEMBL)
LGALS1 ProteinP09382 (Uniprot-TrEMBL)
LTBP1 ProteinQ14766 (Uniprot-TrEMBL)
MATN3 ProteinO15232 (Uniprot-TrEMBL)
MBTPS1 ProteinQ14703 (Uniprot-TrEMBL)
MELTF ProteinP08582 (Uniprot-TrEMBL)
MEN1 ProteinO00255 (Uniprot-TrEMBL)
MEPE ProteinQ9NQ76 (Uniprot-TrEMBL)
MFGE8 ProteinQ08431 (Uniprot-TrEMBL)
MGAT4A ProteinQ9UM21 (Uniprot-TrEMBL)
MIA3 ProteinQ5JRA6 (Uniprot-TrEMBL)
MSLN ProteinQ13421 (Uniprot-TrEMBL)
MXRA8 ProteinQ9BRK3 (Uniprot-TrEMBL)
NOTUM ProteinQ6P988 (Uniprot-TrEMBL)
NUCB1 ProteinQ02818 (Uniprot-TrEMBL)
P4HB ProteinP07237 (Uniprot-TrEMBL)
PCSK9 ProteinQ8NBP7 (Uniprot-TrEMBL)
PDIA6 ProteinQ15084 (Uniprot-TrEMBL)
PENK ProteinP01210 (Uniprot-TrEMBL)
PNPLA2 ProteinQ96AD5 (Uniprot-TrEMBL)
PRKCSH ProteinP14314 (Uniprot-TrEMBL)
PROC ProteinP04070 (Uniprot-TrEMBL)
PRSS23 ProteinO95084 (Uniprot-TrEMBL)
QSOX1 ProteinO00391 (Uniprot-TrEMBL)
RCN1 ProteinQ15293 (Uniprot-TrEMBL)
SCG2 ProteinP13521 (Uniprot-TrEMBL)
SCG3 ProteinQ8WXD2 (Uniprot-TrEMBL)
SDC2 ProteinP34741 (Uniprot-TrEMBL)
SERPINA1 ProteinP01009 (Uniprot-TrEMBL)
SERPINA10 ProteinQ9UK55 (Uniprot-TrEMBL)
SERPINC1 ProteinP01008 (Uniprot-TrEMBL)
SERPIND1 ProteinP05546 (Uniprot-TrEMBL)
SHISA5 ProteinQ8N114 (Uniprot-TrEMBL)
SPARCL1 ProteinQ14515 (Uniprot-TrEMBL)
SPP1 ProteinP10451 (Uniprot-TrEMBL)
SPP2 ProteinQ13103 (Uniprot-TrEMBL)
STC2 ProteinO76061 (Uniprot-TrEMBL)
TF ProteinP02787 (Uniprot-TrEMBL)
TGOLN2 ProteinO43493 (Uniprot-TrEMBL)
TIMP1 ProteinP01033 (Uniprot-TrEMBL)
TMEM132A ProteinQ24JP5 (Uniprot-TrEMBL)
TNC ProteinP24821 (Uniprot-TrEMBL)
VCAN ProteinP13611 (Uniprot-TrEMBL)
VGF ProteinO15240 (Uniprot-TrEMBL)
VWA1 ProteinQ6PCB0 (Uniprot-TrEMBL)
WFS1 ProteinO76024 (Uniprot-TrEMBL)
p-ADAM10 ProteinO14672 (Uniprot-TrEMBL)
p-AFP ProteinP02771 (Uniprot-TrEMBL)
p-AHSG ProteinP02765 (Uniprot-TrEMBL)
p-ALB ProteinP02768 (Uniprot-TrEMBL)
p-AMBN ProteinQ9NP70 (Uniprot-TrEMBL)
p-AMELX ProteinQ99217 (Uniprot-TrEMBL)
p-AMTN ProteinQ6UX39 (Uniprot-TrEMBL)
p-ANO8 ProteinQ9HCE9 (Uniprot-TrEMBL)
p-APLP2 ProteinQ06481 (Uniprot-TrEMBL)
p-APOA1 ProteinP02647 (Uniprot-TrEMBL)
p-APOA2 ProteinP02652 (Uniprot-TrEMBL)
p-APOA5 ProteinQ6Q788 (Uniprot-TrEMBL)
p-APOB(28-4563) ProteinP04114 (Uniprot-TrEMBL)
p-APOE ProteinP02649 (Uniprot-TrEMBL)
p-APOL1 ProteinO14791 (Uniprot-TrEMBL)
p-APP ProteinP05067 (Uniprot-TrEMBL)
p-BMP15 ProteinO95972 (Uniprot-TrEMBL)
p-BMP4 ProteinP12644 (Uniprot-TrEMBL)
p-BPIFB2 ProteinQ8N4F0 (Uniprot-TrEMBL)
p-C3 ProteinP01024 (Uniprot-TrEMBL)
p-C4A ProteinP0C0L4 (Uniprot-TrEMBL)
p-CALU ProteinO43852 (Uniprot-TrEMBL)
p-CDH2 ProteinP19022 (Uniprot-TrEMBL)
p-CHGB ProteinP05060 (Uniprot-TrEMBL)
p-CHRDL1 ProteinQ9BU40 (Uniprot-TrEMBL)
p-CKAP4 ProteinQ07065 (Uniprot-TrEMBL)
p-CP ProteinP00450 (Uniprot-TrEMBL)
p-CSF1 ProteinP09603 (Uniprot-TrEMBL)
p-CST3 ProteinP01034 (Uniprot-TrEMBL)
p-CYR61 ProteinO00622 (Uniprot-TrEMBL)
p-DMP1 ProteinQ13316 (Uniprot-TrEMBL)
p-DNAJC3 ProteinQ13217 (Uniprot-TrEMBL)
p-ENAM ProteinQ9NRM1 (Uniprot-TrEMBL)
p-EVA1A ProteinQ9H8M9 (Uniprot-TrEMBL)
p-FBN1 ProteinP35555 (Uniprot-TrEMBL)
p-FGA ProteinP02671 (Uniprot-TrEMBL)
p-FGF23 ProteinQ9GZV9 (Uniprot-TrEMBL)
p-FGG ProteinP02679 (Uniprot-TrEMBL)
p-FN1 ProteinP02751 (Uniprot-TrEMBL)
p-FSTL1 ProteinQ12841 (Uniprot-TrEMBL)
p-FSTL3 ProteinO95633 (Uniprot-TrEMBL)
p-FUCA2 ProteinQ9BTY2 (Uniprot-TrEMBL)
p-Factor V precursor ProteinP12259 (Uniprot-TrEMBL)
p-GAS6 ProteinQ14393 (Uniprot-TrEMBL)
p-GOLM1 ProteinQ8NBJ4 (Uniprot-TrEMBL)
p-GPC3 ProteinP51654 (Uniprot-TrEMBL)
p-HRC ProteinP23327 (Uniprot-TrEMBL)
p-HSP90B1 ProteinP14625 (Uniprot-TrEMBL)
p-IGFBP1 ProteinP08833 (Uniprot-TrEMBL)
p-IGFBP3 ProteinP17936 (Uniprot-TrEMBL)
p-IGFBP4 ProteinP22692 (Uniprot-TrEMBL)
p-IGFBP5 ProteinP24593 (Uniprot-TrEMBL)
p-IGFBP7 ProteinQ16270 (Uniprot-TrEMBL)
p-IL6 ProteinP05231 (Uniprot-TrEMBL)
p-ITIH2 ProteinP19823 (Uniprot-TrEMBL)
p-KNG1 ProteinP01042 (Uniprot-TrEMBL)
p-KTN1 ProteinQ86UP2 (Uniprot-TrEMBL)
p-LAMB1 ProteinP07942 (Uniprot-TrEMBL)
p-LAMB2 ProteinP55268 (Uniprot-TrEMBL)
p-LAMC1 ProteinP11047 (Uniprot-TrEMBL)
p-LGALS1 ProteinP09382 (Uniprot-TrEMBL)
p-LTBP1 ProteinQ14766 (Uniprot-TrEMBL)
p-MATN3 ProteinO15232 (Uniprot-TrEMBL)
p-MBTPS1 ProteinQ14703 (Uniprot-TrEMBL)
p-MELTF ProteinP08582 (Uniprot-TrEMBL)
p-MEN1 ProteinO00255 (Uniprot-TrEMBL)
p-MEPE ProteinQ9NQ76 (Uniprot-TrEMBL)
p-MFGE8 ProteinQ08431 (Uniprot-TrEMBL)
p-MGAT4A ProteinQ9UM21 (Uniprot-TrEMBL)
p-MIA3 ProteinQ5JRA6 (Uniprot-TrEMBL)
p-MSLN ProteinQ13421 (Uniprot-TrEMBL)
p-MXRA8 ProteinQ9BRK3 (Uniprot-TrEMBL)
p-NOTUM ProteinQ6P988 (Uniprot-TrEMBL)
p-NUCB1 ProteinQ02818 (Uniprot-TrEMBL)
p-P4HB ProteinP07237 (Uniprot-TrEMBL)
p-PCSK9 ProteinQ8NBP7 (Uniprot-TrEMBL)
p-PDIA6 ProteinQ15084 (Uniprot-TrEMBL)
p-PENK ProteinP01210 (Uniprot-TrEMBL)
p-PNPLA2 ProteinQ96AD5 (Uniprot-TrEMBL)
p-PRKCSH ProteinP14314 (Uniprot-TrEMBL)
p-PROC ProteinP04070 (Uniprot-TrEMBL)
p-PRSS23 ProteinO95084 (Uniprot-TrEMBL)
p-QSOX1 ProteinO00391 (Uniprot-TrEMBL)
p-RCN1 ProteinQ15293 (Uniprot-TrEMBL)
p-SCG2 ProteinP13521 (Uniprot-TrEMBL)
p-SCG3 ProteinQ8WXD2 (Uniprot-TrEMBL)
p-SDC2 ProteinP34741 (Uniprot-TrEMBL)
p-SERPINA1 ProteinP01009 (Uniprot-TrEMBL)
p-SERPINA10 ProteinQ9UK55 (Uniprot-TrEMBL)
p-SERPINC1 ProteinP01008 (Uniprot-TrEMBL)
p-SERPIND1 ProteinP05546 (Uniprot-TrEMBL)
p-SHISA5 ProteinQ8N114 (Uniprot-TrEMBL)
p-SPARCL1 ProteinQ14515 (Uniprot-TrEMBL)
p-SPP1 ProteinP10451 (Uniprot-TrEMBL)
p-SPP2 ProteinQ13103 (Uniprot-TrEMBL)
p-STC2 ProteinO76061 (Uniprot-TrEMBL)
p-TF ProteinP02787 (Uniprot-TrEMBL)
p-TGOLN2 ProteinO43493 (Uniprot-TrEMBL)
p-TIMP1 ProteinP01033 (Uniprot-TrEMBL)
p-TMEM132A ProteinQ24JP5 (Uniprot-TrEMBL)
p-TNC ProteinP24821 (Uniprot-TrEMBL)
p-VCAN ProteinP13611 (Uniprot-TrEMBL)
p-VGF ProteinO15240 (Uniprot-TrEMBL)
p-VWA1 ProteinQ6PCB0 (Uniprot-TrEMBL)
p-WFS1 ProteinO76024 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-8952289 (Reactome)
ATPR-HSA-8952289 (Reactome)
FAM20C:FAM20AArrowR-HSA-8952289 (Reactome)
FAM20C:FAM20C substratesR-HSA-8952289 (Reactome)
FAM20C:FAM20C substratesmim-catalysisR-HSA-8952289 (Reactome)
FAM20C:Phosphorylated FAM20C substratesArrowR-HSA-8952289 (Reactome)
R-HSA-8952289 (Reactome) Extracellular serine/threonine protein kinase FAM20C is an extracellular kinase that can phosphorylate a broad range of secreted protein. FAM20C is bound and allosterically activated by the pseudokinase FAM20A (Tagliabracchi et al. 2012, 2015, Cui et al. 2015).
Loss of function mutations in Fam20C cause Raine Syndrome, an osteosclerotic bone dysplasia (Faundes et al. 2014).
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